ROLE OF ANXIETY IN NEUROBIOLOGIC ASPECTS OF DEPRESSION

焦虑在抑郁的神经生物学方面的作用

• 批准号: 7718180
• 负责人: JIN FAN
• 金额: $ 0.17万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718180
• 关键词: Anxiety; Area; Brain; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Data; Depressed mood; Event; Fright; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Institution; Life; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maintenance; Measures; Medical center; Mental Depression; Motion; Neurobiology; Prefrontal Cortex; Protocols documentation; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Role; Series; Source; Stress; System; Techniques; Testing; Trauma; United States National Institutes of Health; base; neurochemistry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the well known association of stress, anxiety and depression, the impact of anxiety and stressful life events on the neurobiological observations reported in depression have not been clearly. examined. Stress and anxiety may set in motion a series of neurobiological events including activation of the body's major stress-defense systems and activation of brain circuitry involved in the acquisition and maintenance of fear. In this study, MRI techniques, including morphometric MRI, MRS, and fMRI, will be used to examine the role of stress and anxiety in modulating structural, chemical and functional measures of depression. Based on neuroanatomical measures of depression we will focus on two main brain areas, both known to be vulnerable to stress: the hippocampus and the prefrontal cortex. Depressed subjects will be thoroughly characterized on measures of comorbid anxiety and history of early and recent trauma/stress. Ten depressed subjects and then matched healthy controls, recruited at the Mount Sinai Medical Center, will undergo morphometric MRI, MRS and fMRI testing. A major strength of this protocol lies in the analysis of cross-modal data, allowing the exploration of questions about the relationship between neurochemistry and function, and the influence of anxiety on neurobiological findings in depression, in an integrative manner

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管压力、焦虑和抑郁之间的关系是众所周知的，但焦虑和压力性生活事件对抑郁症的神经生物学观察结果的影响尚不清楚。考察 压力和焦虑可能会引发一系列神经生物学事件，包括激活身体的主要压力防御系统和激活与获得和维持恐惧有关的大脑回路。 在这项研究中，MRI技术，包括形态测量MRI，MRS，和功能磁共振成像，将被用来检查压力和焦虑的作用，调制抑郁症的结构，化学和功能的措施。 基于抑郁症的神经解剖学测量，我们将重点关注两个主要的大脑区域，这两个区域都是已知的易受压力影响的区域：海马体和前额叶皮层。 抑郁受试者将通过共病焦虑和早期和近期创伤/压力史的测量进行全面表征。 在西奈山医学中心招募的10名抑郁症受试者和匹配的健康对照者将接受形态测量MRI、MRS和fMRI测试。 该协议的主要优势在于对跨模态数据的分析，允许以综合的方式探索有关神经化学与功能之间关系的问题，以及焦虑对抑郁症神经生物学发现的影响