EXPERIMENTAL TISSUE SHARED RESOURCE

实验组织共享资源(ETR)的主要目标是提供基本的、翻译的、 癌症中心的临床研究人员获取并分析人类和动物组织。一个 主要优势是，这一核心利用了新闻部的技术和专业知识 病理学与检验医学。目前提供三项服务：i)组织学和 免疫组织化学；ii)组织库；以及iii)组织分析，包括激光捕获显微镜， 形态测量和图像量化以及基因分型服务。因为核心是在上一次 资助期内，已有63家CFCCC会员使用过。在使用方面有所增长，特别是在 组织学/免疫组织化学成分，在ETR中占主要用途。在 在之前的资助期间，组织学部分以低于市场充值的价格提供了高质量的服务 费率，向52个主要追求翻译的不同CFCCC成员提供较短的周转时间 研究人类癌症标本或研究人类癌症的啮齿动物模型。当需要时，我们 提供个性化服务，满足会员的特殊需求。这些功能使我们的 组织学服务优于商业供应商提供的服务，有助于增加使用量。ETR 在上一个供资期间，服务部门为43份出版物提供了捐助，其中36份使用了组织学服务。 21名CFCCC调查人员使用了组织库服务。分析服务，由15人使用 研究人员，对于从事翻译和临床研究的研究人员来说尤其有价值 项目。在这次更新中，我们建议扩大规模，以满足对组织学服务日益增长的需求， 维持我们的专业分析服务，加强我们的组织采购活动，专注于 全面处理前列腺癌，并提供新的小鼠病理服务，将有助于 CFCCC研究人员在人类基因工程小鼠模型的初步表征中 癌症。

The primary objective of the Experimental Tissue Shared Resource (ETR) is to provide basic, translational, and clinical researchers within the Cancer Center access to, and analysis of, human and animal tissues. A key advantage is that this Core leverages the technical and professional expertise of the Department of Pathology and Laboratory Medicine. Three services are currently offered: i) tissue histology and immunohistochemistry; ii) tissue banking; and iii) tissue analysis, including laser capture microscopy, morphometry and image quantitation and genotyping services. Since the Core was initiated in the prior funding period, 63 CFCCC Members have used it. There has been growth in use, especially in the histology/immunohistochemistry component, which accounts for the majority of usage within the ETR. In the prior funding period, the histology component has provided high-quality service at below-market recharge rates, with short turn-around times to 52 different CFCCC Members who are mainly pursuing translational research on human cancer specimens or studying rodent models of human cancer. When required, we customized services to meet the special needs of CFCCC Members. These features have made our histology services superior to those available from commercial vendors, contributing to usage growth. ETR services contributed to 43 publications in the prior funding period, including 36 using histology services. Tissue banking services were used by 21 CFCCC investigators. Analytical services, used by 15 investigators, have been particularly valuable to investigators pursuing translational and clinical research projects. In this renewal, we propose to expand to meet an increased demand for histology services, maintain our specialty analytical services, strengthen our tissue procurement activities by focusing on comprehensively banking prostate cancers and provide a new mouse pathology service which will assist CFCCC investigators in the initial characterization of genetically engineered mouse models of human cancer.