Functional Anatomy of Visuomotor Learning & Motor Memory

视觉运动学习的功能解剖

• 批准号: 7795740
• 负责人: JOHN WALTER KRAKAUER
• 金额: $ 5.84万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795740
• 关键词: Anatomy; Area; Behavioral; Brain; Brain region; Cognition; Cognitive; Contralateral; Ensure; Event; Failure; Fingers; Focal Brain Injuries; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Goals; Hand; Head Movements; Image Analysis; Ipsilateral; Lead; Learning; Left; Linear Models; Location; Magnetic Resonance Imaging; Maps; Mediating; Memory; Methods; Modeling; Motor; Movement; Muscle; Patients; Pattern; Performance; Process; Psychological Transfer; Psychophysiology; Recovery; Research Personnel; Rotation; Series; Speed; Task Performances; Testing; Time; Visual; Weight; Wrist; arm; base; improved; insight; kinematics; motor learning; motor skill learning; neural patterning; novel; prevent; programs; relating to nervous system; skill acquisition; skills; visual motor

DESCRIPTION (provided by applicant): It is well known that most movements improve with practice. However, the way the brain accomplishes this remains largely unknown. Functional magnetic resonance imaging (fMRI) has provided significant insights into brain mechanisms of cognition. In comparison, fMRI studies of motor learning and motor memory have been limited by the constrained space and the problem of unwanted head movements. As a result the great majority of fMRI studies of motor learning have investigated sequences of finger movements. To overcome these limitations, we have developed a novel MR-compatible wrist task to study two types of motor learning that undrlie our ability to accurately point to visual targets: (1) Motor skill learning - the ability to acquire new patterns of muscle activity so that movement accuracy increases without a reduction in speed. (2) Visuomotor adaptation - the ability to associate an already learned pattern of muscle activation with a new spatial goal. We will study these two types of learning with a baseline and a rotation condition, respectively. In the baseline condition, subjects make fast uncorrected pointing movements of the wrist to a series of 8 targets arrayed on a screen. Skill is the decrease in movement time (MT) and endpoint variability with practice. In the rotation condition, with the same target set, subjects initially make systematic 30¿ directional errors, which they reduce through adaptation. Importantly, we have developed a method that keeps MT and peak velocity constant so that any observed brain activation changes are attributable to learning and not performance changes. In addition, we will also examine the neural correlates of re-learning on a second day, differences between the dominant and non-dominant hand, mechanisms of motor interference, and degree of transfer of motor learning between arms. A better understanding of hemispheric contributions to motor learning and motor memory will offer insight into mechanisms of recovery after focal brain injury. We anticipate our approach will be applicable to patients in future studies.

描述（由申请人提供）：众所周知，大多数动作都会通过练习而提高。然而，大脑实现这一点的方式仍然很大程度上未知。功能磁共振成像（fMRI）为大脑认知机制提供了重要的见解。相比之下，运动学习和运动记忆的功能磁共振成像研究受到空间有限和不必要的头部运动问题的限制。因此，绝大多数运动学习的功能磁共振成像研究都研究了手指运动的序列。为了克服这些限制，我们开发了一种新颖的 MR 兼容手腕任务来研究两种类型的运动学习，这些运动学习增强了我们准确指向视觉目标的能力：（1）运动技能学习 - 获得新的肌肉活动模式的能力，从而在不降低速度的情况下提高运动准确性。 (2) 视觉运动适应——将已经学习的肌肉激活模式与新的空间目标联系起来的能力。我们将分别在基线和旋转条件下研究这两种类型的学习。在基线条件下，受试者对屏幕上排列的一系列 8 个目标进行快速且未经校正的手腕指向运动。技能是指随着练习运动时间 (MT) 和终点变异性的减少。在旋转条件下，具有相同的目标集，受试者最初会产生系统性的 30° 方向误差，他们通过适应来减少这些误差。重要的是，我们开发了一种保持 MT 和峰值速度恒定的方法，这样任何观察到的大脑激活变化都可以归因于学习而不是表现变化。此外，我们还将检查第二天重新学习的神经相关性、优势手和非优势手之间的差异、运动干扰机制以及手臂之间运动学习的转移程度。更好地了解半球对运动学习和运动记忆的贡献将有助于深入了解局灶性脑损伤后的恢复机制。我们预计我们的方法将适用于未来研究中的患者。