Lysophosphatidylcholine Isoforms as Clinical Markers of Colorectal Cancer and Pol

溶血磷脂酰胆碱亚型作为结直肠癌和 Pol 的临床标志物

• 批准号: 7687117
• 负责人: WON KYOO CHO
• 金额: --
• 依托单位: RLR VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687117
• 关键词: 3 year old; Adenomatous Polyps; Adherence; Affect; African American; Aging; Alcohol consumption; Biochemical; Biological Markers; Blood specimen; Cancer Etiology; Cancer Patient; Cancerous; Carcinoma; Caring; Cell physiology; Cessation of life; Clinic; Clinical Markers; Colon; Colonic Adenoma; Colonic Polyps; Colonoscopy; Colorectal; Colorectal Cancer; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Diet; Disease; Early Diagnosis; Elderly; Evaluation; Family history of; Fasting; Female; Gender; Goals; Healthcare; Incidence; Indiana; Inflammatory Bowel Diseases; Lesion; Link; Lipids; Lysophosphatidylcholines; Malignant - descriptor; Malignant Neoplasms; Medical; Medical center; Minority; Molecular; Operative Surgical Procedures; Patients; Pilot Projects; Plasma; Polyps; Population; Population Study; Premalignant; Preparation; Protein Isoforms; Race; Recording of previous events; Reporting; Reproducibility; Research; Risk Factors; Role; Sampling; Second Primary Cancers; Sensitivity and Specificity; Smoking; Staging; Survival Rate; Test Result; Testing; Time; United States; United States Department of Veterans Affairs; Universities; Veterans; Visit; Work; abstracting; adenoma; cancer diagnosis; cancer risk; case control; clinically significant; colorectal cancer screening; cost; demographics; follow-up; improved; male; minimally invasive; new therapeutic target; patient population; prognostic; public health relevance; tool

DESCRIPTION (provided by applicant): Project Summary/Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the United States. Since early detection of CRC is associated with excellent survival rates, development of non- invasive and highly reliable test for CRC is greatly needed for veterans. While colonoscopy has reported sensitivity and specificity values exceeding 95%, the degree of adherence is low due to the cost, as well as to perceived inconvenience and discomfort associated with this test. As a result, many patients still present with late-stage and potentially fatal disease. We have found that plasma levels of several lipids, called lysophosphatidylcholines (LPCs), are potential markers for CRC and our pilot work show that these markers achieved a sensitivity and specificity of 82% and 93%, respectively for CRC. It is critical and absolutely necessary to establish reproducibility and to retest and validate the estimates for sensitivity and specificity in completely independent VA population sets in order to critically evaluate the clinical significance and utility of these markers to be useful for veterans. We propose 2 aims. First, we will critically evaluate whether plasma LPC levels are effective markers for detecting CRC by determining their sensitivity and specificity in VA patient population, a totally independent study population. Secondly, we will determine whether plasma LPC levels are effective markers for pre-cancerous adenomatous colon polyps. Our long-term goals are 1) to develop highly sensitive and reliable diagnostic and prognostic, non- or minimally invasive biomarkers for improving early detection, management and follow up of CRC patient samples obtained and 2) to develop biomarkers to detect pre-cancerous adenomatous colon polyps. Potential Impact on Veterans Health Care: More veterans are diagnosed and/or treated for colorectal cancer in the Veteran Administration (VA) and such CRC incidence rate will increase with aging VA population. The proposed research will provide an important diagnostic non-invasive tool for veterans to improve early detection of CRC and colon polyp thus optimize CRC medical care for VA population. PUBLIC HEALTH RELEVANCE: Potential Impact on Veterans Health Care: More veterans are diagnosed and/or treated for colorectal cancer in the Veteran Administration (VA) and such CRC incidence rate will increase with aging VA population. The proposed research will provide an important diagnostic non-invasive tool for veterans to improve early detection of CRC and colon polyp thus optimize CRC medical care for VA population.

描述（由申请人提供）： 结直肠癌（CRC）是美国第三大最常见的癌症，也是癌症相关死亡的第二大原因。由于CRC的早期发现与良好的生存率相关，因此退伍军人非常需要开发非侵入性和高度可靠的CRC测试。虽然结肠镜检查报告的灵敏度和特异性值超过95%，但由于成本以及与该测试相关的感知不便和不适，依从性程度较低。因此，许多患者仍然存在晚期和潜在致命的疾病。我们发现，血浆中几种脂质（称为溶血磷脂酰胆碱（LPC））的水平是CRC的潜在标志物，我们的初步工作表明，这些标志物对CRC的敏感性和特异性分别为82%和93%。这是至关重要的，绝对必要的，以建立可重复性和重新测试和验证的估计灵敏度和特异性在完全独立的VA人口集，以严格评估这些标志物的临床意义和效用是有用的退伍军人。我们提出两个目标。首先，我们将严格评估血浆LPC水平是否是检测CRC的有效标志物，通过确定其在VA患者人群（一个完全独立的研究人群）中的灵敏度和特异性。其次，我们将确定血浆LPC水平是否是癌前腺瘤性结肠息肉的有效标志物。我们的长期目标是1）开发高度敏感和可靠的诊断和预后，非侵入性或微创生物标志物，用于改善所获得的CRC患者样本的早期检测，管理和随访，以及2）开发生物标志物以检测癌前腺瘤性结肠息肉。对退伍军人医疗保健的潜在影响：更多的退伍军人在退伍军人管理局（VA）被诊断和/或治疗结直肠癌，这种CRC发病率将随着VA人口的老龄化而增加。拟议的研究将为退伍军人提供一个重要的非侵入性诊断工具，以提高CRC和结肠息肉的早期检测，从而优化VA人群的CRC医疗护理。 公共卫生相关性： 对退伍军人医疗保健的潜在影响：更多的退伍军人在退伍军人管理局（VA）被诊断和/或治疗结直肠癌，这种CRC发病率将随着VA人口的老龄化而增加。拟议的研究将为退伍军人提供一个重要的非侵入性诊断工具，以提高CRC和结肠息肉的早期检测，从而优化VA人群的CRC医疗护理。