Cognition-Emotion-HPA Interaction: Translation Network

描述（由申请人提供）：情感过程和认知过程是处理信息的互补方式。情绪提供快速的“格式塔”评估，认知提供深思熟虑的、顺序的和分析性的控制。传统上，这些现象是孤立的，伴随情绪的躯体/神经内分泌状态被视为仅仅是大脑活动的外围标记。然而，神经内分泌活动实际上影响大脑，调节认知和情绪处理。我们认为，认知、情感和躯体（CES）过程实际上在相互关联的反馈回路中不断相互作用，而无效的CES相互作用可能导致功能失调的行为和精神病理。一个全面的帐户的相互作用，其贡献的精神疾病的发展，尚未出现。我们建议建立一个由认知/情感神经科学家、行为内分泌学家和临床研究人员组成的网络，开发实验工具，直接研究CES相互作用及其在精神病理学中的作用。

DESCRIPTION (provided by applicant): Emotional and cognitive processes are complementary ways to process information. Emotions provide rapid "gestalt" assessments, and cognition provides deliberative, sequential, and analytic control. Traditionally, these phenomena were examined in isolation and the somatic/neuroendocrine states that accompany emotions have been seen as mere peripheral markers of brain activity. However, neuroendocrine activity actually affects the brain, modulating cognitive and emotional processing. We propose that cognitive, emotional, and somatic (CES) processes in fact constantly interact in reciprocally interconnected feedback loops and that ineffective CES interaction can lead to dysfunctional behavior and psychopathology. A comprehensive account of CES interplay, and its contribution to the development of psychiatric disorders, has yet to emerge. We propose to create a network of cognitive/affective neuroscientists, behavioral endocrinologists and clinical researchers to develop experimental tools to directly examine CES interactions and their role in psychopathology. Six researchers (3 from Michigan and 3 from Columbia) will work together to (1) establish a translational network of clinical and basic behavioral scientists, (2) develop paradigms to study CES interactions, (3) collect pilot data to map the neurocircuitry of CES interaction, and (4) translate this approach to the study of psychopathology. To pursue these aims we propose specific steps towards network building (to create a multidisciplinary team and context for training translational scientists), paradigm development (to create novel experimental approaches), pilot experiments (to begin mapping the CES neurocircuitry), and translation to clinical relevance (by applying the models to psychiatric disorders, starting with PTSD). Three pilot experiments will utilize emotional (social stress), somatic (elevating cortisol) and cognitive manipulations, evaluating impacts in the domains of stimulus appraisal and decision making using neuroanatomical (fMRI), behavioral, and neuroendocrine outcome measures. These experiments will begin mapping CES neurocircuitry, probing interactions between and within prefrontal cortical regions (like cingulate and dorsomedial gyri, insula) and limbic structures (like amygdala, hippocampus, ventral caudate), and facilitate further paradigm development. The collaborative environment and multidisciplinary team will foster translational behavioral science mental health research, developing new paradigms and collecting preliminary data on CES interaction that shape behavior and contribute to psychopathology. It will provide a foundation for larger translational science projects and a context for training the translational scientists of the future.