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Serosorting among Men at Risk for HIV

对有艾滋病毒风险的男性进行血清分类

基本信息

批准号：
7748004
负责人：
William McFarland
金额：
$ 36.08万
依托单位：
SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2010-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7748004
关键词：
AIDS prevention Adopted Affect African American Anal Sex Asians Behavior Behavioral Cities Cohort Studies Communities Complex Cross-Sectional Studies Data Disclosure Ejaculation Enrollment Epidemic Ethnic Origin Etiology Failure HIV HIV Infections HIV Seropositivity Harm Reduction Hispanics Human immunodeficiency virus test Incidence Individual Infection Internet Interview Knowledge Location Logistic Regressions Measures Methodology Methods Minority Modeling Motivation New York Oral Oral Sex Outcome Participant Perception Persons Phase Population Prevalence Prevention strategy Preventive Probability Probability Samples Race Rationalization Recruitment Activity Regression Analysis Reporting Research Personnel Respondent Risk Risk Behaviors Risk Reduction Role Sampling San Francisco Series Sexual Partners Sexually Transmitted Diseases Surveys Testing Time Viral Load result Withdrawal base cohort condoms contextual factors design follow-up hazard longitudinal analysis men men who have sex with men programs prospective sex skills success transmission process

项目摘要

DESCRIPTION (provided by applicant): We propose to obtain cross-sectional and longitudinal data on "HIV serosorting" among men who have sex with men (MSM) in San Francisco. We broadly define HIV serosorting as diverse strategies to reduce HIV acquisition or transmission by intentionally selecting sexual partners of the same serostatus or by modifying sexual practices depending on the partner's serostatus. The current phase of the HIV epidemic in San Francisco is complex with rising levels of overall unprotected anal sex (UAS) and sexually transmitted diseases (STD), yet stable HIV incidence. We hypothesize that HIV serosorting may explain these apparently contradictory findings; that is, increasing UAS with partners of the same HIV serostatus is leading to increases in STD incidence but not HIV incidence. While some evidence suggests serosorting may be increasing among MSM in San Francisco, many questions remain: How prevalent is serosorting as a deliberately adopted HIV prevention strategy in the MSM community? How do MSM identify partners of the same serostatus? What factors contribute to the success or failure of adhering to serosorting strategies? We need detailed and prospectively collected data in order to answer these questions and to assess the causal relationship between reported serosorting and actual risk for HIV. Accurate information is essential for dispelling misperceptions of serosorting if it is not causally associated with reducing serodiscordant UAS, or for increasing serosorting success if it is, or for framing serosorting in the context of risk reduction (but not elimination) if its in role in reducing risk is mixed. We propose to recruit a community-based cohort of HIV- negative and HIV-positive MSM using a probability-based time-location sampling method with longitudinal follow-up over the internet.

描述(由申请人提供)：我们建议获得旧金山男男性行为者(MSM)中“HIV血清检测”的横截面和纵向数据。我们广泛地将艾滋病毒血清检测定义为通过故意选择具有相同血清状态的性伴侣或通过根据伴侣的血清状态改变性行为来减少艾滋病毒感染或传播的不同策略。旧金山目前的艾滋病毒流行阶段很复杂，总体无保护肛交(UAS)和性传播疾病(STD)的水平不断上升，但艾滋病毒发病率保持稳定。我们假设HIV血清检测可以解释这些明显相互矛盾的发现；也就是说，与具有相同HIV血清状态的伴侣增加UA会导致STD发病率的增加，但不会导致HIV发病率的增加。虽然一些证据表明，在旧金山的MSM中，血清滴注可能正在增加，但许多问题仍然存在：在MSM社区中，血清滴定作为一种故意采用的艾滋病毒预防策略的流行程度如何？男男性接触者如何识别具有相同血清状态的伴侣？坚持血清滴定策略的成败由哪些因素决定？我们需要详细和前瞻性收集的数据，以回答这些问题，并评估报告的血清滴定与艾滋病毒实际风险之间的因果关系。准确的信息对于消除对血清滴定的误解是至关重要的，如果它与减少血清不一致的UA没有因果关系，或者如果它与减少血清不一致的UA有因果关系，那么对于增加血清滴定的成功率是至关重要的，或者如果它在降低风险方面的作用是混合的，那么对于在降低风险(但不是消除)的背景下框定血清滴定是至关重要的。我们建议在社区招募HIV阴性和HIV阳性的MSM，采用基于概率的时间-地点抽样方法，并通过互联网进行纵向跟踪。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Do rates of unprotected anal intercourse among HIV-positive MSM present a risk for hepatitis C transmission?

HIV 阳性 MSM 中无保护肛交的比例是否存在丙型肝炎传播的风险？

DOI：
10.1136/sti.2010.048223
发表时间：
2011
期刊：
Sexually transmitted infections
影响因子：
3.6
作者：
Stall,Ron;Wei,Chongyi;Raymond,HFisher;McFarland,Willi
通讯作者：
McFarland,Willi

Reaching black men who have sex with men: a comparison between respondent-driven sampling and time-location sampling.

DOI：
10.1136/sextrans-2012-050619
发表时间：
2012-12
期刊：
Sexually transmitted infections
影响因子：
3.6
作者：
Wei C;McFarland W;Colfax GN;Fuqua V;Raymond HF
通讯作者：
Raymond HF

Behavior, intention or chance? A longitudinal study of HIV seroadaptive behaviors, abstinence and condom use.

DOI：
10.1007/s10461-011-9936-8
发表时间：
2012-01
期刊：
AIDS AND BEHAVIOR
影响因子：
4.4
作者：
McFarland, Willi;Chen, Yea-Hung;Binh Nguyen;Grasso, Michael;Levine, Deb;Stall, Ron;Colfax, Grant;Robertson, Tyler;Truong, Hong-Ha M.;Raymond, H. Fisher
通讯作者：
Raymond, H. Fisher

HIV seroadaptation among individuals, within sexual dyads, and by sexual episodes, men who have sex with men, San Francisco, 2008.

DOI：
10.1080/09540121.2010.507748
发表时间：
2011-03
期刊：
AIDS care
影响因子：
1.7
作者：
McFarland W;Chen YH;Raymond HF;Nguyen B;Colfax G;Mehrtens J;Robertson T;Stall R;Levine D;Truong HM
通讯作者：
Truong HM

Hepatitis C prevalence among HIV-positive MSM in San Francisco: 2004 and 2008.

旧金山 HIV 阳性 MSM 中丙型肝炎患病率：2004 年和 2008 年。