BrainVision BrainAmp MR Plus

BrainVision BrainAmp MR Plus

• 批准号: 7595015
• 负责人: JIN FAN
• 金额: $ 12.07万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595015
• 关键词: Accounting; Advisory Committees; Attention deficit hyperactivity disorder; Autistic Disorder; Biological Factors; Bipolar Disorder; Brain; Data; Development; Electroencephalogram; Enrollment; Ensure; Equipment; Event; Event-Related Potentials; Functional Magnetic Resonance Imaging; Funding; Imaging Techniques; Knowledge; Laboratories; Measures; Mental disorders; Modeling; Public Health; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Role; Sampling; Structure; System; Techniques; Testing; Time; TimeLine; United States National Institutes of Health; cognitive function; instrumentation; medical schools; millimeter; millisecond; neuroimaging; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): Currently, the functional neuroimaging research conducted and supported by the Laboratory of Neuroimaging at the Mount Sinai School of Medicine utilizes fMRI as a primary measure. fMRI is the hallmark of spatial resolution amongst functional neuroimaging techniques, capable of resolving clusters of activation millimeters apart. However, its temporal resolution is on the order of several seconds. The temporal resolution of fMRI is determined not only by sampling interval but also by intrinsic biological factors. Therefore it is not possible to resolve events occurring within as much as one second of each other. An ideal complementary imaging technique for fMRI would have the ability to measure changes in activity with a temporal resolution on the order of milliseconds, and electrophysiological measures such as the electroencephalogram (EEG) or event related potentials (ERPs) have proven to fit this role perfectly. The current proposal aims to purchase an MRI-compatible EEG/ERP recording system in order to supplement fMRI data with high-temporal resolution electrophysiological data in order to expand the scope of hypotheses that are testable using the resources available through the Laboratory of Neuroimaging, a core functional neuroimaging resource of the Mount Sinai School of Medicine. Addition of this resource will facilitate development and testing of models of cognitive function that incorporate factors accounting for the temporal dynamics of networks subserving these functions. In addition to purchase of this system, we also propose the establishment of an unbiased local advisory committee who will oversee the administration of this resource to ensure that it continues to attract new users and that NIH funded projects are given rates of access to the resource commensurate with targeted subject enrollment and project timelines. Purchase of this equipment has direct relevance to public health because it will advance our knowledge of the neural underpinnings of various psychiatric disorders. Use of the new instrumentation in NIH funded projects investigating various aspects of autism, bipolar disorder, and attention deficit/hyperactivity disorder is discussed in detail with specific hypotheses that the instrumentation will permit testing of. With active expansion of the research infrastructure at Mount Sinai with a focus on clinically oriented research, it is expected that utilization of this core by NIH funded researchers will continue to grow over the next several years. PUBLIC HEALTH RELEVANCE: The aim of this proposal is to purchase equipment that will allow researchers to investigate the time course of activation of discrete structures in the brain with high temporal resolution, which is not possible using currently available resources. Purchase of this equipment will benefit several NIH-funded researchers conducting studies on various aspects of psychiatric disorders including autism, bipolar disorder, and attention deficit/hyperactivity disorder.

描述（由申请人提供）：目前，由西奈山医学院神经成像实验室进行和支持的功能性神经成像研究使用fMRI作为主要测量方法。 功能磁共振成像是功能神经成像技术中空间分辨率的标志，能够分辨相隔毫米的激活簇。 然而，其时间分辨率是几秒的量级。 fMRI的时间分辨率不仅取决于采样间隔，还取决于内在的生物学因素。 因此，不可能解决在一秒钟内发生的事件。 一个理想的功能磁共振成像的补充成像技术将有能力测量活动的变化与毫秒级的时间分辨率，和电生理措施，如脑电图（EEG）或事件相关电位（ERP）已被证明是完美的适合这一角色。 目前的提案旨在购买一个MRI兼容的EEG/ERP记录系统，以补充功能性MRI数据与高时间分辨率的电生理数据，以扩大假设的范围，这些假设可以使用西奈山医学院神经成像实验室的核心功能性神经成像资源进行测试。 这一资源的增加将促进认知功能模型的开发和测试，这些模型将考虑这些功能的网络的时间动态的因素。 除了购买该系统外，我们还建议建立一个公正的本地咨询委员会，该委员会将监督该资源的管理，以确保它继续吸引新用户，并确保NIH资助的项目获得与目标受试者招募和项目时间表相称的资源访问率。 购买这种设备与公共卫生直接相关，因为它将增进我们对各种精神疾病的神经基础的了解。 使用新的仪器在美国国立卫生研究院资助的项目调查自闭症，双相情感障碍，注意缺陷/多动障碍的各个方面进行了详细讨论，具体的假设，仪器将允许测试。 随着西奈山研究基础设施的积极扩展，重点是临床研究，预计NIH资助的研究人员对该核心的利用将在未来几年继续增长。 公共卫生相关性：该提案的目的是购买设备，使研究人员能够以高时间分辨率研究大脑中离散结构激活的时间过程，这是使用现有资源不可能实现的。 购买这台设备将使几位NIH资助的研究人员受益，这些研究人员正在对精神疾病的各个方面进行研究，包括自闭症、双相情感障碍和注意力缺陷/多动症。