Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence

青春期的压力、神经发育和成瘾行为的出现

基本信息

  • 批准号:
    7874688
  • 负责人:
  • 金额:
    $ 24.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-30 至 2012-06-30
  • 项目状态:
    已结题

项目摘要

Stress, Neurodevelppment and the Emergence of Addictive Behaviors in Adolescence (Project 6 of 14): Adolescence is a critical period for the emergence of addictive behaviors that not only place adolescents at immediate risk for morbidity and for accidents, suicide, and violent behavior (the leading causes of death in this age group), but also contribute to lifelong increases in major medical morbidity and early mortality. Though childhood stress is known to be a major risk factor for the development of addictive behaviors in adolescence, there is a paucity of study of the mechanisms by which stress leads to the emergence of addictive behaviors in teens. Our pilot data suggest that childhood stress alters development of ventral prefrontal cortex (VPFC) control over amygdala and ventral striatum responses to emotional stimuli, resulting in excessive drive towards hedonic stimuli, impulsivity and addictive behaviors. This project establishes a new collaboration between co-Pis Drs. Blumberg and Mayes to bring together their respective expertise in multimodality magnetic resonance imaging (MRI) study of adolescent brain development and modeling the influences of psychosocial factors on the development of adaptive emotional and social behaviors in children and adolescents. This will provide unique opportunities to study how psychosocial stressors in childhood alter cortico-limbic development to contribute to the emergence of addictive behaviors in adolescence. This study team will include Drs. Kalmar, Mazure, Nicholls, Nolen-Hoeksema, Ryan, Wang and other consortium collaborators to integrate perspectives including Adolescent Medicine, Neurobiology, Neuroimaging, Neuropsychology, Pediatrics, Psychiatry, Psychology and Women's Health. Dr. Mayes has followed a unique cohort prospectively since birth, now entering adolescence, carefully characterized with biannual assessments for biopsychosocial factors. We plan to study 70 adolescents from this cohort, ages 14-17 years (50% girls): 35 with a history of childhood maltreatment and 35 without a history of maltreatment. Dr. Blumberg's group will perform functional MRI and diffusion tensor imaging to examine regional brain response to emotional stimuli within cortico-limbic circuitry, the functional connectivity between components within this circuitry, as well as the integrity of the structural white matter connections in the circuitry. Consortium core (Projects 13,14) measures of stress, biological factors and addictive behaviors will provide rich opportunities for study, including interactions between stress and genetic variations associated with biogenic amine regulation of the amygdala-ventral striatum-VPFC neural system (as in 2,3,7,8) in influencing the emergence of addictive behaviors. Collaboration with Drs. Potenza and Neumeister (7,8) will provide opportunities to examine similarities and differences between adolescents and adults, and novel treatments tested (5,9,10) will provide the basis for future innovative prevention and early intervention strategies.
压力,神经发育和青少年成瘾行为的出现(14个项目6):

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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HILARY Patricia BLUMBERG其他文献

HILARY Patricia BLUMBERG的其他文献

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{{ truncateString('HILARY Patricia BLUMBERG', 18)}}的其他基金

Aging and Emotion Regulation Brain Circuitry in Bipolar Disorder
双相情感障碍中的衰老和情绪调节大脑回路
  • 批准号:
    9320071
  • 财政年份:
    2017
  • 资助金额:
    $ 24.11万
  • 项目类别:
Aging and Emotion Regulation Brain Circuitry in Bipolar Disorder
双相情感障碍中的衰老和情绪调节大脑回路
  • 批准号:
    9908465
  • 财政年份:
    2017
  • 资助金额:
    $ 24.11万
  • 项目类别:
Ultra High Field Strength MRI and MRS Study of Bipolar Disorder in Adolescents
青少年双相情感障碍的超高场强 MRI 和 MRS 研究
  • 批准号:
    9341381
  • 财政年份:
    2016
  • 资助金额:
    $ 24.11万
  • 项目类别:
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
青春期的压力、神经发育和成瘾行为的出现
  • 批准号:
    8641261
  • 财政年份:
    2013
  • 资助金额:
    $ 24.11万
  • 项目类别:
Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
青少年自杀风险的生物标志物:影响因素
  • 批准号:
    7818648
  • 财政年份:
    2009
  • 资助金额:
    $ 24.11万
  • 项目类别:
Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
青少年自杀风险的生物标志物:影响因素
  • 批准号:
    7939638
  • 财政年份:
    2009
  • 资助金额:
    $ 24.11万
  • 项目类别:
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
青春期的压力、神经发育和成瘾行为的出现
  • 批准号:
    7498500
  • 财政年份:
    2007
  • 资助金额:
    $ 24.11万
  • 项目类别:
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
青春期的压力、神经发育和成瘾行为的出现
  • 批准号:
    7861013
  • 财政年份:
    2007
  • 资助金额:
    $ 24.11万
  • 项目类别:
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
青春期的压力、神经发育和成瘾行为的出现
  • 批准号:
    7466321
  • 财政年份:
    2007
  • 资助金额:
    $ 24.11万
  • 项目类别:
Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence
青春期的压力、神经发育和成瘾行为的出现
  • 批准号:
    8104231
  • 财政年份:
    2007
  • 资助金额:
    $ 24.11万
  • 项目类别:

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Neuronal regulation of glutamate homeostasis in addictive behavior
成瘾行为中谷氨酸稳态的神经元调节
  • 批准号:
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  • 批准号:
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Beta-arrestin Regulation of Ghrelin Signaling in Modulating Addictive Behavior
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  • 批准号:
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