Chemsitry Support Services to ETP for Nanotechnology

纳米技术 ETP 化学支持服务

• 批准号: 7944945
• 负责人: STEVE GRAVES
• 金额: $ 10万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944945
• 关键词: Chemsitry; Support; Services; ETP; Nanotechnology

Another NTP initiative are the studies of nanoscale materials, fullerenes, which are of interest for many uses including drug delivery, and nanoscale titanium dioxide, which is used in sunscreen and whitening agents. These compounds characterized with specific attention paid to particle size and surface characteristics. In support of an upcoming 90-day gavage study, purity analysis is in progress of the C60 fullerene. Method development for the analysis of mouse plasma, liver, lung, kidney, and gut tissues are in progress. An extraction method is also in the process of being optimized. Analysis of the doses for the Eusolex T-2000, T-ECO, and T-AVO has been completed. This includes preparation of formulations of the Eusolex and Titanium Dioxide for FDA/NTCR study. X-ray Diffraction analysis of the various lots of Titanium dioxide provided by NCTR has been completed. This analysis was designed to determine the crystal state of the titanium dioxide. It was determined that two of lots were rutile and the other three were anatase.

NTP 的另一项举措是研究纳米级材料、富勒烯（富勒烯）和纳米级二氧化钛（用于防晒霜和增白剂），富勒烯的用途广泛，包括药物输送。 这些化合物的特征特别关注颗粒尺寸和表面特性。为了支持即将进行的 90 天强饲研究，正在进行 C60 富勒烯的纯度分析。 小鼠血浆、肝脏、肺、肾脏和肠道组织分析方法的开发正在进行中。 提取方法也正在优化过程中。 Eusolex T-2000、T-ECO 和 T-AVO 的剂量分析已完成。 这包括为 FDA/NTCR 研究准备 Eusolex 和二氧化钛的配方。 NCTR 提供的各批次二氧化钛的 X 射线衍射分析已完成。 该分析旨在确定二氧化钛的晶态。 经确定，其中两批为金红石，另外三批为锐钛矿。