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Alteration of bronchial epithelium host defenses by marijuana and vaping preparations

Alteration of bronchial epithelium host defenses by marijuana and vaping preparations
大麻和电子烟制剂改变支气管上皮宿主防御
批准号:
10753830
负责人:
Estelle A Cormet-Boyaka
金额:
$19.69万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-09-15 至 2025-08-31
关键词:
AcuteAirApicalBacteriaBacterial InfectionsBehaviorCNR1 geneCNR2 geneCannabidiolCannabinoidsCell ProliferationCellsChronicChronic BronchitisCigaretteCiliaCoughingCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDataDevicesElectronic cigaretteEnvironmental PollutantsEpithelial CellsExcisionExposure toFrequenciesGene ExpressionGenesGoalsGoblet CellsHealthHomeostasisHost DefenseHumanHydration statusHyperplasiaImpairmentIn VitroInfectionInfection preventionInhalationIon ChannelLegalLiquid substanceLong-Term EffectsLungLung diseasesMarijuanaMarijuana SmokingMeasuresMedical MarijuanaMetaplasiaModelingMolecularMolecular TargetMucociliary ClearanceMucous body substanceNational Institute of Drug AbuseNatureObstructive Lung DiseasesOutcomePathway AnalysisPathway interactionsPatientsPeptidesPersonsPredispositionPreparationPrimary Ciliary DyskinesiasProductionProteinsProteomicsPsychotropic DrugsRNARecoveryRecreationResearchResearch Project GrantsRheologyRiskRoleSecretory CellSmokerSmokingSputumStaphylococcus aureus infectionSubstance Use DisorderSystemTHC exposureTeenagersTestingTetrahydrocannabinolTobacco smoking behaviorUS StateUnited StatesUnited States National Institutes of HealthVirusVirus Diseasesairway epitheliumantimicrobialantimicrobial drugbronchial epitheliumcannabinoid receptorcigarette smokingdifferential expressionepigenomicsexposure to cigarette smokefunctional genomicsin vivolung developmentmarijuana smokemarijuana usemarijuana vapingmethicillin resistant Staphylococcus aureusparticlepathogenpathogenic microberesponsetranscriptome sequencingtranscriptomicstreatment effectvapingvaping THC

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英文摘要
PROJECT SUMMARY Marijuana smoking and vaping is on the rise in the United States with the increased legalization of recreational and medical marijuana. The main psychoactive component present in marijuana, and added to vaping preparations, is delta-9-tetrahydrocannabinol (THC). Even though the effect of marijuana smoking on obstructive lung disease can vary between studies, it is recognized that marijuana smoking is associated with increased cough, sputum production, and chronic bronchitis often associated with infections, but the mechanism remains to be determined. Our preliminary data show that chronic exposure of THC alone to primary human bronchial epithelial cells grown at air-liquid interface alters several components of the mucociliary function (i.e. ion channels, cilia beating), resulting in increased susceptibility to infections. Environmental pollutants, such as cigarette smoking, can alter gene expression. Unfortunately, some of the changes can persist despite cessation. The goal of this study is to determine the effects of THC-containing preparations (marijuana and vaping) on bronchial epithelium host defenses. This proposal is submitted in response to NOT-DA-20-031 “Transcriptomic, epigenomic, regulatory RNA or functional genomic research in substance use disorders”. Here, we propose to (1) determine whether chronic exposures to THC through marijuana smoke or vaping differentially alter the bronchial epithelium functions involved in host defense against microbial pathogens; and (2) identify the nature of transcriptomic changes which persist in bronchial epithelium after cessation from exposures to marijuana smoke or vaping. This comprehensive study will reveal the effects of THC in marijuana smoke and vaping preparations on airway homeostasis and identify new molecular targets to prevent infections and development of lung diseases.
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  • 项目类别:
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  • 负责人:
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