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CHEMISTRY SUPPORT TO THE ENVIRONMENTAL TP

化学对环境的支持

基本信息

批准号：
6359427
负责人：
STEVE GRAVES
金额：
$ 348.59万
依托单位：
BATTELLE MEMORIAL INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-30 至 2006-01-31
项目状态：
已结题

项目摘要

This contract is for the recompetition of chemistry support services for the Environmental Toxicology Program (ETP) within the Division of Intramural Research (DIR) at the National Institute of Environmental Health Sciences (NIEHS). Chemistry support services will be needed for programs for which the ETP has responsibility: the Two-Year Bioassay; Short-Term Toxicology; Developmental Toxicology; Reproductive Toxicology; Immunology; and Neurotoxicology programs for the National Toxicology Program (NTP), the AIDS Therapeutics Program, and in-house research. The ETP conducts applied research with various chemicals and other potentially hazardous agents to improve test protocols, develop new tests, and improve interpretation of test results for the two-year bioassay program, short term toxicology program, and toxicity to the reproductive, immune and neurological systems. Insuring that the species under study are exposed to the prescribed chemicals at the specified dose concentrations, requires proper chemistry support including chemical characterization, dose formulation preparation, dose concentration verification, and internal dose determination. This contract will provide chemistry support services including bulk chemical procurement, bulk chemical handling, preliminary chemical studies, bulk chemical comprehensive analyses, limited bulk chemical analyses, bulk chemical inhalation analyses, bulk chemical reanalyses, dose formulation developmental studies, formulation preparation, formulation analyses, referee analyses, dose vehicle analyses, chemical storage, shipment, hazardous waste disposal, biological sample methods development, biological sample analyses, preliminary toxicokinetic studies, toxicokinetic studies, extended stability studies, and partion coefficient determination. Additional requirements include a quality management program, safety and health, animal care, waste disposal, computerized project management system, coordination with other NTP contractors, microfiching data, and providing continuity of services.

该合同是为国家环境健康科学研究所（NIEHS）校内研究部（INTRAMURURAL RESEARCH）内的环境毒理学计划（ETP）提供化学支持服务的再竞争。ETP负责的项目需要化学支持服务：两年生物测定;短期毒理学;发育毒理学;生殖毒理学;免疫学;国家毒理学计划（NTP）的神经毒理学计划，艾滋病治疗计划和内部研究。ETP对各种化学品和其他潜在危险物质进行应用研究，以改进测试方案，开发新的测试，并改善两年生物测定计划，短期毒理学计划以及生殖，免疫和神经系统毒性的测试结果的解释。确保研究种属暴露于规定剂量浓度的规定化学品，需要适当的化学支持，包括化学表征、给药制剂制备、剂量浓度验证和内部剂量测定。该合同将提供化学支持服务，包括散装化学品采购、散装化学品处理、初步化学研究、散装化学品综合分析、有限散装化学品分析、散装化学品吸入分析、散装化学品再分析、剂量制剂开发研究、制剂制备、制剂分析、裁判分析、剂量载体分析、化学品储存、装运、危险废物处置、生物样品方法开发、生物样品分析、初步毒代动力学研究、毒代动力学研究、扩展稳定性研究和分配系数测定。其他要求包括质量管理计划、安全和健康、动物护理、废物处理、计算机化项目管理系统、与其他NTP承包商的协调、缩微胶片数据以及提供连续性服务。