UCSC Center for Genomic Science and Minority Outreach Program

UCSC 基因组科学中心和少数族裔外展计划

• 批准号: 7921323
• 负责人: DAVID H HAUSSLER
• 金额: $ 69万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921323
• 关键词: Address; Aging; Applications Grants; Architecture; Archives; Area; Biomedical Research; Communities; Confidentiality; Data; Data Quality; Data Set; Data Storage and Retrieval; Databases; Disease; Documentation; Feasibility Studies; Floods; Galaxy; Genbank; Genome; Genomics; Goals; Human; Imagery; Individual; Internet; Invertebrates; Large-Scale Sequencing; Link; Malignant Neoplasms; Maps; Medical; Methods; Minority Outreach Program; Mission; Modeling; Online Systems; Participant; Performance; Privacy; Process; Publications; Quality Control; Research; Research Personnel; Resources; Running; Science; Scientist; Secure; Sequence Alignment; Services; Site; Solutions; Somatic Cell; System; Time; Tissues; Training; Travel; Variant; Weight; Work; base; biomedical resource; biomedical scientist; comparative; firewall; flexibility; improved; indexing; next generation; prototype; tool

The UCSC Genome Browser (genome.ucsc.edu) is a vital resource for the biomedical community, providing timely, convenient access to sequence and annotations for the human and all other vertebrate reference species genomes, along with selected model invertebrates. However, the enormous capacity of next-generation sequencing platforms is rapidly outstripping all of the resources we can provide. Additionally, biomedical datasets are increasingly deemed to potentially contain identifying data, which raises substantial privacy protection issues. In this proposal, we outline a project to expand the Genome Browser architecture to address these growing data volume and privacy requirements. Our preliminary studies indicate that cloud computing and a web services model (such as is supported by Amazon) may provide a good solution to our data storage requirements and offer a high-performance solution for mapping, visualizing, and analyzing next-generation sequencing data, as well as providing a personalized browsing solution for biomedical research scientists who require an individual instance of the Genome Browser for confidentiality or configurability reasons, but wish to avoid the overhead of installing a local mirror of our browser. Through this project we plan to complete a feasibility study of the cloud computing solution and investigate (and potentially prototype) a web services architecture for the Genome Browser. We will also streamline the Genome Browser mirror site installation package for those labs that still require a local copy of the browser. Through this work, we will enhance biomedical research through an enhanced Genome Browser toolset that provides high-performance access to large datasets and controlled access for the visualization and analysis of confidential datasets.

UCSC基因组浏览器（www.example.com）是生物医学的重要资源。 社区，提供及时，方便地访问序列和注释， 人类和所有其它脊椎动物参考物种基因组，沿着选择的 无脊椎动物模型然而，下一代的巨大容量 测序平台正在迅速超过我们所能提供的所有资源。 此外，生物医学数据集越来越多地被认为可能包含 识别数据，这引起了实质性的隐私保护问题。在这项提案中， 我们概述了一个项目，以扩大基因组浏览器架构，以解决这些问题 不断增长的数据量和隐私要求。 我们的初步研究表明，云计算和Web服务模型 (such Amazon支持）可以为我们的数据存储提供很好的解决方案 要求，并提供高性能的解决方案，用于映射、可视化和 分析下一代测序数据，以及提供个性化的 浏览解决方案的生物医学研究科学家谁需要个人 出于保密性或可配置性原因， 希望避免安装本地浏览器镜像的开销。通过这个 项目我们计划完成云计算解决方案的可行性研究， 研究（并可能原型化）Genome的Web服务架构 浏览器.我们还将简化基因组浏览器镜像网站的安装 对于那些仍然需要浏览器的本地副本的实验， 通过这项工作，我们将加强生物医学研究， Genome Browser工具集，提供对大型数据集的高性能访问 和受控访问，用于机密数据集的可视化和分析。