CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

本合同的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于确定对人类健康有害的物质。这份合同有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果，方法是提供所研究的化学物质的特性、所用剂量水平的确认以及内部剂量测定。这些信息对于评估毒性测试和制定关于研究化学品在测试物种中的潜在毒性的合理、科学的结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据这份合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。在2010财年，200多项任务正在进行或已完成，以支持NTP和DIR研究和测试协议。替代毒理学方法评估机构间中心(NICEATM)请求支持一项研究，该研究需要采购，以及为实验室测试的化合物进行编码和运输。计划中的氨基吡啶亚慢性灌胃研究的纯度分析已经完成。这些化合物在大鼠和小鼠组织中的方法开发已经完成。东快的个体数量正在被表征，将被用于计划中的亚慢性研究。已经开始对四种钒化合物进行分析，预计目前正在进行研究。关于溶解度、纯度和剂量配方的初步工作已经开始。为了支持RTI正在进行的生殖研究，采购了帕拉苯丁酯，分析了纯度，并进行了后续配方研究分析。正在分析剂量配方。此外，在为即将到来的生殖研究做准备的过程中，还获得了更多的4毫升，并对其进行了纯度分析。几种全氟化合物在Harlan Spraogue-Dawley雄性和雌性大鼠体内的明确毒代动力学IV和灌胃研究已经完成，并开始了为期28天的灌胃研究。一系列的溴代化合物已被用于制备一系列的肝脏基因表达和免疫学研究。海湾石油样品和分散剂已运往巴特尔进行潜力分析。

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify substances that are hazardous to human health. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. During FY10, more than 200 tasks are in progress or were completed in support of NTP and DIR research and testing protocols. The Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) requested support for a study requiring procurement, as well as coding and shipping of compounds for laboratory testing. Purity analysis for a planned aminopyridines subchronic gavage study is complete. Method development for these compounds in rat and mouse tissues has been completed. Individual lots of Dong Quai are being characterized that will be used in planned subchronic study. Analyses for four vanadium compounds have begun in anticipation of studies currently in design. Preliminary work on the solubility, purity and dose formulation have begun. In support of a reproductive study being performed at RTI, Butyl paraben was procured, analyzed for purity with a follow up formulation study analysis. Dose formulation being analyzed. Also, in preparation of an upcoming reproductive study, additional lots of 4MI have been procured and analyzed for purity. Definitive toxicokinetic IV and gavage studies for several perfluorinated compounds in Harlan Sprague-Dawley male and female rats have been completed and a 28-day gavage study has begun. A series of brominated compounds have been procured in preparation a series of hepatic gene expression and immunology studies. Gulf Oil samples and dispersants have been shipped to Battelle for potential analysis.