Neurological Outcomes Among Pesticide Applicators

农药施用者的神经系统结果

• 批准号: 7900659
• 负责人: Fredric Gerr
• 金额: $ 20.75万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900659
• 关键词: Acetylcholinesterase; Agriculture; Carbamates; Chronic; Cohort Studies; Cytochrome P450; Enrollment; Epidemiologic Studies; Epidemiology; Exposure to; Funding; Genetic; Genetic Polymorphism; Glutathione S-Transferase; Health; Individual; Investigation; Iowa; Joints; Licensing; Long-Term Effects; Measures; Modeling; National Institute of Environmental Health Sciences; Nervous System Physiology; Neuraxis; Neurologic; Neurological outcome; Neuropsychological Tests; Neurotoxins; North Carolina; Organophosphates; Outcome; Participant; Performance; Peripheral; Pesticides; Recruitment Activity; Research Personnel; Sampling; Sampling Studies; Sum; Testing; Variant; aryldialkylphosphatase; experience; neurobehavioral; neurobehavioral test; neuropsychological; pesticide exposure; population based

Acetylcholinesterase inhibiting pesticides (i.e., organophosphate (OP) and carbamate pesticides) are widely used in the US and worldwide. Long-term neurological and neurobehavioral health effects of exposure to these pesticides are not well characterized. The investigators propose an epidemiological investigation of associations between long-term organophosphate and carbamate pesticide exposure and neurological and neurobehavioral health outcomes among approximately 700 pesticide applicators in Iowa and North Carolina (350 per state). Study participants will be recruited from among pesticide applicators currently enrolled in the Agricultural Health Study (AHS), a federally funded cohort study of licensed pesticide applicators from Iowa and North Carolina. Detailed information about individual exposure to a wide range of pesticides is available from the AHS. Applicators have been observed to experience wide variation in cumulative pesticide exposure making them suitable for investigation of health effects. Neurological and neurobehavioral health outcomes will be assessed with a battery of validated neurobehavioral tests that have been used successfully in previous investigations of neurotoxicant exposed individuals. The Primary Aim of the proposed investigation is to examine associations between cumulative lifetime exposure to the sum of all OP and carbamate pesticides and performance on selected measures of peripheral and central neurological function while controlling for effects of known covariates. A Secondary Aim of the proposal is to examine the effect of polymorphisms of paraoxonase, cytochromes P450, and glutathione-S-transferases (potential genetic modifiers of OP pesticide effect) on the association between exposure to OP pesticides and neurological and neuropsychological measures.

乙酰胆碱酯酶抑制农药（即有机磷 (OP) 和氨基甲酸酯农药）在美国和世界各地广泛使用。接触这些农药对神经和神经行为健康的长期影响尚不清楚。研究人员提议对爱荷华州和北卡罗来纳州约 700 名农药施用者（每个州 350 名）进行流行病学调查，调查长期接触有机磷和氨基甲酸酯农药与神经和神经行为健康结果之间的关系。研究参与者将从目前参加农业健康研究（AHS）的农药施用者中招募，这是一项联邦资助的针对爱荷华州和北卡罗来纳州获得许可的农药施用者的队列研究。有关个人接触多种农药的详细信息可从 AHS 获取。据观察，施用器的累积农药暴露量存在很大差异，这使得它们适合调查健康影响。神经学和神经行为健康结果将通过一系列经过验证的神经行为测试进行评估，这些测试已在之前对神经毒物暴露个体的调查中成功使用。拟议调查的主要目的是检查一生中累积接触所有有机磷农药和氨基甲酸酯农药的总和与选定的外周和中枢神经功能指标的表现之间的关联，同时控制已知协变量的影响。该提案的第二个目标是检查对氧磷酶、细胞色素 P450 和谷胱甘肽-S-转移酶（OP 农药效果的潜在遗传修饰剂）的多态性对 OP 农药暴露与神经学和神经心理学测量之间关联的影响。

项目成果

Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study.

• DOI: 10.1289/ehp.1103944
• 发表时间: 2012-04
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Starks SE;Hoppin JA;Kamel F;Lynch CF;Jones MP;Alavanja MC;Sandler DP;Gerr F
• 通讯作者: Gerr F

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study.

农业健康研究中农药施用者的高农药暴露事件和中枢神经系统功能。

• DOI: 10.1007/s00420-011-0694-8
• 发表时间: 2012
• 期刊: International archives of occupational and environmental health
• 影响因子: 3
• 作者: Starks,SarahE;Gerr,Fred;Kamel,Freya;Lynch,CharlesF;Alavanja,MichaelC;Sandler,DaleP;Hoppin,JaneA
• 通讯作者: Hoppin,JaneA