Childhood Poverty and Brain Development: The Role of Chronic Stress and Parenting

童年贫困和大脑发育：慢性压力和养育子女的作用

• 批准号: 7853072
• 负责人: Israel Liberzon
• 金额: $ 72.19万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7853072
• 关键词: Accounting; Achievement; Address; Adult; Affective; Age; Americas; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Area; Attention; Base of the Brain; Behavioral inhibition; Biological; Brain; Brain imaging; Brain region; Brain scan; Cardiovascular system; Child; Child Psychiatry; Childhood; Chronic; Chronic stress; Clinical Research; Cognitive; Crying; Data; Data Collection; Decision Making; Development; Emotional; Emotions; Environment; Face; Family; Functional Magnetic Resonance Imaging; Functional disorder; Funding Opportunities; Health; Hippocampus (Brain); Human Development; Hydrocortisone; Image; Income; Individual; Infant; Informal Social Control; Investigation; Laboratories; Life Cycle Stages; Link; Medial; Mediating; Mental Health; Mental disorders; Metabolic; Michigan; Monitor; Moods; National Institute of Mental Health; Neurobiology; Neurosecretory Systems; Parent-Child Relations; Parenting behavior; Parents; Participant; Patients; Perception; Performance; Persons; Phase; Physiological; Physiology; Positioning Attribute; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Poverty; Prefrontal Cortex; Process; Psychiatrist; Psychiatry; Psychologist; Psychoneuroendocrinology; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Risk; Role; Sampling; Scanning; Short-Term Memory; Social Interaction; Socioeconomic Status; Stimulus; Stress; Structure; Students; Techniques; Testing; Thick; Time; Trier Social Stress Test; Universities; Work; acute stress; allostatic load; biological adaptation to stress; brain behavior; cohort; depression; discounting; early childhood; emotional adjustment; experience; gray matter; innovation; neurodevelopment; neuroimaging; neurophysiology; post-doctoral training; primary outcome; professor; programs; psychosocial; research study; social; social neuroscience; stress related disorder; stressor; teacher; young adult

DESCRIPTION (provided by applicant): One fifth of America's children grow up in poverty. While there is good evidence that this is harmful to health, achievement, and socio-emotional adjustment, very little is known about the brain basis that mediates the detrimental effects of poverty. We address two related primary questions with this research project: (1) How does childhood poverty influence adult brain structure and function? (2). What underlying mechanisms might account for childhood poverty - brain relationships? We hypothesize chronic physiological stress dysregulation as well as harsh, unresponsive parenting during childhood will account for some of the expected linkages between childhood poverty - adult brain structure and function - particularly in the hippocampus, amygdala, and the anterior cingulate/medial prefrontal cortex. This work will piggyback onto a 14 year, ongoing longitudinal research program of low and middle-income individuals focused on childhood poverty, physiological stress, and socio-emotional development conducted by Evans, a developmental psychologist at Cornell. Half of this sample (now age 22) grew up below the poverty line and half middle income. The sample is well characterized over their life course in terms of SES and other demographic variables, as well as both physical and psychosocial risk exposures. Primary outcome variables for this longitudinal cohort include multiple methodological indicators of physiological stress (neuroendocrine, cardiovascular, and metabolic) along with parental, self, and teacher ratings of socioemotional development (internalization, externalization, self regulation. In depth data on parenting are also included. The neuroimaging work will be conducted in the Department of Psychiatry, University of Michigan by Liberzon, with expertise in the neuroimaging of stress in health and mental illness, and by Swain a child psychiatrist studying the brain basis of parenting. Brain scanning will be divided into 3 sessions: the first will acquire high resolution images for volumetric and cortical thickness analyses. In addition, a selective emotional attention task as well as an emotion appraisal/re- appraisal task will probe the functionality of amygdala-prefrontal circuits. With scan two, parenting stimuli consisting of baby cries and pictures will be used to activate circuits believed to relate to parenting behavior and social interactions. Furthermore, working memory, delayed discounting and behavioral inhibition tasks will test cortical inhibition, decision-making, in cortico-cortical and cortico-hippocampal circuitry. Finally, immediately prior to the third fMRI scan, a Trier Social Stress Test that reliably generates elevated cortisol levels in laboratory environment will be performed. The subsequent scans will directly assess brain function following acute stress induction, and allow comparison with the baseline brain function in these same subjects, including a repetition of the selective emotional attention task, the parenting task and the emotional face assessment task to re-examine amygdala, hippocampus and prefrontal cortex performance. These experiments utilize a uniquely well-characterized longitudinal sample of low- and middle-income individuals in combination with a comprehensive set of conceptually derived, innovative but also validated neuroimaging paradigms. The aim of this project is to examine the potential impacts of childhood poverty on the brain. We will examine areas of the brain well studied in relation to chronic stress and parent-child interactions.

描述(申请人提供)：五分之一的美国儿童在贫困中长大。虽然有很好的证据表明，这对健康、成就和社会情绪调整是有害的，但人们对调节贫困有害影响的大脑基础知之甚少。本研究解决了两个相关的主要问题：(1)儿童贫困对成人大脑结构和功能有何影响？儿童贫穷-大脑关系的潜在机制可能是什么？我们假设，儿童时期长期的生理压力失调，以及严厉、反应迟钝的父母教育，将解释儿童贫困与成人大脑结构和功能之间的一些预期联系--特别是在海马体、杏仁核和前扣带/内侧前额叶皮质。这项工作将借鉴康奈尔大学发展心理学家埃文斯对低收入和中等收入个人持续14年的纵向研究计划，该计划重点关注儿童贫困、生理压力和社会情感发展。这个样本中有一半人(现在22岁)生活在贫困线以下，另一半人是中等收入。根据SES和其他人口统计变量，以及身体和心理社会风险暴露，样本在他们的生命过程中具有良好的特征。这一纵向队列的主要结果变量包括生理应激的多种方法学指标(神经内分泌、心血管和代谢)以及父母、自我和教师对社会情绪发展(内化、外化、自我调节)的评级。关于育儿的深入数据也被包括在内。这项神经成像工作将在密歇根大学精神病学系进行，由Liberzon和Swain进行，前者擅长健康和精神疾病中压力的神经成像，后者是研究父母教育的大脑基础的儿童精神病学家。脑扫描将分为三个阶段：第一阶段将获得高分辨率图像，用于体积和皮质厚度分析。此外，选择性情绪注意任务以及情绪评估/重新评估任务将探索杏仁核-前额叶回路的功能。在第二次扫描中，由婴儿哭声和图片组成的育儿刺激将被用来激活据信与育儿行为和社交互动有关的回路。此外，工作记忆、延迟折扣和行为抑制任务将测试皮质-皮质和皮质-海马区的皮质抑制和决策。最后，就在第三次功能磁共振扫描之前，将进行Trier社会压力测试，该测试在实验室环境中可靠地产生升高的皮质醇水平。随后的扫描将直接评估急性应激诱导后的大脑功能，并允许与这些受试者的基线大脑功能进行比较，包括重复选择性情绪注意任务、育儿任务和情绪面孔评估任务，以重新检查杏仁核、海马体和前额叶皮质的表现。这些实验利用了一个独特的、具有良好特征的低收入和中等收入个人的纵向样本，并结合了一套全面的概念推导、创新但也得到验证的神经成像范例。这个项目的目的是研究儿童贫困对大脑的潜在影响。我们将研究大脑中与慢性压力和亲子互动相关的区域。