CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持服务

• 批准号: 7844067
• 负责人: STEVE GRAVES
• 金额: $ 428.1万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844067
• 关键词: CHEMISTRY; SUPPORT; SERVICES; ENVIRONMENTAL; TOXICOLOGY

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. During FY09, more than 200 tasks are in progress or were completed in support of NTP and DIR research and testing protocols. The Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) requested to procure, coded and ship compounds for laboratory testing. A collection Alkylanilines were procured and purity determined in support of in vitro studies. Aminopyridines to be used in a 90-day gavage study were analyzed for purity. Method development for rat and mouse serum tissues has been completed. Bisphenol A was procured for a series of studies to be conducted at NCTR and given to graduate students through the intramural program at NIEHS. Individual lots of Dong Quai are being procured in order to be used for 90-gavage study. Vanadium compounds have been procured for potential NTP studies. Preliminary work on the solubility, stability ad speciation of these compounds in DI water has been completed. In support of a reproductive study being performed at RTI, Butyl paraben was procured, analyzed for purity with a follow up formulation analysis. Also, in preparation of an upcoming reproductive study, additional lots of 4MI have been procured and analyzed for purity. Definitive toxicokinetic IV and gavage studies in Harlan Sprague-Dawley male and female rats, lab work have been completed for the Toxicokinetics compounds for the Perfluronated Compounds. This was in support of a collection of general toxicology studies. The majority of the preliminary toxicokinetic studies have been completed.

该合同的目的是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，试验种属以规定的剂量浓度暴露于规定的化学品。该合同通过提供所研究化学品的特征、所施用剂量水平的确认和内部剂量确定，有助于毒性研究提供癌症风险增加沿着其他毒理学结果的证据。这些信息对于评价毒性试验和得出关于研究化学品在试验种属中的潜在毒性的合理科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据该合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。在2009财政年度，有200多项任务正在进行或已经完成，以支持NTP和ESTA的研究和测试协议。替代毒理学方法评估机构间中心（NICEATM）要求采购、编码和运输化合物进行实验室测试。 收集烷基苯胺，并测定纯度以支持体外研究。 分析了90天灌胃研究中使用的氨基吡啶的纯度。已完成大鼠和小鼠血清组织的方法开发。 双酚A被采购用于在NCTR进行的一系列研究，并通过NIEHS的校内项目提供给研究生。 正在采购Dong Quai的单个批次，以用于90-灌胃研究。 已采购钒化合物用于潜在的NTP研究。 这些化合物在去离子水中的溶解度、稳定性和形态的初步研究已经完成。 为了支持在RTI进行的生殖研究，采购了尼泊金丁酯，并进行了纯度分析和后续制剂分析。此外，在准备即将进行的生殖研究时，还采购了额外批次的4 MI，并进行了纯度分析。在哈兰Sprague-Dawley雄性和雌性大鼠中进行的连续毒代动力学IV和灌胃研究，已完成全氟化合物毒代动力学化合物的实验室工作。 这是为了支持一系列一般毒理学研究。 已完成大部分初步毒代动力学研究。