Fogarty International Training Program in HIV- and AIDS-Associated Malignancies

描述（由申请人提供）：本申请建议继续和扩大Fogarty国际培训计划在艾滋病毒和艾滋病相关肿瘤。内布拉斯加州福格蒂培训计划的总体目标是在内布拉斯加大学及其美国合作机构为赞比亚和中国的生物医学科学家和医疗保健提供者提供培训，以提高他们在艾滋病毒和艾滋病相关恶性肿瘤方面进行高质量生物医学，行为和预防研究的专业知识和能力。我们的目标是继续培训研究员应用分子技术和新的医学方法，以了解艾滋病毒和其他与艾滋病有关的癌症病毒如何引起疾病，并培训研究员采用检测/预防疾病传播和与艾滋病有关的恶性肿瘤发展的战略，同时扩大我们目前的培训活动，以包括艾滋病毒和艾滋病相关的恶性肿瘤的治疗和与长期长期监测和管理受感染和治疗的个人。这些目标将通过以下具体目标实现：1）在内布拉斯加大学提供密集的学术指导，导致硕士，M.P.H.和博士生物医学科学学位;（2）为研究员提供机会，参加内布拉斯加大学、伯明翰亚拉巴马大学和迈阿密大学的生物医学研究轮换，以调查艾滋病毒、人乳头瘤病毒、卡波西肉瘤相关疱疹病毒和爱泼斯坦巴尔病毒在艾滋病相关恶性肿瘤发展中的作用，并进行检测病原体和监测艾滋病毒基因型的先进实验室方法培训; 3）为研究员提供机会，参加迈阿密大学艾滋病、抗病毒治疗和艾滋病相关恶性肿瘤临床管理的轮换; 4）在内布拉斯加大学和伯明翰的亚拉巴马大学提供艾滋病毒/艾滋病和艾滋病相关恶性肿瘤的流行病学和社会行为方面的培训，以改善-国家数据分析，促进公共卫生干预战略的制定和评价; 5）提供流行病学、行为干预、将由回国的研究员为国内临床医生和公共卫生人员的目标受众组织的培训和实验室技术。内布拉斯加州病毒学中心是全国最重要的病毒学研究和培训中心之一，将继续管理该项目。这一方案已取得势头，并成功地满足了艾滋病教育和预防方面的迫切需要。在未来五年，该计划将继续这一势头，并解决一个新的需求-基础设施和专业知识的紧迫性，以应对抗逆转录病毒治疗计划的规模扩大。

DESCRIPTION (provided by applicant): This application proposes to continue and to expand the Fogarty International Training Program in HIV- and AIDS-Associated Malignancies. The overall goal of the Nebraska Fogarty Training Program is to provide training at the University of Nebraska and its collaborating U.S. institutions for Zambian and Chinese biomedical scientists and health care providers to increase their expertise and capability to perform high quality biomedical, behavioral, and preventative research in HIV- and AIDS-associated malignancies. Our objective is to continue to train fellows to apply molecular techniques and new medical approaches to understand how HIV and other AIDS-associated cancer viruses cause diseases and train fellows in strategies used to detect/prevent disease transmission and the development of AIDS-related malignancies, while expanding our current training activities to include treatment of HIV- and AIDS-associated malignancies and issues related to the long-term monitoring and management of infected and treated individuals. These objectives will be achieved through the following specific aims: 1) Provide intensive academic instruction at the University of Nebraska leading to M.S., M.P.H., and Ph.D. degrees in biomedical science; 2) Provide opportunities for fellows to participate in biomedical research rotations at the University of Nebraska, the University of Alabama at Birmingham, and the University of Miami to investigate the role of HIV, Human Papilloma Virus, Kaposi's sarcoma-associated Herpes virus, and Epstein Barr virus in the development of AIDS-associated malignancies, and train in advanced laboratory methods to detect pathogens and monitor HIV genotypes; 3) Provide opportunities for fellows to participate in rotations in the clinical management of AIDS, anti-viral treatments, and AIDS-associated malignancies at the University of Miami; 4) Provide training in epidemiology and socio-behavioral aspects of HIV-AIDS and AIDS-associated malignancies at the University of Nebraska and the University of Alabama at Birmingham to improve in-country data analysis and facilitate the development and evaluation of public health intervention strategies; 5) Provide in-country courses and workshops in epidemiology, behavioral interventions, and laboratory techniques that will be organized by returning fellows for a target audience of in-country clinicians and public health personnel. The Nebraska Center for Virology, one of the nation's premier virology research and training centers, will continue to administer the program. This program has gained momentum and is successfully addressing urgent needs in AIDS education and prevention. Over the next five years, the program will continue this momentum and address a new need - the urgency for infrastructure and expertise to deal with the scale up of the antiretroviral treatment- program.