Stress, Neurodevelopment and the Emergence of Addictive Behaviors in Adolescence

青春期的压力、神经发育和成瘾行为的出现

• 批准号: 7498500
• 负责人: HILARY Patricia BLUMBERG
• 金额: $ 24.35万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498500
• 关键词: Accidents; Addictive Behavior; Adolescence; Adolescent; Adolescent Medicine; Adult; Age; Alcohol consumption; Amygdaloid structure; Attention; Behavior; Behavior Control; Behavioral; Biogenic Amines; Biological; Biological Factors; Biology; Birth; Brain; Cause of Death; Child; Child Abuse and Neglect; Childhood; Cognition; Collaborations; Data; Development; Diffusion Magnetic Resonance Imaging; Discipline; Disease; Disruption; Early Intervention; Eating; Emotional; Face; Functional Magnetic Resonance Imaging; Functional disorder; Future; Genes; Genetic; Genetic Variation; Genotype; Hyperphagia; Image; Image Analysis; Impulsivity; Intervention; Laboratories; Link; Literature; Magnetic Resonance Imaging; Measures; Medical; Mental disorders; Metabolic; Methods; Modality; Modeling; Morbidity - disease rate; Multimodal Imaging; Neurobiology; Neurophysiology - biologic function; Neuropsychology; Neurosecretory Systems; Pediatrics; Pharmacology; Physiological; Prefrontal Cortex; Prevention; Principal Investigator; Process; Psychiatry; Psychology; Psychopathology; Psychosocial Assessment and Care; Psychosocial Factor; Range; Recording of previous events; Recruitment Activity; Regulation; Research; Research Personnel; Risk; Risk Factors; Sampling; Smoke; Smoking; Social Behavior; Statistically Significant; Stimulus; Stress; Suicide; Support System; System; Teenagers; Temperament; Testing; Variant; Ventral Striatum; Violence; Women' s Health; addiction; age group; alcohol misuse; base; biological adaptation to stress; biopsychosocial; cognitive control; cohort; critical developmental period; driving behavior; emotional stimulus; environmental stressor; experience; gene interaction; girls; hedonic; human subject; innovation; maltreatment; model development; mortality; motivated behavior; neural circuit; neurodevelopment; neuroimaging; novel; prenatal; promoter; relating to nervous system; response; serotonin transporter; stressor; white matter

Stress, Neurodevelppment and the Emergence of Addictive Behaviors in Adolescence (Project 6 of 14): Adolescence is a critical period for the emergence of addictive behaviors that not only place adolescents at immediate risk for morbidity and for accidents, suicide, and violent behavior (the leading causes of death in this age group), but also contribute to lifelong increases in major medical morbidity and early mortality. Though childhood stress is known to be a major risk factor for the development of addictive behaviors in adolescence, there is a paucity of study of the mechanisms by which stress leads to the emergence of addictive behaviors in teens. Our pilot data suggest that childhood stress alters development of ventral prefrontal cortex (VPFC) control over amygdala and ventral striatum responses to emotional stimuli, resulting in excessive drive towards hedonic stimuli, impulsivity and addictive behaviors. This project establishes a new collaboration between co-Pis Drs. Blumberg and Mayes to bring together their respective expertise in multimodality magnetic resonance imaging (MRI) study of adolescent brain development and modeling the influences of psychosocial factors on the development of adaptive emotional and social behaviors in children and adolescents. This will provide unique opportunities to study how psychosocial stressors in childhood alter cortico-limbic development to contribute to the emergence of addictive behaviors in adolescence. This study team will include Drs. Kalmar, Mazure, Nicholls, Nolen-Hoeksema, Ryan, Wang and other consortium collaborators to integrate perspectives including Adolescent Medicine, Neurobiology, Neuroimaging, Neuropsychology, Pediatrics, Psychiatry, Psychology and Women's Health. Dr. Mayes has followed a unique cohort prospectively since birth, now entering adolescence, carefully characterized with biannual assessments for biopsychosocial factors. We plan to study 70 adolescents from this cohort, ages 14-17 years (50% girls): 35 with a history of childhood maltreatment and 35 without a history of maltreatment. Dr. Blumberg's group will perform functional MRI and diffusion tensor imaging to examine regional brain response to emotional stimuli within cortico-limbic circuitry, the functional connectivity between components within this circuitry, as well as the integrity of the structural white matter connections in the circuitry. Consortium core (Projects 13,14) measures of stress, biological factors and addictive behaviors will provide rich opportunities for study, including interactions between stress and genetic variations associated with biogenic amine regulation of the amygdala-ventral striatum-VPFC neural system (as in 2,3,7,8) in influencing the emergence of addictive behaviors. Collaboration with Drs. Potenza and Neumeister (7,8) will provide opportunities to examine similarities and differences between adolescents and adults, and novel treatments tested (5,9,10) will provide the basis for future innovative prevention and early intervention strategies.

青春期压力、神经发育和成瘾行为的出现(项目6/14)： 青春期是成瘾行为出现的关键时期，成瘾行为不仅使青少年处于 发病、事故、自杀和暴力行为的直接风险(#年的主要死亡原因 这个年龄段)，但也促成了重大医疗发病率和早期死亡率的终生增加。 尽管童年压力被认为是儿童成瘾行为发展的主要危险因素 在青春期，缺乏对压力导致精神障碍出现的机制的研究 青少年的成瘾行为。我们的初步数据表明，童年压力改变了腹侧的发育 前额叶皮质(VPFC)控制杏仁核和腹侧纹状体对情绪刺激的反应，结果 过度追求享乐刺激、冲动和上瘾行为。这个项目建立了一个 共同Pis博士Blumberg和Mayes之间的新合作将把他们各自的专业知识结合在一起 青春期脑发育的多模式磁共振成像研究及模型建立 心理社会因素对儿童适应性情绪和社会行为发展的影响 和青少年。这将提供独特的机会来研究儿童时期的心理社会压力源 改变皮质-边缘发育导致青春期成瘾行为的出现。这 研究小组将包括卡尔马博士、马祖尔博士、尼科尔斯博士、诺伦-胡克塞马博士、瑞安博士、王博士和其他财团 合作者将整合青少年医学、神经生物学、神经成像、 神经心理学、儿科学、精神病学、心理学和妇女健康。梅耶斯博士遵循了一种独特的 队列前瞻性从出生开始，现在进入青春期，仔细地描述了两年一次的特点 生物、心理、社会因素的评估。我们计划研究这一队列中的70名青少年，年龄在14-17岁之间 年龄(50%女孩)：35人有儿童期虐待史，35人无虐待史。Dr。 Blumberg的团队将进行功能磁共振成像和扩散张量成像，以检查局部大脑 大脑皮质-边缘回路中对情绪刺激的反应，即各组成部分之间的功能连接 以及该电路中结构白质连接的完整性。 联合体核心(项目13、14)将提供压力、生物因素和成瘾行为的措施 丰富的研究机会，包括压力与基因变异之间的相互作用 生物胺对杏仁核-纹状体腹侧-VPFC神经系统(如2、3、7、8)的影响 成瘾行为的出现。与Potenza博士和Neumeister(7，8)博士的合作将提供 研究青少年和成人之间的异同以及新的治疗方法的机会 测试(5，9，10)将为未来创新的预防和早期干预战略提供基础。