NIDCD P30 Core: Rocky Mountain Taste and Smell Center

描述(由申请人提供)：拟建的落基山味觉与气味中心(RMTSC)将包括12名首席研究人员，其中包括在化学感官领域有丰富成就的科学家以及在神经生物学其他领域具有专业知识的研究人员。该中心的总体目标是通过提供公共资源和将富有成效的研究人员聚集到一个支持性的互动环境中，促进化学意义上的研究。为了实现这一总体目标，勾勒出了三个相互关联的具体目标：1.为参与的研究人员之间增加互动提供一个联络点；2.加强支持各个实验室的研究能力和基础设施；3.促进有前途的研究人员进入化学感官研究。为了实现这些目标，提出了两个核心服务领域。核心A(基因靶向/转基因小鼠核心；D.Restrepo和L.Sussel，董事)将开发和维持转基因/基因靶向小鼠。CORE B(细胞可视化和分析核心；Finger和Restrepo董事)将通过机构的多光子显微镜设施提供先进的神经组织学和细胞可视化服务。此外，核心B将开发用于对三维图像数据集进行严格分析的量化方法。这些核心提供的服务目前没有得到其他赠款的支持或提供，因此将加强参与调查人员的研究能力。

DESCRIPTION (provided by applicant): The proposed Rocky Mountain Taste and Smell Center (RMTSC) will encompass twelve principal investigators including scientists with a substantial record of accomplishment in the field of chemical senses as well as investigators with expertise in other areas of neurobiology. The overall goal of the RMTSC is to facilitate research in the chemical senses by providing communal resources and by bringing together productive investigators into a supportive, interactive environment. In order to obtain this overall goal, three interrelated specific aims are delineated: 1. Provide a focal point for increased interactions among participating investigators; 2. Enhance the research capabilities and infrastructure supporting the individual laboratories; 3. Facilitate entree of promising investigators into the study of chemical senses. In order to accomplish these goals, two Core service areas are proposed. Core A (Gene- Targeted/Transgenic Mouse Core; D. Restrepo and L. Sussel, directors) will develop and maintain transgenic/gene-targeted mice. Core B (Cellular Visualization and Analysis Core; Finger and Restrepo, directors) will provide advanced neurohistology, and cellular visualization services through an institutional multi-photon microscope facility. In addition, Core B will develop quantitative approaches for the rigorous analysis of 3-dimensional image data sets. These cores provide services not currently supported or available through the aegis of other grants and will thereby enhance the research capabilities of the participating investigators.