3T MR scanner for imaging from mouse to human

用于从小鼠到人类成像的 3T MR 扫描仪

• 批准号: 7499444
• 负责人: Yi Wang
• 金额: $ 200万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499444
• 关键词: Applications Grants; Applied Research; Arts; Biomedical Engineering; Biomedical Research; Commit; Contracts; Core Facility; Development; Discipline; Engineering; Equilibrium; Equipment; Funding; Housing; Human; Image; Imaging Techniques; Institution; Magnetic Resonance Imaging; Medical Research; Mission; Mus; Neurosciences; Noise; Operative Surgical Procedures; Preparation; Research; Research Infrastructure; Resolution; Resources; Science; Signal Transduction; Site; Speed; Technology; United States National Institutes of Health; Universities; Veterinary Medicine; college; cost; design; human ecology; instrument; programs; public health relevance; research facility; success

DESCRIPTION (provided by applicant): The purpose of this proposal is to facilitate the purchase of a 3T MRI scanner for basic and applied research at Cornell University. This 3T scanner will be the first MRI research instrument at the Cornell Ithaca campus, providing capabilities for imaging from mouse to human with high signal-to-noise ratio, imaging speed, and spatial and spectral resolution. This research-dedicated scanner will remedy the critical lack of MRI access for biomedical and neuroscience NIH-funded projects on campus. Moreover, it will maintain, enhance and enable high quality biomedical research at Cornell University. The 3T MRI scanner will be a University-wide resource housed as an MRI Core Facility within the College of Human Ecology, Cornell Ithaca campus. Space and substantial infrastructure for operations for the 3T MRI scanner have been allocated. The total cost for purchasing, site preparation and installation of the 3T MRI scanner is approximately $2.8M. In addition to the requested $2M from this proposal, the University (Vice Provost for Research, College of Human Ecology, College of Veterinary Medicine, College of Engineering, College of Arts and Sciences, and Department of Biomedical Engineering) has committed the funds and resources to cover the remaining costs associated with this purchase, as well as the initial two-year operation. The mission of Cornell University's MRI Core Facility is to promote the development and synergistic application of non-invasive imaging techniques to a broad range of medical research disciplines. The organization, staffing, equipment procurement, and operational funding of the MRI Core are all designed to assure the success of this mission. Presently, there are 22 active NIH projects (17 R01s, 2 R21s, 1 R03, and 2 contracts) that make substantial use of magnetic resonance imaging. Additionally, 20 pending NIH grant proposals will be enhanced/enabled by this MRI Core Facility. This requested 3T MRI scanner will provide a balanced technology needed for imaging from mouse to human. Its incorporation into a campus-wide core research facility is essential for successfully conducting and expanding NIH-funded cutting-edge imaging research programs at our institution. PUBLIC HEALTH RELEVANCE:

描述（由申请人提供）：本提案的目的是促进康奈尔大学购买用于基础和应用研究的3 T MRI扫描仪。这台3 T扫描仪将成为康奈尔大学伊萨卡校区的第一台MRI研究仪器，提供从小鼠到人类的成像能力，具有高信噪比，成像速度以及空间和光谱分辨率。这种研究专用扫描仪将弥补NIH资助的生物医学和神经科学项目在校园内严重缺乏MRI访问的问题。此外，它将保持，加强和实现高质量的生物医学研究在康奈尔大学。3 T MRI扫描仪将成为康奈尔大学伊萨卡校区人类生态学院内的MRI核心设施。已为3 T MRI扫描仪的操作分配了空间和大量基础设施。3 T MRI扫描仪的采购、现场准备和安装总成本约为280万美元。除了从这个提案中要求的200万美元，大学（研究副教务长，人类生态学院，兽医学院，工程学院，艺术与科学学院和生物医学工程系）已承诺的资金和资源，以支付与此购买相关的剩余费用，以及最初的两年操作。康奈尔大学MRI核心设施的使命是促进非侵入性成像技术的发展和协同应用，以广泛的医学研究学科。MRI核心的组织、人员配备、设备采购和运营资金都旨在确保这一使命的成功。目前，有22个活跃的NIH项目（17个R 01，2个R21，1个R 03和2个合同）大量使用磁共振成像。此外，该MRI核心设施将增强/启用20项待定的NIH赠款提案。所要求的3 T MRI扫描仪将提供从小鼠到人类成像所需的平衡技术。它纳入校园范围内的核心研究设施是成功地进行和扩大NIH资助的尖端成像研究计划在我们的机构至关重要。 公共卫生相关性：

项目成果

Default network interactivity during mentalizing about known others is modulated by age and social closeness.

在对已知他人进行心智化过程中，默认的网络交互性受到年龄和社交亲密程度的调节。

• DOI: 10.1093/scan/nsaa067
• 发表时间: 2020
• 期刊: Social cognitive and affective neuroscience
• 影响因子: 4.2
• 作者: Laurita,AnneC;DuPre,Elizabeth;Ebner,NatalieC;Turner,GaryR;Spreng,RNathan
• 通讯作者: Spreng,RNathan

Auditory Target Detection Enhances Visual Processing and Hippocampal Functional Connectivity.

• DOI: 10.3389/fpsyg.2022.891682
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Moyal, Roy;Turker, Hamid B;Luh, Wen-Ming;Swallow, Khena M
• 通讯作者: Swallow, Khena M

Salience network engagement with the detection of morally laden information.

显着网络参与检测充满道德的信息。

• DOI: 10.1093/scan/nsx035
• 发表时间: 2017
• 期刊: Social cognitive and affective neuroscience
• 影响因子: 4.2
• 作者: Sevinc,Gunes;Gurvit,Hakan;Spreng,RNathan
• 通讯作者: Spreng,RNathan

Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).

通过连续定量磁化率绘图 (QSM) 测量新的增强型多发性硬化症 (MS) 病变磁化率的纵向变化。

• DOI: 10.1002/jmri.25144
• 发表时间: 2016-08
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Zhang Y;Gauthier SA;Gupta A;Comunale J;Chia-Yi Chiang G;Zhou D;Chen W;Giambrone AE;Zhu W;Wang Y
• 通讯作者: Wang Y

Mind the gap: Congruence between present and future motivational states shapes prospective decisions.

注意差距：当前和未来动机状态之间的一致性决定了未来的决策。

• DOI: 10.1016/j.neuropsychologia.2019.107130
• 发表时间: 2019
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Setton,Roni;Fisher,Geoffrey;Spreng,RNathan
• 通讯作者: Spreng,RNathan