Chemsitry Support Services to ETP for Nanotechnology

国家毒理学规划的另一项倡议是研究纳米级材料富勒烯和纳米级二氧化钛。富勒烯在药物输送等许多用途上都很有趣，二氧化钛用于防晒霜和增白剂。这些化合物的特性特别注意颗粒大小和表面特性。为了支持即将到来的90天灌胃研究，C60富勒烯的纯度分析正在进行中。用于分析小鼠血浆、肝脏、肺、肾和肠道组织的方法正在开发中。一种提取方法也正在优化中。Eusolex T-2000、T-ECO和T-AVO的剂量分析已经完成。这包括制备用于FDA/NTCR研究的Eusolex和二氧化钛制剂。NCTR提供的各种批次二氧化钛的x射线衍射分析已经完成。这个分析的目的是确定二氧化钛的晶体状态。经鉴定，其中两块为金红石，另外三块为锐钛矿。

Another NTP initiative are the studies of nanoscale materials, fullerenes, which are of interest for many uses including drug delivery, and nanoscale titanium dioxide, which is used in sunscreen and whitening agents. These compounds characterized with specific attention paid to particle size and surface characteristics. In support of an upcoming 90-day gavage study, purity analysis is in progress of the C60 fullerene. Method development for the analysis of mouse plasma, liver, lung, kidney, and gut tissues are in progress. An extraction method is also in the process of being optimized. Analysis of the doses for the Eusolex T-2000, T-ECO, and T-AVO has been completed. This includes preparation of formulations of the Eusolex and Titanium Dioxide for FDA/NTCR study. X-ray Diffraction analysis of the various lots of Titanium dioxide provided by NCTR has been completed. This analysis was designed to determine the crystal state of the titanium dioxide. It was determined that two of lots were rutile and the other three were anatase.