ROLE OF ANXIETY IN NEUROBIOLOGIC ASPECTS OF DEPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管众所周知，压力、焦虑和抑郁之间存在联系，但焦虑和应激性生活事件对抑郁症神经生物学观察的影响尚不清楚。检查过了。压力和焦虑可能会引发一系列神经生物学事件，包括激活身体的主要应激防御系统，以及激活与获得和维持恐惧有关的大脑回路。在这项研究中，磁共振成像技术，包括形态测量MRI，磁共振波谱和功能磁共振成像，将被用来研究压力和焦虑在调节抑郁症的结构、化学和功能指标中的作用。基于对抑郁症的神经解剖学测量，我们将重点关注两个已知易受压力影响的大脑主要区域：海马体和前额叶皮质。抑郁的受试者将根据共病焦虑和早期和近期创伤/压力的病史进行彻底的表征。在西奈山医学中心招募的10名抑郁症受试者和随后匹配的健康对照组将接受形态测量MRI、MRS和fMRI测试。这个方案的主要优点在于对跨模式数据的分析，允许以综合的方式探索关于神经化学和功能之间的关系的问题，以及焦虑对抑郁症神经生物学结果的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the well known association of stress, anxiety and depression, the impact of anxiety and stressful life events on the neurobiological observations reported in depression have not been clearly. examined. Stress and anxiety may set in motion a series of neurobiological events including activation of the body's major stress-defense systems and activation of brain circuitry involved in the acquisition and maintenance of fear. In this study, MRI techniques, including morphometric MRI, MRS, and fMRI, will be used to examine the role of stress and anxiety in modulating structural, chemical and functional measures of depression. Based on neuroanatomical measures of depression we will focus on two main brain areas, both known to be vulnerable to stress: the hippocampus and the prefrontal cortex. Depressed subjects will be thoroughly characterized on measures of comorbid anxiety and history of early and recent trauma/stress. Ten depressed subjects and then matched healthy controls, recruited at the Mount Sinai Medical Center, will undergo morphometric MRI, MRS and fMRI testing. A major strength of this protocol lies in the analysis of cross-modal data, allowing the exploration of questions about the relationship between neurochemistry and function, and the influence of anxiety on neurobiological findings in depression, in an integrative manner