CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

本合同的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。在毒性研究中，必须进行适当的化学分析，以确保试验物种暴露在指定剂量浓度的指定化学品中。这份合同有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果，方法是提供所研究的化学物质的特性、所用剂量水平的确认以及内部剂量测定。这些信息对于评估毒性测试和制定关于研究化学品在测试物种中的潜在毒性的合理、科学的结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据这份合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。在2009财年，200多项任务正在进行或已完成，以支持NTP和DIR研究和测试协议。替代毒理学方法评估机构间中心(NICEATM)要求采购、编码和运输化合物以供实验室测试。采集了烷基苯胺，并测定了纯度，以支持体外研究。对用于90天灌胃研究的氨基吡啶进行了纯度分析。大鼠和小鼠血清组织的制备方法已经完成。双酚A被用于在NCTR进行的一系列研究，并通过NIEHS的内部计划提供给研究生。 个体批量的东快正在被采购，以用于90天的饲喂研究。钒化合物已被用于潜在的NTP研究。关于这些化合物在去离子水中的溶解度、稳定性和形态的初步工作已经完成。为了支持RTI正在进行的生殖研究，采购了对羟基苯甲酸丁酯，分析了纯度，并进行了后续配方分析。此外，在为即将到来的生殖研究做准备的过程中，还获得了更多的4毫升，并对其进行了纯度分析。在Harlan Spraogue-Dawley雄性和雌性大鼠身上进行了明确的毒代动力学IV和灌胃研究，四氟脲类化合物的毒代动力学化合物的实验室工作已经完成。这是为了支持一般毒理学研究的集合。大部分的初步毒代动力学研究已经完成。

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. During FY09, more than 200 tasks are in progress or were completed in support of NTP and DIR research and testing protocols. The Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) requested to procure, coded and ship compounds for laboratory testing. A collection Alkylanilines were procured and purity determined in support of in vitro studies. Aminopyridines to be used in a 90-day gavage study were analyzed for purity. Method development for rat and mouse serum tissues has been completed. Bisphenol A was procured for a series of studies to be conducted at NCTR and given to graduate students through the intramural program at NIEHS. Individual lots of Dong Quai are being procured in order to be used for 90-gavage study. Vanadium compounds have been procured for potential NTP studies. Preliminary work on the solubility, stability ad speciation of these compounds in DI water has been completed. In support of a reproductive study being performed at RTI, Butyl paraben was procured, analyzed for purity with a follow up formulation analysis. Also, in preparation of an upcoming reproductive study, additional lots of 4MI have been procured and analyzed for purity. Definitive toxicokinetic IV and gavage studies in Harlan Sprague-Dawley male and female rats, lab work have been completed for the Toxicokinetics compounds for the Perfluronated Compounds. This was in support of a collection of general toxicology studies. The majority of the preliminary toxicokinetic studies have been completed.