The role of autoimmune natural IgM in human myocardial infarction

描述(由申请人提供)：心肌梗死(MI)是当今社会死亡的主要原因。心肌损伤是细胞对缺血的内在反应和外源性急性炎症的一种表现。最近的临床前研究表明，预先存在的天然免疫球蛋白M在损伤诱导过程中发挥着内在和外在反应之间的关键中介作用。这项提议的目标是将这些新的基础科学发现扩展到临床层面。本研究为心肌梗死的临床治疗提供了新的依据。其具体目的如下：目的1.确定正常人和急性心肌梗死患者中是否存在针对缺血特异性自身抗原(非肌肉肌球蛋白重链II，NMHC-II)的天然IgM抗体。目的2.探讨这些自身免疫抗体水平与心肌损伤程度的关系。 公共卫生相关性 本研究将对缺血性心肌损伤的新机制提供重要的认识，并可能发现新的心肌梗死标志物。

DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a leading cause of mortality in today's society. Injury to myocardium is a manifestation of the intrinsic cellular response to ischemia and of an extrinsic acute inflammation. Recent pre-clinical studies have revealed that pre-existing natural IgM functions as the critical mediator between the intrinsic and extrinsic responses in injury induction. The goal of this proposal is to expand these novel basic science discoveries at the clinical level. Knowledge gained from this study will provide a new basis for clinical management of myocardial infarction. The specific aims are as follows: Aim 1. To determine whether natural IgM antibodies against an ischemia-specific self antigen (non-muscle myosin heavy chain II, NMHC-II) are present in normal individuals and patients with acute myocardial infarction. Aim 2. To investigate whether the levels of these autoimmune antibodies correlate with the degrees of myocardial injury. PUBLIC HEALTH RELEVANCE This study will provide important insight of a new mechanism in ischemic myocardial injury, and may identify new markers for myocardial infarction.