Columbia University-Southern African AIDS International Training/Research Program

哥伦比亚大学-南部非洲艾滋病国际培训/研究项目

基本信息

批准号：
7916950
负责人：
QUARRAISHA ABDOOL KARIM
金额：
$ 73.15万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-06-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7916950
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Acute Address Advisory Committees Africa African Anti-Retroviral Agents Area Breast Feeding Centers of Research Excellence Collaborations Consultations Country Decision Making Drug Resistant Tuberculosis Epidemic Equilibrium Faculty Funding Future Goals Grant HIV HIV Infections HIV vaccine Health Infection International AIDS Investigator-Initiated Research Joints Journals Knowledge Leadership Learning Lesotho Medical Students Mentorship Monitor Multicenter Studies Namibia Nature Paper Pathogenesis Peer Review Policy Maker Prevention Publishing Reliance Research Research Infrastructure Research Personnel Research Training Resources Role Science South Africa Southern Africa Swaziland Technology Training Training Programs Tuberculosis Universities Writing arm base meetings microbicide novel strategies pandemic disease prevent programs public health relevance response scale up skills success treatment program vector transmission

项目摘要

DESCRIPTION (provided by applicant): This proposed training program builds on the successes and lessons of the previous 14 years to meet the new emerging and evolving challenges of a maturing HIV epidemic in southern Africa, the epicenter of the global HIV pandemic. The 125 long-term and 186 short-term trainees of the current program continue to have a major impact through their leadership roles globally and locally, as their research generates new knowledge in areas such as HIV pathogenesis in acute HIV infection, new prevention technologies (including antiretrovirals to prevent breastfeeding transmission, vector-based HIV vaccines and antiretroviral microbicides), and new approaches to treating HIV-TB co-infection. The trainees have published 894 peer- reviewed papers including several in high impact journals like Science, Nature and the Lancet. The emergence of HIV-associated drug-resistant tuberculosis (TB), the implementation of the largest AIDS treatment program in the world and the dire need for evidence to guide decision-making as South Africa transitions from its denialist past to a politically enlightened future under a new Minister of Health, have created a set of new challenges and opportunities for the next cycle of this program. Building on the substantive science base, extensive research infrastructure and local expertise created through this program, the rich tapestry of in-country AIDS and TB studies, the strategic collaborations within and outside South Africa, and the new opportunities to leverage funding from other agencies, the proposed program will continue to identify trainees with the most potential, offer them high quality training both in South Africa and the USA and provide them with ongoing support to create a critical mass for an effective response to the HIV and TB epidemics in southern Africa. The proposed program sets about this task well armed with the most valuable lessons learnt in the past decade such as the importance of long-term in-country mentorship, ongoing training in grant writing and administration, strategic partnering to maximize training opportunities, recruitment of candidates in consultation with local productive research groups and the value of having joint USA and South African faculty in raising the standard of in-country training. Guided by the ongoing assessment of training priorities and with careful oversight from a balanced US- SA Training Advisory Committee, that includes several previous trainees who are now senior investigators, we will continue to provide, as appropriate, a variety of short-to-medium, and long-term training opportunities in the USA, South Africa, Swaziland, Namibia and Lesotho. The emphasis of the program in the next cycle is to i) address critical training gaps in existing HIV and TB centers of research excellence in South Africa to meet the new emerging challenges in the HIV epidemic, ii) provide support and mentorship for young investigators, especially medical students, and iii) provide the training critical to the efforts of South African AIDS research to transition from the current reliance on multicenter studies to a more sustainable balanced portfolio with increased levels of investigator-initiated research. The goal is to strengthen and expand the existing number of independent HIV and TB research teams in southem Africa; strengthen local capacity to assume more of the region's training needs and developing the skills needed to assist policy makers with evidence to implement and monitor the scale-up of HIV/AIDS prevention and treatment programs. PUBLIC HEALTH RELEVANCE: This program is a critical training resource for strengthening the institutional science base for undertaking pivotal HIV and TB research in the epicenter of the HIV pandemic to enhance responses to the HIV and TB epidemics in South Africa, Swaziland, Lesotho and Namibia

描述（由申请人提供）：该拟议的培训计划以前14年的成功和教训为基础，以应对南部非洲成熟的HIV流行的新的新兴和不断发展的挑战，这是全球HIV大流行的中心。当前计划的125名长期和186名短期学员继续通过其全球和本地领导角色产生重大影响，因为他们的研究在诸如急性HIV感染，新的预防技术（包括抗逆转录病毒的抗艾滋病毒发病机理）中产生了新知识（包括抗逆转录病毒，包括基于媒介的Hive疫苗，基于媒介的HIV疫苗和抗抗逆转录病毒，以治疗hiveRortoral-facretiver-infreciral-infbiral-factriv-forefbriv-infbriv-tobriv-tobriv-infbriv-tobebiral-factriv-forefbriv-to）和新近距离近距离探测。学员已经发表了894篇同行评审的论文，其中包括科学，自然和柳叶刀等高影响力期刊。与HIV相关的抗药性结核病（TB）的出现，世界上最大的艾滋病治疗计划的实施以及迫切需要指导决策，因为南非从其否定主义的过去转变为在政治上启发的卫生部长的未来，为新的挑战和下一个周期创造了新的挑战和机会。在实质性科学基础上，通过该计划创建的广泛的研究基础设施和本地专业知识，丰富的诸多艾滋病和结核病研究，南非内外和外部的战略合作以及在其他机构中利用其他机构的资金的新机会，拟议的计划将继续为他们提供高质量的培训，为他们提供高质量的培训，为他们提供质量的群体，为他们提供质量的群体，在美国提供良好的培训，为他们提供了一定的范围，为他们提供质量的群体，为他们提供了一定的群体，那么在美国的范围内将提供良好的质量，从而为他们提供质量的培训，以使他们有效地培训，从而为他们提供质量的范围，从而为他们提供质量的群体，从而为美国提供良好的培训，从而为美国提供良好的培训，这是在美国范围内和外部提供的新机会和南部非洲的结核病流行病。拟议的计划为这项任务设定了良好的武装，其中包括过去十年中最有价值的经验教训，例如长期国家指导的重要性，正在进行的赠款写作和管理方面的持续培训，战略性合作，以最大程度地提高培训机会，招募候选人在与当地生产研究小组协商中招募候选人以及在美国联合美国和南非培训中提高培训的价值。在对培训优先级的持续评估以及对平衡的美国SA培训咨询委员会的仔细监督下的指导下，其中包括几位现在是高级调查人员的学员，我们将继续在美国，南非，斯威士兰，纳米比亚和Lesotho提供各种短期到中等的培训和长期培训机会。该计划在下一个周期中的重点是i）解决南非现有艾滋病毒和结核病研究中心的关键培训差距，以应对艾滋病毒流行病的新挑战，ii）为年轻的研究者（尤其是医学生）提供支持和iii的支持和指导，从而为南非的努力提供了更多的培训，从而使对当前的研究范围的努力提供了更多的培训。研究人员发起的研究。目的是加强和扩大南非南部的独立艾滋病毒和结核病研究团队的现有数量；增强当地能力，以实现该地区的更多培训需求，并开发帮助决策者提供证据所需的技能，以实施和监控艾滋病毒/艾滋病预防和治疗计划的规模。公共卫生相关性：该计划是一种关键的培训资源，可在HIV大流行中加强对艾滋病毒震中进行关键艾滋病毒和结核病研究的机构科学基础，以增强对南非，斯威士兰，莱索托和纳米比亚的艾滋病毒和结核病流行的反应