NIDCD P30 Core: Rocky Mountain Taste and Smell Center

NIDCD P30 核心：落基山味觉和嗅觉中心

• 批准号: 7852317
• 负责人: Diego Restrepo
• 金额: $ 21.28万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7852317
• 关键词: NIDCD; P30; Core; Rocky; Mountain

DESCRIPTION (provided by applicant): The proposed Rocky Mountain Taste and Smell Center (RMTSC) will encompass twelve principal investigators including scientists with a substantial record of accomplishment in the field of chemical senses as well as investigators with expertise in other areas of neurobiology. The overall goal of the RMTSC is to facilitate research in the chemical senses by providing communal resources and by bringing together productive investigators into a supportive, interactive environment. In order to obtain this overall goal, three interrelated specific aims are delineated: 1. Provide a focal point for increased interactions among participating investigators; 2. Enhance the research capabilities and infrastructure supporting the individual laboratories; 3. Facilitate entree of promising investigators into the study of chemical senses. In order to accomplish these goals, two Core service areas are proposed. Core A (Gene- Targeted/Transgenic Mouse Core; D. Restrepo and L. Sussel, directors) will develop and maintain transgenic/gene-targeted mice. Core B (Cellular Visualization and Analysis Core; Finger and Restrepo, directors) will provide advanced neurohistology, and cellular visualization services through an institutional multi-photon microscope facility. In addition, Core B will develop quantitative approaches for the rigorous analysis of 3-dimensional image data sets. These cores provide services not currently supported or available through the aegis of other grants and will thereby enhance the research capabilities of the participating investigators.

描述（由申请人提供）：拟议的落基山味觉和味觉中心（RMTSC）将包括12名主要研究人员，包括在化学感官领域有大量成就记录的科学家以及在神经生物学其他领域有专业知识的研究人员。RMTSC的总体目标是通过提供公共资源并将富有成效的研究人员聚集在一起，形成一个支持性的互动环境，以促进化学意义上的研究。为了实现这一总体目标，确定了三个相互关联的具体目标：1.为参与研究者之间增加互动提供一个协调中心; 2.加强研究能力和支持各个实验室的基础设施; 3.促进有前途的研究人员进入化学感官的研究。为了实现这些目标，提出了两个核心服务领域。核心A（基因靶向/转基因小鼠核心; D. Restrepo和L. Sussel，董事）将开发和维护转基因/基因靶向小鼠。核心B（细胞可视化和分析核心;手指和雷斯特雷波，董事）将提供先进的神经组织学，并通过机构的多光子显微镜设施细胞可视化服务。此外，核心B将开发用于三维图像数据集的严格分析的定量方法。这些核心项目提供了目前没有得到其他赠款支持或提供的服务，从而提高了参与研究的研究人员的研究能力。