LONGITUDINAL EFFECTS OF TREATMENT ON BRAIN FUNCTION IN CHILDREN WITH TOURETTE SYN

治疗对抽动秽语综合症儿童脑功能的纵向影响

• 批准号: 8115128
• 负责人: Bradley L Schlaggar
• 金额: $ 22.57万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115128
• 关键词: Address; Adolescent; Affect; Aftercare; Age; Basal Ganglia; Behavioral; Biological Markers; Brain; Brain region; Child; Childhood; Chronic; Clinical; Corpus striatum structure; Development; Disease; Early Diagnosis; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Genetic; Gilles de la Tourette syndrome; Goals; Individual; Individual Differences; Intervention; Magnetic Resonance Imaging; Measures; Methods; Motor Tics; Participant; Pathway interactions; Patients; Pattern; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Physicians; Process; Psychometrics; Quality of life; Reaction Time; Regulation; Rest; Scanning; Severities; Structure; Symptoms; System; Techniques; Testing; Time; Vocal Tics; base; cognitive function; effective therapy; executive function; experience; frontal lobe; improved; mind control; neuropsychiatry; outcome forecast; public health relevance; treatment effect

DESCRIPTION (provided by applicant): Tourette Syndrome (TS) is a common genetic pediatric neuropsychiatric disorder. Manifest as chronic motor and vocal tics, it affects approximately 0.3-1% of children, with significant negative impact on quality of life. TS is associated with deficits in impulse regulation and executive control functions. The brain's executive control systems are thought to be anatomically separate from downstream moment-to-moment processing systems and to consist of networks of functionally diverse regions. The interactions of these control systems with processing systems have been implicated in TS. A key idea underlying this exploratory proposal is that TS arises from the atypical development of networks of control regions and their interactions, as opposed to the atypical functioning of any particular brain region. Medications that relieve tics in TS may also result in an improvement in control abilities, and a normalization of both evoked activity within control regions and of functional connectivity between regions comprising control networks. We hypothesis that the anomalous patterns of brain activation and functional connectivity observed in TS will be ameliorated by medications that treat TS. Understanding the brain's control networks are affected by medications may lay the foundation for earlier diagnosis and more effective therapies for TS and other pediatric neuropsychiatric disorders. PUBLIC HEALTH RELEVANCE: This proposal aims to use longitudinal task-based fMRI and functional connectivity MRI to characterize the development of control networks in pediatric Tourette Syndrome and how those networks respond to pharmacotherapeutic intervention. Understanding how networks of brain regions involved in control are affected by pharmacotherapy in patient with Tourette Syndrome may lay the foundation for earlier diagnosis, more accurate prognosis, and more effective therapies

描述（由申请人提供）：抽动秽语综合症（TS）是一种常见的遗传性小儿神经精神疾病。表现为慢性运动和发声抽搐，影响大约 0.3-1% 的儿童，对生活质量产生显着的负面影响。 TS 与冲动调节和执行控制功能的缺陷有关。大脑的执行控制系统被认为在解剖学上与下游的即时处理系统是分开的，并且由功能不同的区域的网络组成。这些控制系统与处理系统的相互作用与 TS 有关。这一探索性提议背后的一个关键思想是，TS 源于控制区域网络及其相互作用的非典型发展，而不是任何特定大脑区域的非典型功能。缓解 TS 抽动的药物也可能导致控制能力的改善，以及控制区域内诱发活动和构成控制网络的区域之间的功能连接的正常化。我们假设在 TS 中观察到的大脑激活和功能连接的异常模式将通过治疗 TS 的药物得到改善。了解大脑控制网络受药物影响可能为 TS 和其他小儿神经精神疾病的早期诊断和更有效的治疗奠定基础。 公共健康相关性：该提案旨在使用基于纵向任务的功能磁共振成像和功能连接磁共振成像来描述儿科抽动秽语综合征控制网络的发展以及这些网络如何响应药物治疗干预。了解抽动秽语综合征患者药物治疗如何影响参与控制的大脑区域网络可能为早期诊断、更准确的预后和更有效的治疗奠定基础