Determinants and Correlates of Physical Activity in Breast Cancer Survivors

乳腺癌幸存者身体活动的决定因素和相关性

• 批准号: 7798689
• 负责人: Siobhan Marie Phillips
• 金额: $ 3.56万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7798689
• 关键词: Accounting; Adjuvant Therapy; Adopted; Adverse effects; American Cancer Society; Behavior; Behavioral; Cancer Survivor; Cessation of life; Cognitive; Comorbidity; Coping Skills; Coupled; Diagnosis; Disease; Distress; Elements; General Population; Goals; Guidelines; Health Care Costs; Health Status; Health Status Indicators; Health behavior; Individual; Literature; Measures; Mental Health; Modeling; Outcome; Paper; Pathway interactions; Performance; Physical activity; Population; Public Health; Quality of life; Recommendation; Reporting; Research; Risk; Self Efficacy; Series; Specific qualifier value; Survival Rate; Testing; Theoretical model; Time; Translating; Woman; Work; anticancer research; breast cancer diagnosis; cancer prevention; cancer recurrence; design; effective intervention; expectation; experience; health related quality of life; improved; lifestyle factors; malignant breast neoplasm; meetings; premature; programs; prospective; psychosocial; social; social cognitive theory; sound; standard care

DESCRIPTION (provided by applicant): There are over 2.4 million breast cancer survivors (BCS) in the U.S. accounting for 22% of all cancer survivors [1]. The 5-year survival rate of 88.6% [1] coupled with a 1 in 8 lifetime chance of a breast cancer diagnosis [2] has resulted in an increasingly growing population with distinct public health needs resulting from side effects associated with current available treatments [3]. In addition, BCS are at an increased risk of cancer recurrence, comborbidites, premature death and decreased quality of life (QOL) [4-6]. Physical activity (PA) has been identified as a lifestyle factor with excellent potential for ameliorating the aversive side effects of treatment and positively influencing disease-related outcomes [7, 8]. However, only 1/3 of BCS meet the current public health guidelines for PA [9, 10]. Identifying factors influencing PA participation and how PA is related to QOL in BCS is important for developing effective interventions which can be translated into practice. This project will adopt a prospective design to test the full Social Cognitive Theory (SCT) model for explaining PA in BCS over the course of a 6-month period. Previous research has used individual elements of SCT to understand and predict PA behavior in the general population [11-13], but the full model has yet to be tested, particularly in BCS. The proposed study will include measures to test the full SCT: self-efficacy, goals, outcome expectations, sociocultural factors (facilitators and impediments), and PA behavior [14]. PA has also been shown to positively influence QOL in BCS [7, 8]. However, very little research has been conducted to explain this relationship. Thus, the proposed study will also include measures to test the PA and QOL model proposed by McAuley and colleagues [15] in BCS. This model proposes PA influences global QOL indirectly through its effects on self-efficacy and health related QOL (physical and mental health) whereby self-efficacy is both directly and indirectly related to global QOL through its effect on health related QOL. The public health significance of this study lies in its potential to develop an improved, theoretically sound understanding of PA behavior in BCS as well as a better understanding of the relationship between PA and QOL. These findings could potentially result in better designed, more effective PA programs for BCS which ultimately has the potential to reduce healthcare costs associated with cancer recurrence, comorbidities, and premature death in BCS.

描述（由申请人提供）：美国有超过240万乳腺癌幸存者（BCS），占所有癌症幸存者的22%[1]。88.6%的5年生存率[1]加上1/8的终身乳腺癌诊断机会[2]导致人口日益增长，由于与当前可用治疗相关的副作用而产生不同的公共卫生需求[3]。此外，BCS的癌症复发、合并症、过早死亡和生活质量（QOL）下降的风险增加[4-6]。 体力活动（PA）已被确定为一种生活方式因素，具有改善治疗不良副作用和积极影响疾病相关结局的良好潜力[7，8]。然而，只有1/3的BCS符合PA的现行公共卫生指南[9，10]。识别影响PA参与的因素以及PA与BCS中的QOL如何相关对于制定可以转化为实践的有效干预措施非常重要。 本研究将采用前瞻性的设计，在六个月的时间内测试社会认知理论（SCT）解释BCS中PA的完整模型。以前的研究已经使用SCT的单个元素来理解和预测一般人群中的PA行为[11-13]，但完整的模型尚未得到测试，特别是在BCS中。拟议的研究将包括测试完整SCT的措施：自我效能，目标，结果预期，社会文化因素（促进者和障碍）和PA行为[14]。 PA也被证明对BCS的QOL有积极影响[7，8]。然而，很少有研究来解释这种关系。因此，拟议的研究还将包括测试McAuley及其同事[15]在BCS中提出的PA和QOL模型的措施。该模型提出PA通过影响自我效能和健康相关QOL（身体和心理健康）间接影响整体QOL，其中自我效能通过影响健康相关QOL直接或间接影响整体QOL。 本研究的公共卫生意义在于它有可能发展一个改进的，理论上合理的理解，在BCS的PA行为，以及更好地了解PA和生活质量之间的关系。这些发现可能会导致更好的设计，更有效的PA计划，最终有可能降低与BCS癌症复发，合并症和过早死亡相关的医疗费用。