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De-coding Cis-regulatory information on a Genome-Wide Level with Single Neuron Re

使用单神经元 Re 在全基因组水平上解码顺式调控信息

基本信息

批准号：
7762060
负责人：
Oliver Hobert
金额：
$ 2.99万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7762060
关键词：
Affect Anatomy Animals Applications Grants Architecture Axon Binding Biogenic Amine Receptors Biological Assay Caenorhabditis elegans Cells Code Collection Cues Defect Development Dissection Elements Ensure F Box Domain Family Fibroblast Growth Factor Receptors Fingers Funding Gene Expression Genes Genetic Genetic Screening Genome Genomics Grant Green Fluorescent Proteins Handedness Hodgkin Disease Homeobox Genes Homeodomain Proteins Immunoglobulin Domain In Vitro Individual Integral Membrane Protein Interneurons Left Link Logic Maintenance MicroRNAs Molecular Motor Motor Neurons Nature Nematoda Nerve Nervous system structure Neurites Neuronal Differentiation Neurons Nuclear Phylogenetic Analysis Positioning Attribute Postdoctoral Fellow Process Progress Reports Proteins Publications RNA-Binding Proteins Regulatory Element Regulatory Pathway Reporter Reporter Genes Research Role Science Signal Transduction Software Tools Synaptic Transmission System Testing Trans-Activators Transgenic Animals United States National Institutes of Health Work base cell type gene function genome-wide insight interest member mutant neuromuscular novel postsynaptic programs promoter protein expression receptor receptor expression transcription factor ubiquitin ligase

项目摘要

DESCRIPTION (provided by applicant): Nervous systems are characterized by an astounding degree of cellular diversity, yet our insights into the mechanisms of creating this diversity are limited. The molecular correlate to neuronal diversity are neuron-type specific gene expression programs. Sets of co-expressed genes that characterize an individual cell type are commonly referred to as gene batteries which are defined by their linkage to conserved, common c/s-regulatory elements. The nature of gene batteries for individual neuronal subtypes as well as their linked cis-regulatory elements are poorly described on a genome-wide level. We propose here to systematically decode cis-regulatory information on a genome-wide level and to determine the identity of a single neuron-specific gene expression program.

描述（由申请人提供）：神经系统的特征在于细胞多样性的惊人程度，但我们对创造这种多样性的机制的见解是有限的。与神经元多样性相关的分子是神经元类型特异性基因表达程序。表征单个细胞类型的共表达基因组通常被称为基因电池，其通过其与保守的共同顺式调控元件的连接来定义。单个神经元亚型的基因电池的性质以及它们的顺式调控元件在全基因组水平上的描述很少。我们建议在这里系统地解码顺式调控信息的全基因组水平，并确定一个单一的神经元特异性基因表达程序的身份。