CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持服务

• 批准号: 8089735
• 负责人: STEVE GRAVES
• 金额: $ 46.2万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089735
• 关键词: Adverse effects; Aminopyridines; Angelica sinensis preparation; Animals; Biological; Chemicals; Chemistry; Code; Collection; Contracts; Development; Dose; Drug Formulations; Ensure; Environmental Exposure; Evaluation; Exposure to; Female; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; Human Resources; In Vitro; Individual; Intramural Research Program; Laboratories; Liquid substance; Materials Testing; Methods; Mus; National Institute of Environmental Health Sciences; National Toxicology Program; Nature; Outcome; Parabens; Pharmacologic Substance; Preparation; Protocols documentation; Rattus; Research; Risk Assessment; Risk Factors; Series; Serum; Services; Shipping; Ships; Solubility; Specific qualifier value; Support Contracts; Testing; Tissues; Toxic effect; Toxicity Tests; Toxicokinetics; Toxicology; Training; Vanadium Compounds; Water; Work; bisphenol A; dietary supplements; disorder prevention; environmental toxicology; experience; follow-up; graduate student; in vivo; instrumentation; male; method development; programs; public health research; reproductive; sound

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify substances that are hazardous to human health. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. During FY10, more than 200 tasks are in progress or were completed in support of NTP and DIR research and testing protocols. The Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) requested support for a study requiring procurement, as well as coding and shipping of compounds for laboratory testing. Purity analysis for a planned aminopyridines subchronic gavage study is complete. Method development for these compounds in rat and mouse tissues has been completed. Individual lots of Dong Quai are being characterized that will be used in planned subchronic study. Analyses for four vanadium compounds have begun in anticipation of studies currently in design. Preliminary work on the solubility, purity and dose formulation have begun. In support of a reproductive study being performed at RTI, Butyl paraben was procured, analyzed for purity with a follow up formulation study analysis. Dose formulation being analyzed. Also, in preparation of an upcoming reproductive study, additional lots of 4MI have been procured and analyzed for purity. Definitive toxicokinetic IV and gavage studies for several perfluorinated compounds in Harlan Sprague-Dawley male and female rats have been completed and a 28-day gavage study has begun. A series of brominated compounds have been procured in preparation a series of hepatic gene expression and immunology studies. Gulf Oil samples and dispersants have been shipped to Battelle for potential analysis.

该合同的目的是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的物质。该合同通过提供所研究化学品的特征、所施用剂量水平的确认和内部剂量确定，有助于毒性研究提供癌症风险增加沿着其他毒理学结果的证据。这些信息对于评价毒性试验和得出关于研究化学品在试验种属中的潜在毒性的合理科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据该合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。在2010财年，有200多项任务正在进行或已经完成，以支持NTP和ESTA的研究和测试协议。替代毒理学方法评价机构间中心（NICEATM）要求支持一项研究，该研究需要采购以及编码和运输化合物用于实验室测试。计划的氨基吡啶亚慢性灌胃研究的纯度分析已完成。已经完成了这些化合物在大鼠和小鼠组织中的方法开发。正在表征将用于计划的亚慢性研究的Dong Quai单个批次。四种钒化合物的分析已经开始，预计目前正在设计的研究。关于溶解度、纯度和剂量配制的初步工作已经开始。为了支持在RTI进行的生殖研究，采购了尼泊金丁酯，并进行了纯度分析和后续制剂研究分析。正在分析的给药制剂。此外，在准备即将进行的生殖研究时，还采购了额外批次的4 MI，并进行了纯度分析。在哈兰Sprague-Dawley雄性和雌性大鼠中进行的几种全氟化合物的连续毒代动力学IV和灌胃研究已经完成，并开始了为期28天的灌胃研究。一系列溴代化合物已被用于制备一系列肝脏基因表达和免疫学研究。海湾石油样本和分散剂已被运往巴特尔进行潜在的分析。