Novel Algorithms and Device for Quantification of Wake-Sleep States

描述（由申请人提供）：本项目的总体目标是开发一种方法（硬件、算法、电极附件），从根本上改进长期监测睡眠结构和质量以及白天嗜睡的方法。本项目将开发的设备（称为“神经监测仪”）将用于评估睡眠障碍和日间嗜睡，特别强调原发性失眠的诊断和管理。慢性失眠影响10-15%的成年人（非机构老年人的患病率为57%），另外25 - 35%的成年人有短暂或偶尔的失眠。不稳定与重大的个人和社会经济负担相关，并且在很大程度上被低估，治疗不充分或不适当（包括过度用药）。该项目的具体目标是将Neurobiology开发为可穿戴的（并且易于由患者部署）、全自动和（高度）定量的脑电波和唤醒-睡眠阶段分析仪，用于延长夜间睡眠和白天嗜睡，并用于患者的正常家庭环境。Neurosurgery将利用第一阶段开发的量化清醒-睡眠转换的新算法。该设备将在正常受试者和失眠患者中进行广泛的临床评估和验证。这种创新的设备将有可能显着改善失眠症状的睡眠障碍的管理，以及一些经常与失眠有关的精神疾病，特别是抑郁症。公共卫生相关性：将在本项目中开发的设备（“神经监测仪”）将用于评估睡眠障碍和白天嗜睡，特别强调原发性失眠的诊断和管理。神经监测仪将被开发为一种可穿戴的（并且易于患者部署），全自动和（高度）定量的脑电波和唤醒睡眠阶段分析仪，用于延长夜间睡眠和白天嗜睡，并用于患者的正常家庭环境。这种创新的设备将有可能显着改善失眠症状的睡眠障碍的管理，以及一些经常与失眠有关的精神疾病，特别是抑郁症。

DESCRIPTION (provided by applicant): The overall goal of this project is to develop the means (hardware, algorithm, electrode attachments) for a fundamentally improved method for long-term monitoring of sleep architecture and quality, as well as daytime sleepiness. The device that will be developed in this project, (referred to as NeuroLOG"), will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. Chronic insomnia affects 10-15% of adults (with a prevalence of 57% in non-institutionalized elderly persons), and an additional 25 to 35 percent of adults have transient or occasional insomnia. Insomnia is associated with significant personal and socioeconomic burden, and is largely under- recognized and inadequately or inappropriately treated (including overmedication). The specific aim of the project is to develop NeuroLOG as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night- time sleep, and daytime sleepiness, and for use in the patients' normal home environment. NeuroLOG will take advantage of the novel algorithms for quantifying wake-sleep transitions that was developed in Phase I. The device will undergo extensive clinical evaluation and validation with normal subjects as well as patients with insomnia. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression. PUBLIC HEALTH RELEVANCE: The device that will be developed in this project (NeuroLOG") will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. NeuroLOG will be developed as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night-time sleep, and daytime sleepiness, and for use in the patients' normal home environment. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression.