INTERNATIONAL TRAINING PROGRAM IN EPIDEMIOLOGY OF AIDS

艾滋病流行病学国际培训计划

• 批准号: 7637884
• 负责人: QUARRAISHA ABDOOL KARIM
• 金额: $ 70.75万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7637884
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adverse event; Advisory Committees; African; Biological; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Classification; Clinical; Clinical Trials; Country; Educational process of instructing; Epidemic; Epidemiology; Equilibrium; Ethics; Faculty; Funding; Future; General Practitioners; Goals; Grant; HIV; HIV vaccine; Impact evaluation; India; Institution; International; Leadership; Learning; Link; Mentors; Mentorship; Monitor; Nature; Paper; Pathogenesis; Physicians; Positioning Attribute; Prevention Research; Program Evaluation; Public Health; Public Health Nurses; Public Health Nursing; Publications; Recruitment Activity; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Science; Secure; South Africa; Southern Africa; Structure; Training; Training Programs; Tuberculosis; United States National Institutes of Health; Upper arm; Vaccine Clinical Trial; Vaccines; Work; Writing; base; clinical epidemiology; design; experience; human subject protection; knowledge base; medical schools; meetings; microbicide; pathogen; pediatrician; post-doctoral training; programs; quality assurance; response; scale up; skills; success; treatment program

DESCRIPTION (provided by applicant): The proposed training program builds on the successes and lessons of the previous 10 years as it takes a major leap forward. The growing research infrastructure, the growing local expertise, growing NIH funded research opportunities create a new set of challenges and opportunities for this hitherto successful AIDS/TB training program as the program adapts in response to meet the existing and emerging research training needs in South Africa and the region. The past 44 long-term and 69 short-term trainees of the program have been scientifically productive (515 publications including papers in Science, Nature, and Lancet), have made major new scientific contributions, have been instrumental to South Africa's success in securing NIH and other international grants and have taken up several key leadership positions. The continuum of training, research, and mentoring between the US and SA in the previous cycle has already gone some way towards equalizing the partnership between the US and South African but more still needs to be done, especially as the challenge of training for treatment provision and treatment program evaluations becomes more immediate. The emphasis of the program in this current cycle will be to identify critical gaps in existing centers of research excellence in South Africa and recruit, train and mentor appropriate enthusiastic, bright young and established mid-level investigators to provide them with the knowledge base and skills needed for the design and conduct of large-scale clinical trials (esp for vaccines and microbicides); pathogenesis studies, studies on the HIV/TB interaction and evaluation of the impact of ARV treatment. The goal is to strengthen existing and expand the number of independent HIV-related research teams in South Africa; strengthen South Africa's capacity to assume more of the country's and region's training needs and developing the skills needed to operationalize, implement and monitor the South African scale-up of AIDS treatment. Guided by the ongoing assessment of training priorities and with careful oversight from a balanced US-SA Scientific Advisory Committee, we will continue to provide as appropriate a variety of short-to-medium, and long-term training opportunities in the US and South Africa. Priority will be given to trainees from recognized AIDS research groups. Vigorous effort will go towards equalization of the training opportunities between the US and South Africa. This includes the establishment of a high quality masters program in epidemiology in South Africa taught initially jointly by US and South African faculty. A rich tapestry of AIDS and TB projects funded by NIH, CDC, and others offer diverse training and research opportunities to trainees for their placements. Overall, this program is designed to increase the number of independent established AIDS and TB researchers in South Africa so that there is local critical mass for future in-country mentorship and training. While this is a long-term goal, the proposed program sets about this task well armed with the most valuable lessons learnt in the last 5 years such as the importance of ongoing in-country mentorship, guidance and support, assistance with grant writing, and recruitment of candidates who are already in productive research groups.

描述（由申请人提供）：拟议的培训计划建立在过去10年的成功和教训的基础上，因为它需要一个重大的飞跃。 不断增长的研究基础设施，不断增长的本地专业知识，不断增长的NIH资助的研究机会，为迄今为止成功的艾滋病/结核病培训计划创造了一系列新的挑战和机遇，因为该计划适应于满足南非和该地区现有的和新出现的研究培训需求。该计划过去的44名长期和69名短期受训人员在科学上富有成效（515篇出版物，包括《科学》、《自然》和《柳叶刀》上的论文），做出了重大的新科学贡献，对南非成功获得NIH和其他国际赠款起到了重要作用，并担任了几个关键的领导职务。在上一个周期中，美国和南非之间的培训，研究和指导的连续性已经在一定程度上平衡了美国和南非之间的伙伴关系，但仍然需要做更多的工作，特别是因为治疗提供和治疗计划评估的培训挑战变得更加紧迫。 该计划在当前周期的重点将是确定南非现有卓越研究中心的关键差距，并招募，培训和指导适当的热情，聪明的年轻和成熟的中层研究人员，为他们提供设计和进行大规模临床试验所需的知识基础和技能（特别是疫苗和杀微生物剂）;发病机理研究，艾滋病毒/结核病相互作用研究和抗逆转录病毒治疗效果评估。目标是加强南非现有的艾滋病毒相关独立研究小组并扩大其数量;加强南非承担更多国家和区域培训需求的能力，并发展必要的技能，以操作、实施和监测南非扩大艾滋病治疗的工作。 在对培训优先事项进行持续评估的指导下，并在一个平衡的US-SA科学咨询委员会的仔细监督下，我们将继续在美国和南非酌情提供各种短期到中期和长期的培训机会。来自认可的艾滋病研究团体的学员将获得优先考虑。美国和南非之间的培训机会将得到均等化。这包括在南非建立一个高质量的流行病学硕士课程，最初由美国和南非教师联合授课。由美国国立卫生研究院、疾病预防控制中心和其他机构资助的艾滋病和结核病项目丰富多样，为实习生提供了各种培训和研究机会。总体而言，该计划旨在增加南非独立的艾滋病和结核病研究人员的数量，以便为未来的国内指导和培训提供当地的临界质量。虽然这是一个长期目标，但拟议的计划在过去5年中吸取了最有价值的经验教训，如持续的国内导师，指导和支持的重要性，资助写作的援助，以及已经在生产研究小组的候选人的招聘。