Chemsitry Support Services to ETP for Nanotechnology

纳米技术 ETP 化学支持服务

• 批准号: 8089736
• 负责人: STEVE GRAVES
• 金额: $ 8.8万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089736
• 关键词: Adverse effects; Animals; Attention; Biological; Characteristics; Chemicals; Chemistry; Dose; Drug Delivery Systems; Drug Formulations; Environmental Exposure; Exposure to; Fullerenes; Goals; Hazard Identification; Human Resources; Kidney; Liquid substance; Liver; Lung; Materials Testing; Methods; Mus; Nanotechnology; National Toxicology Program; Nature; Particle Size; Pharmacologic Substance; Plasma; Preparation; Process; Research; Services; Sunscreening Agents; Support Contracts; Surface; Testing; Tissues; Toxic effect; Toxicity Tests; Toxicokinetics; Toxicology; Training; X ray diffraction analysis; anatase titanium dioxide; design; dietary supplements; disorder prevention; experience; fullerene C60; in vivo; instrumentation; interest; method development; nanoscale; programs; rutile; titanium dioxide

Another NTP initiative are the studies of nanoscale materials, fullerenes, which are of interest for many uses including drug delivery, and nanoscale titanium dioxide, which is used in sunscreen and whitening agents. These compounds characterized with specific attention paid to particle size and surface characteristics. In support of an upcoming 90-day gavage study, purity analysis is in progress of the C60 fullerene. Method development for the analysis of mouse plasma, liver, lung, kidney, and gut tissues are in progress. There was no significant difference between the teflong extraction compared to plastic tubes. Comparison of different lots of blood sources showed no difference when analyzed after initial preparation however after 14 days of stability in both teflon and plastic the data indicates that there is variability between the different lots of blood but not in the actual storage containers. Because traditional methods failed, grinding procedure incorporating a bead mill was performed on samples to obtain the appropriate particle sample size.

NTP的另一项举措是研究纳米级材料、富勒烯，这对包括药物输送在内的许多用途都有意义，以及纳米级二氧化钛，用于防晒和增白剂。这些化合物的特征在于特别注意颗粒尺寸和表面特性。为了支持即将进行的90天灌胃研究，正在进行C60富勒烯的纯度分析。用于分析小鼠血浆、肝脏、肺、肾脏和肠道组织的方法开发正在进行中。与塑料管相比，特氟隆浸提液之间无显著差异。初始制备后分析时，不同批次血液来源的比较显示无差异，但在聚四氟乙烯和塑料中稳定性14天后，数据表明不同批次血液之间存在变异性，但实际储存容器中不存在变异性。由于传统的方法失败了，对样品进行结合珠磨机的研磨程序以获得适当的颗粒样品尺寸。