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Child Neurologist Career Development Program

儿童神经科医生职业发展计划

基本信息

批准号：
10663813
负责人：
Bradley L Schlaggar
金额：
$ 397.94万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10663813
关键词：
Adult Advisory Committees Affect Articulation Award Child Childhood Development Development Plans Diagnosis Discipline Disease Educational Curriculum Faculty Funding Grant Individual Institution Intervention K-Series Research Career Programs Leadership Letters Measures Mentored Clinical Scientist Development Program Mentors National Institute of Neurological Disorders and Stroke Nervous System Neurologist Neurology Neurosciences Pediatric Neurology Physicians Population Prevention Program Development Program Evaluation Recommendation Research Research Project Grants Research Support Review Committee Scientist Structure Time United States National Institutes of Health Work career career development clinical training curriculum enhancement feasibility research improved innovation meetings member programs research and development success supportive environment symposium webinar

项目摘要

Project Summary / Abstract Disorders of the developing nervous system are common, affecting roughly 15% of the population. To improve the lives of children (and adults) with such disorders, we are in critical need of an enhanced pipeline of child neurology physician-scientists who will drive the innovative research necessary to lead to improvements in prevention, diagnosis and intervention. We propose, in this renewal application for the Child Neurologist Career Development Program (CNCDP-K12), to build upon our extant program, providing intensive, mentored career development for pediatric neurologists committed to being independently funded physician-scientists. This NINDS funded program is the nationalized version of the Neuroscience Academic Development Award (NSADA), a program granted to individual institutions. While the NSADA supported the research career development of numerous child neurologists, the program has under-delivered at the national level, as measured by the number of funded scholars to receive individual K awards, arguably due to its yoking to up to 10 specific institutions. By contrast, the CNCDP has a single Program Director with an Executive Leadership comprising 8 highly collaborative physician-scientist pediatric neurologists who are national leaders in the discipline. The CNCDP has 2 faculty committees: a 15 member Scientific Advisory & Review Committee (SARC) and a 4 member National Advisory Committee (NAC). The faculty members comprising these committees, all accomplished physician- scientists with over 25% from non-pediatric neurology disciplines, have diverse sets of expertise. The SARC reviews scholar applicants/applications and serves as extra-institutional advisors. The NAC provides to the leadership ongoing critical evaluation of the program. Under the CNCDP, individual pediatric neurologists (within 3 years of completion of clinical training) from any academic institution in the US can apply. The applicant must demonstrate a high quality and feasible research project, a robust career development plan, and institutional environment supportive of physician scientist career development, and an institutional letter of support committing appropriate protected time to research and career development. The Annual Meeting, a 2.5 day retreat attended by all faculty, funded scholars, applicants, NIH staff, and others, constitutes a mechanism for intensive mentoring and career development through small group sessions, one-on-one meetings, scholar presentations of their work (with intensive focus on quality presentations and articulating specific aims), and other career-enhancing curriculum. Program curriculum is also provided year-round through webinars/video conference. At the Annual Meeting, the SARC reviews the applications and recommends typically 6 of the most meritorious for 3 years of funding. A total of 30 scholars (90 scholar-years) are to be funded. The CNCDP provides highly structured oversight of the scholars' progress as well as institutional and scholar commitment to the program's requirements. Success of the program will be measured by a high rate of both scholars and non-funded applicants achieving individual K level funding or the equivalent.

项目概要/摘要发育中的神经系统疾病很常见，影响大约 15% 的人口。改善患有此类疾病的儿童（和成人）的生活，我们迫切需要加强儿童治疗渠道神经病学医师科学家将推动必要的创新研究，以改善预防、诊断和干预。我们建议，在儿童神经科医生的续签申请中职业发展计划 (CNCDP-K12)，以我们现有计划为基础，提供强化的、有指导的致力于成为独立资助的医师科学家的儿科神经科医生的职业发展。这 NINDS 资助的项目是神经科学学术发展奖 (NSADA) 的国家化版本，授予个别机构的计划。虽然 NSADA 支持研究职业发展许多儿童神经科医生认为，根据获得个人 K 奖的受资助学者数量，可以说是因为该奖项与最多 10 个具体奖项挂钩机构。相比之下，CNCDP 只有一名项目总监，其执行领导层由 8 名成员组成高度合作的医师科学家儿科神经科医生，他们是该学科的国家领导者。全国人大常委会有 2 个教职委员会：一个由 15 名成员组成的科学咨询与审查委员会 (SARC) 和一个由 4 名成员组成的国家咨询委员会（NAC）。组成这些委员会的教职人员都是有成就的医生- 超过 25% 的科学家来自非儿科神经病学学科，拥有不同的专业知识。 SARC 评论学者申请人/申请并担任机构外顾问。 NAC 向领导层提供对该计划进行持续的批判性评估。根据 CNCDP，个体儿科神经科医生（在 3 年内）完成临床培训）来自美国任何学术机构的都可以申请。申请人必须证明高质量、可行的研究项目、健全的职业发展计划和制度环境支持医师科学家的职业发展，以及机构的支持信承诺适当的受保护的研究和职业发展时间。年会是一次为期 2.5 天的静修会，所有教职员工都参加了资助的学者、申请人、NIH 工作人员和其他人，构成了强化指导和职业发展的机制通过小组会议、一对一会议、学者介绍他们的工作（与重点关注高质量的演讲和阐明具体目标）以及其他职业提升课程。项目课程还通过网络研讨会/视频会议全年提供。年会上， SARC 会对申请进行审查，并通常会推荐 6 名最优秀的申请者获得 3 年的资助。一个总共将资助 30 名学者（90 个学年）。 CNCDP 提供高度结构化的监督学者的进步以及机构和学者对项目要求的承诺。成功的该项目将通过学者和非资助申请人获得个人 K 的高比例来衡量级资金或同等资金。

项目成果

期刊论文数量（68）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Neurodevelopmental and Motor Phenotype of SCA21 (ATX-TMEM240).

DOI：
10.1177/0883073820943488
发表时间：
2020-12
期刊：
Journal of child neurology
影响因子：
1.9
作者：
Burdekin ED;Fogel BL;Jeste SS;Martinez J;Rexach JE;DiStefano C;Hyde C;Safari T;Wilson RB
通讯作者：
Wilson RB

Identification of novel candidate disease genes from de novo exonic copy number variants.

DOI：
10.1186/s13073-017-0472-7
发表时间：
2017-09-21
期刊：
Genome medicine
影响因子：
12.3
作者：
Gambin T;Yuan B;Bi W;Liu P;Rosenfeld JA;Coban-Akdemir Z;Pursley AN;Nagamani SCS;Marom R;Golla S;Dengle L;Petrie HG;Matalon R;Emrick L;Proud MB;Treadwell-Deering D;Chao HT;Koillinen H;Brown C;Urraca N;Mostafavi R;Bernes S;Roeder ER;Nugent KM;Bader PI;Bellus G;Cummings M;Northrup H;Ashfaq M;Westman R;Wildin R;Beck AE;Immken L;Elton L;Varghese S;Buchanan E;Faivre L;Lefebvre M;Schaaf CP;Walkiewicz M;Yang Y;Kang SL;Lalani SR;Bacino CA;Beaudet AL;Breman AM;Smith JL;Cheung SW;Lupski JR;Patel A;Shaw CA;Stankiewicz P
通讯作者：
Stankiewicz P

Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice.

出生后第 10 天小鼠的齿状回中雌性和雄性小胶质细胞没有差异。

DOI：
10.1016/j.neulet.2023.137171
发表时间：
2023
期刊：
Neuroscience letters
影响因子：
2.5
作者：
Guez-Barber,Danielle;Colon,LoriannaM;Raphael,Dana;Wragan,MaxA;Yun,Sanghee;Eisch,AmeliaJ
通讯作者：
Eisch,AmeliaJ

Haem's relevance genuine? Re-visiting the roles of TANGO2 homologues including HRG-9 and HRG-10 in C. elegans.

海姆的相关性是真的吗？

DOI：
10.1101/2023.11.29.569072
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Sandkuhler,SarahE;Youngs,KaylaS;Owlett,Laura;Bandora,MonicaB;Naaz,Aaliya;Kim,EuriS;Wang,Lili;Wojtovich,AndrewP;Gupta,VandanaA;Sacher,Michael;Mackenzie,SamuelJ
通讯作者：
Mackenzie,SamuelJ

Neonatal genetic epilepsies display convergent white matter microstructural abnormalities.

新生儿遗传性癫痫表现出聚合性白质微结构异常。

DOI：
10.1111/epi.16735
发表时间：
2020
期刊：
Epilepsia
影响因子：
5.6
作者：
SandovalKaramian,AmandaG;Wusthoff,CourtneyJ;Boothroyd,Derek;Yeom,KristenW;Knowles,JulietK
通讯作者：
Knowles,JulietK