Self-Healing Composites via Novel Biomolecular Design and Processing

描述（由申请人提供）：该申请涉及广泛的挑战领域（13）智能生物材料-治疗学和特定挑战主题，13- de -101*新型自我修复智能牙科和生物修复材料。用合成材料有效地修复和替换骨骼组织仍然是当今医疗保健领域面临的巨大挑战之一。尽管金属骨科和牙科植入物在现代骨科和牙科临床实践中得到了广泛的应用和成功，但它们仍然是它们所要替代的组织的不良替代品。牙齿和骨骼的天然矿化组织是无机和有机相的混合物，经过数百万年的进化，它们变得轻便、坚固、耐损伤，并具有自愈能力。尽管在过去的三十年里，复合材料科学和技术的进步取得了巨大的进步，但在体内应用方面，复合材料的性能只取得了微小的进步。具体来说，用能够承受人体内部恶劣条件和极端循环载荷条件的合成材料替代承重骨组织，并持续使用数年甚至数十年，仍然是一个未实现的目标。我们的愿景是通过结合创新的生物启发聚合物设计和合成，有机-无机界面键合的基础研究以及复合材料加工的优雅方法来应对这一挑战。我们假设我们的生物启发，统一的方法将导致具有自我修复能力的新型高强度复合材料。受自然界中发现的自愈材料的启发，有机相和无机相的组成将被设计成赋予独特的自愈特性，并将使用独特的复合加工方法制造，以产生坚固，高强度的复合材料。这项研究将引领下一代骨和牙齿替代复合材料的发展。在这个项目中，我们采用了一种受生物学启发的方法来开发具有高强度和高损伤容忍度的复合材料，因为它具有自愈特性。这项研究可能会导致新一代的临床材料替代骨和牙齿。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (13) Smart Biomaterials - Theranostics and specific Challenge Topic, 13-DE-101* Novel Self-Healing Smart Dental and Bio-Restorative Materials. Effective repair and replacement of skeletal tissue by synthetic materials remains one of the great challenges in healthcare today. Although metallic orthopedic and dental implants enjoy widespread use and success in modern orthopedic and dental clinical practice, they remain poor substitutes for the tissues they are intended to replace. Natural mineralized tissues of the teeth and bones are composites of inorganic and organic phases, having evolved over many millions of years to be lightweight, strong, damage tolerant, and capable of self-healing. Despite significant efforts toward improving composite science and technology over the last thirty years, only marginal improvements in composite performance have been realized for in-vivo applications. Specifically, replacement of load-bearing skeletal tissues with synthetic materials capable of withstanding the harsh conditions inside the human body and extreme cyclic loading conditions for years or even decades of continuous service remains an unmet goal. Our vision is to meet this challenge by combining innovative biologically inspired polymer design and synthesis, fundamental studies of bonding at the organic-inorganic interface, and an elegant approach to composite processing. We hypothesize that our bioinspired, unified approach will lead to novel high strength composite materials with self-healing capacity. Inspired by self- healing materials found in nature, the composition of organic and inorganic phases will be designed to impart unique self-healing characteristics and will be fabricated using unique composite processing methodology to yield robust, high-strength composites. This study will lead the way toward next generation composite materials for replacement of bone and teeth. In this project we employ a biologically inspired approach to the development of composite materials with high strength and high damage tolerance as a result of self-healing properties. This study may lead to a new generation of clinical materials for replacement of bone and teeth.