Regulation of axonal proteins synthesis

轴突蛋白质合成的调节

基本信息

  • 批准号:
    7771509
  • 负责人:
  • 金额:
    $ 2.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-08-15 至 2011-02-28
  • 项目状态:
    已结题

项目摘要

It has become accepted that the axonal compartment can autonomously synthesize proteins. This local translation provides the axon with a renewable source of proteins to respond to extracellular stimuli. Studies from the Pi's group have shown that axonal protein synthesis is triggered by neural injury and that particularly robust protein synthesis occurs in regenerating axons. This localized protein synthesis represents a mechanism that can likely be harnessed to facilitate the regeneration of axons in the adult nervous system. Despite the obvious functional significance and newly increased interests in axonal protein synthesis, we little understanding of how this process is regulated. Our preliminary studies indicate that adult axons have the potential to synthesize a complex population of more than 200 different proteins; there is clearly some specificity to choose which proteins are generated when and where. The objective of this proposal is to determine how this axonal protein synthesis is regulated. We hypothesize that axonal stimulation alters localized protein synthesis through both directing the transport of particular mRNAs into the axonal compartment and locally controlling the activity of the axonaltranslational machinery. In Aim 1, we will determine how axonal guidance cues and growth promoting stimuli modify specificity of axonal protein synthesis. The contributions of axonal transport vs. localized synthesis will be determined for each axonally synthesized protein identified. The physiological consequences of localized synthesis of these proteins in axonal growth will be addressed. In Aim 2 we will ask how the axon controls synthesis of organelle and membrane proteins and the functional relevance of these pathways to nerve regeneration. Nerve regeneration is abysmally slow and rarely successful. It has recently been recognized that injured nerve processes are capable of generating their own proteins. Our studies indicate that this may be used to enhance recovery after injury of the nervous system. The objective of this grant application is to determine how local protein synthesis in nerve processes is regulated by extracellular stimuli.
轴突室可以自主合成蛋白质的观点已经被人们所接受。这个地方

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Regulation of mRNA transport and translation in axons.
轴突中 mRNA 运输和翻译的调节。
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JEFFERY L TWISS其他文献

JEFFERY L TWISS的其他文献

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{{ truncateString('JEFFERY L TWISS', 18)}}的其他基金

Role of Stress Granule Protein Aggregation in Axon Regeneration
应激颗粒蛋白聚集在轴突再生中的作用
  • 批准号:
    10265401
  • 财政年份:
    2020
  • 资助金额:
    $ 2.38万
  • 项目类别:
Role of Stress Granule Protein Aggregation in Axon Regeneration
应激颗粒蛋白聚集在轴突再生中的作用
  • 批准号:
    10406395
  • 财政年份:
    2020
  • 资助金额:
    $ 2.38万
  • 项目类别:
Role of Stress Granule Protein Aggregation in Axon Regeneration
应激颗粒蛋白聚集在轴突再生中的作用
  • 批准号:
    10447127
  • 财政年份:
    2020
  • 资助金额:
    $ 2.38万
  • 项目类别:
Role of Stress Granule Protein Aggregation in Axon Regeneration
应激颗粒蛋白聚集在轴突再生中的作用
  • 批准号:
    10647839
  • 财政年份:
    2020
  • 资助金额:
    $ 2.38万
  • 项目类别:
Role of Stress Granule Protein Aggregation in Axon Regeneration
应激颗粒蛋白聚集在轴突再生中的作用
  • 批准号:
    10030563
  • 财政年份:
    2020
  • 资助金额:
    $ 2.38万
  • 项目类别:
Destabilization of axonal mRNAs by KHSRP complexes during axon regeneration
轴突再生过程中 KHSRP 复合物导致轴突 mRNA 不稳定
  • 批准号:
    10666545
  • 财政年份:
    2015
  • 资助金额:
    $ 2.38万
  • 项目类别:
Destabilization of axonal mRNAs by KHSRP complexes during axon regeneration
轴突再生过程中 KHSRP 复合物导致轴突 mRNA 不稳定
  • 批准号:
    10430242
  • 财政年份:
    2015
  • 资助金额:
    $ 2.38万
  • 项目类别:
Destabilization of axonal mRNAs by KHSRP complexes during axon regeneration
轴突再生过程中 KHSRP 复合物导致轴突 mRNA 不稳定
  • 批准号:
    10306001
  • 财政年份:
    2015
  • 资助金额:
    $ 2.38万
  • 项目类别:
Systems dynamics of intracellular communication (Spatial 2011)
细胞内通讯的系统动力学(Spatial 2011)
  • 批准号:
    8129400
  • 财政年份:
    2011
  • 资助金额:
    $ 2.38万
  • 项目类别:
REGULATION OF AXONAL PROTEIN SYNTHESIS
轴突蛋白合成的调节
  • 批准号:
    8362758
  • 财政年份:
    2011
  • 资助金额:
    $ 2.38万
  • 项目类别:

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