Children's Center for Clinical Pharmacology Studies
儿童临床药理学研究中心
基本信息
- 批准号:7867294
- 负责人:
- 金额:$ 35.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-01-01 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAgeAllyAreaBioinformaticsBiological AvailabilityCandidate Disease GeneChildChildhoodCitiesClinical PharmacistsClinical PharmacologyClinical ResearchClinical TrialsClinical Trials DesignClinics and HospitalsCollaborationsDataDevelopmentDisciplineDiseaseDrug Delivery SystemsDrug ExposureDrug KineticsDrug LabelingDrug effect disorderEducational process of instructingEnvironmentEnzymesExtramural ActivitiesFundingGeneticGrowthHealth ProfessionalInfantInstitutionInvestigationKansasKnowledgeLabelLinkMedicalMetabolic BiotransformationMissouriMolecularNational Institute of Child Health and Human DevelopmentNursesPharmaceutical PreparationsPharmacodynamicsPharmacogeneticsPharmacogenomicsPharmacologyPhaseProcessProduct LabelingRegulationResearchResearch PersonnelResearch ProposalsResourcesSafetySiteSourceSpecialistSurrogate MarkersTraining and EducationTranslational ResearchValidationbasedesigndrug developmentdrug marketdrug metabolismevidence basemeetingsmetabolomicsneonatenew technologynovelnovel strategiesnovel therapeuticspediatric pharmacologypediatricianprogramsreceptorresponse
项目摘要
DESCRIPTION (provided by applicant):
This proposal is a sent in response to RFA #HD-01-003 to continue funding of a Pediatric Pharmacology Research Unit at Children's Mercy Hospitals and Clinics (CMH) in Kansas City, Missouri as one of the sites within the NICHD Network of PPRU's. The overall objectives of the Unit are: 1) to continue and expand collaborative participation of the CMH PPRU in the PPRU Network for the primary purpose of producing data that will support labeling of drugs for children through the creation of new information and knowledge; and 2) To conduct basic and translational research in developmental pharmacology that will advance our understanding of the impact of genetic- age- and disease-related differences in drug disposition and action (both beneficial and adverse). Specific Aims include: 1) The collaborative conduct of studies of new and currently marketed drugs with priority given to PPRU Network studies; 2) The identification, collation, analysis, and interpretation of data from pediatric clinical trials that are sufficient for expansion of pediatric labeling; 3) Use of molecular approaches to define the "link" between childhood development, disease expression, drug biotransformation and drug action; 4) Use of bioinformatics, pharmacogenomics, metabolomics to explore and define the basis of developmental regulation of important drug metabolizing enzymes and transporters; 5) The provision of a unique teaching environment in which pediatricians, medical sub-specialists, clinical pharmacists, nurses and allied health care professionals can gain expertise in clinical investigation and the discipline of pediatric clinical pharmacology. The capability of the investigators and applicant institution to accomplish these objectives and specific aims is demonstrated by: I) effective programmatic composition and administration; 2) expertise and resources within the applicant institution; 3) previous and current research accomplishments related to the PPRU Network; 4) projected programmatic expansion necessary to meet the anticipated increased demands for pediatric clinical trials over the next five years and also, to enhance the integration of translational science into the drug development process; and 5) presentation of two new research proposals which speak directly to the program objectives and are ideally suited for conduct as part of the PPRU Network.
描述(由申请人提供):
本提案是对RFA#HD-01-003的回应,目的是继续资助密苏里州堪萨斯城儿童慈悲医院和诊所(CMH)的儿科药理研究股,作为PPRU NICHD网络内的站点之一。该股的总体目标是:1)继续并扩大CMH PPRU在PPRU网络中的合作参与,主要目的是产生数据,通过创造新的信息和知识支持儿童药物标签;2)开展发展药理学的基础研究和转化研究,这将促进我们对药物处置和作用(包括有益和不利的)的遗传、年龄和疾病相关差异的影响的理解。具体目标包括:1)合作进行新药和当前上市药物的研究,优先考虑PPRU网络研究;2)识别、整理、分析和解释足以扩大儿科标签的儿科临床试验数据;3)使用分子方法定义儿童发育、疾病表现、药物生物转化和药物作用之间的“联系”;4)使用生物信息学、药物基因组学、代谢组学来探索和确定重要药物代谢酶和转运体的发育调节基础;5)提供独特的教学环境,让儿科医生、医学专科医生、临床药剂师、护士和专职医护人员在临床调查和儿科临床药理学学科方面获得专业知识。研究人员和申请机构实现这些目标和具体目标的能力体现在:i)有效的计划组成和管理;2)申请机构内的专业知识和资源;3)与PPRU网络有关的以往和目前的研究成就;4)预计的计划扩展,以满足未来五年对儿科临床试验的预期增加的需求,并加强将转化科学纳入药物开发过程;以及5)提出两项新的研究建议,这两项建议直接与计划目标有关,非常适合作为PPRU网络的一部分进行。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gregory Lee Kearns其他文献
Gregory Lee Kearns的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gregory Lee Kearns', 18)}}的其他基金
Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology
儿童慈善医院儿科药理学奖学金计划
- 批准号:
8457132 - 财政年份:2011
- 资助金额:
$ 35.97万 - 项目类别:
Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology
儿童慈善医院儿科药理学奖学金计划
- 批准号:
8252118 - 财政年份:2011
- 资助金额:
$ 35.97万 - 项目类别:
Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology
儿童慈善医院儿科药理学奖学金计划
- 批准号:
8658128 - 财政年份:2011
- 资助金额:
$ 35.97万 - 项目类别:
Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology
儿童慈善医院儿科药理学奖学金计划
- 批准号:
8121315 - 财政年份:2011
- 资助金额:
$ 35.97万 - 项目类别:
Children's Center for Clinical Pharmacology Studies
儿童临床药理学研究中心
- 批准号:
7169817 - 财政年份:1994
- 资助金额:
$ 35.97万 - 项目类别:
Children's Center for Clinical Pharmacology Studies
儿童临床药理学研究中心
- 批准号:
7006117 - 财政年份:1994
- 资助金额:
$ 35.97万 - 项目类别:
Children's Center for Clinical Pharmacology Studies
儿童临床药理学研究中心
- 批准号:
6729627 - 财政年份:1994
- 资助金额:
$ 35.97万 - 项目类别:
Children's Center for Clinical Pharmacology Studies
儿童临床药理学研究中心
- 批准号:
7359665 - 财政年份:1994
- 资助金额:
$ 35.97万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 35.97万 - 项目类别:
Research Grant