课题基金 / 基金详情

项目摘要

项目成果

STEVE GRAVES的其他基金

相似基金

相关文献

中文摘要
翻译
国家毒理学规划的另一项倡议是研究纳米级材料富勒烯和纳米级二氧化钛。富勒烯在药物输送等许多用途上都很有趣,二氧化钛用于防晒霜和增白剂。这些化合物的特性特别注意颗粒大小和表面特性。为了支持即将到来的90天灌胃研究,C60富勒烯的纯度分析正在进行中。用于分析小鼠血浆、肝脏、肺、肾和肠道组织的方法正在开发中。与塑料管相比,铁氟龙提取没有显著差异。不同批次的血液来源的比较在初次制备后分析时没有差异,但是在聚四氟乙烯和塑料中稳定14天后,数据表明不同批次的血液之间存在差异,但在实际储存容器中没有差异。由于传统方法的失败,对样品进行了结合磨头机的研磨程序,以获得适当的颗粒样品尺寸。
英文摘要
Another NTP initiative are the studies of nanoscale materials, fullerenes, which are of interest for many uses including drug delivery, and nanoscale titanium dioxide, which is used in sunscreen and whitening agents. These compounds characterized with specific attention paid to particle size and surface characteristics. In support of an upcoming 90-day gavage study, purity analysis is in progress of the C60 fullerene. Method development for the analysis of mouse plasma, liver, lung, kidney, and gut tissues are in progress. There was no significant difference between the teflong extraction compared to plastic tubes. Comparison of different lots of blood sources showed no difference when analyzed after initial preparation however after 14 days of stability in both teflon and plastic the data indicates that there is variability between the different lots of blood but not in the actual storage containers. Because traditional methods failed, grinding procedure incorporating a bead mill was performed on samples to obtain the appropriate particle sample size.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
  • 批准号:
    7844067
  • 项目类别:
  • 资助金额:
    $428.1万
  • 财政年份:
    2005
  • 负责人:
    STEVE GRAVES
  • 依托单位:
CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
  • 批准号:
    7542975
  • 项目类别:
  • 资助金额:
    $332.5万
  • 财政年份:
    2005
  • 负责人:
    STEVE GRAVES
  • 依托单位:
    --
海外基金