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Development of Orthographic Knowledge: fMRI Studies

正字法知识的发展：功能磁共振成像研究

基本信息

批准号：
7900850
负责人：
Bradley L Schlaggar
金额：
$ 18.9万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7900850
关键词：
Address Adult Anatomy Brain Child Clinical Cognition Cognition Disorders Complex Country Data Dependence Development Developmental reading disorder Dimensions Economics Education Elderly Environment Foundations Functional Magnetic Resonance Imaging Goals Growth Human Human Development Independent Scientist Award Individual Intervention Investigation Knowledge Language Learning Left Letters Link Motivation Names Natural Selections Neuroanatomy Neurobiology Orthography Pediatric Neurology Performance Persons Physicians Population Principal Investigator Process Psycholinguistics Reader Reading Reading Disorder Recording of previous events Research Research Personnel Research Support Resolution Resources Schools Scientist Structure System Training Translation Process Universities Visual Visual system structure Washington Work Writing base career cognitive neuroscience developmental neurobiology experience illiteracy improved insight lexical processing literate neuroimaging neuromechanism object recognition patient population phonology prevent remediation research study skills social sound spelling success tool

项目摘要

DESCRIPTION (provided by applicant): An understanding of how skilled reading is achieved is fundamental to generating improved strategies for reading education, and toward identifying, treating, and preventing developmental deficits in reading and spelling. Skilled reading is the consequence of a complex interplay of experience and the development of neurobiological substrates. Investigation of the developmental neurobiology of reading is likely to yield important insight into its skilled performance. This proposal focuses on the linking of visual orthographic (i.e., letters) information to phonology, critical in the acquisition of reading skills. By extension, characterization of the developmental functional neuroanatomy of the relationship between orthographic and phonologic processing will provide an important context for studying the cognitive neuroscience of typical (and atypical) reading development. This proposal aims to identify and characterize the developmental functional anatomy of orthographic knowledge, and of the spelling-to-sound translation processes involved in word reading. The principal investigator (PI) is an academic physician-scientist trained in pediatric neurology and specializing in disorders of cognitive development. Although the PI has substantial experience in developmental neurobiology and the functional neuroimaging of typically and atypically developing children, the added dimension of integrating developmental psycholinguistics supported by this Research Career Award (K02) should provide important insights into mechanisms of the developmental neurobiology of reading and significantly aid the PI in further developing his independent research career. Washington University possesses excellent resources in cognitive neuroscience, access to patient populations, and expert researchers in developmental psycholinguistics and represents an ideal environment for the PI to complete the goals of this proposal.

描述(由申请人提供)：对如何获得熟练阅读的理解是制定阅读教育改进策略的基础，并有助于识别、治疗和预防阅读和拼写方面的发展缺陷。熟练阅读是经验和神经生物学底物发展的复杂相互作用的结果。对阅读的发展神经生物学的研究可能会对阅读的熟练表现有重要的洞察力。这项建议侧重于将视觉正字法(即字母)信息与音韵学联系起来，这对阅读技能的获得至关重要。发展功能神经解剖学对正字法加工和语音加工之间关系的表征将为研究典型(和非典型)阅读发展的认知神经科学提供重要的背景。这项建议旨在识别和表征拼写知识的发育功能解剖学，以及单词阅读中涉及的拼写到声音翻译过程。首席研究员(PI)是一位受过儿科神经学训练的学术内科科学家，专门研究认知发展障碍。尽管该协会在发育神经生物学和典型和非典型发育儿童的功能神经成像方面拥有丰富的经验，但由本研究事业奖(K02)支持的整合发展心理语言学的额外维度应该会为阅读的发展神经生物学机制提供重要的见解，并在很大程度上帮助该协会进一步发展他的独立研究事业。华盛顿大学在认知神经科学、接触患者群体和发展心理语言学方面拥有极好的资源，是PI完成这一提议目标的理想环境。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Functional Neuroimaging Insights Into the Development of Skilled Reading.

DOI：
10.1111/j.1467-8721.2009.01599.x
发表时间：
2009-02-01
期刊：
Current directions in psychological science
影响因子：
7.2
作者：
Schlaggar BL;Church JA
通讯作者：
Church JA

Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity.

DOI：
10.1093/brain/awn223
发表时间：
2009-01
期刊：
BRAIN
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.

The "Task B problem" and other considerations in developmental functional neuroimaging.

DOI：
10.1002/hbm.21036
发表时间：
2010-06
期刊：
HUMAN BRAIN MAPPING
影响因子：
4.8
作者：
Church, Jessica A.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.

Matching is not naming: a direct comparison of lexical manipulations in explicit and implicit reading tasks.

DOI：
10.1002/hbm.22077
发表时间：
2013-10
期刊：
HUMAN BRAIN MAPPING
影响因子：
4.8
作者：
Vogel, Alecia C.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.

Identifying Basal Ganglia divisions in individuals using resting-state functional connectivity MRI.

DOI：
10.3389/fnsys.2010.00018
发表时间：
2010
期刊：
Frontiers in systems neuroscience
影响因子：
3
作者：
Barnes KA;Cohen AL;Power JD;Nelson SM;Dosenbach YB;Miezin FM;Petersen SE;Schlaggar BL
通讯作者：
Schlaggar BL