Optimising efficacy of a peptide derived against the alpha-interacting domain of the L-type calcium channel in reduction of ischemia-reperfusion injury

优化 L 型钙通道 α 相互作用结构域衍生肽在减少缺血再灌注损伤中的功效

• 批准号: nhmrc : 1043978
• 负责人: A/Pr Ben Corry
• 金额: $ 27.01万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-efficacy-peptide-reperfusion-injury/111619
• 关键词: Optimising; efficacy; peptide; derived; against

A heart attack is associated with an increase in free radicals and calcium in heart muscle cells. The function of the L-type calcium channel, a protein responsible for calcium entry into cells, is altered by free radicals and this contributes to the development of heart disease. We now have considerable proof of concept that a peptide derived against the L-type calcium channel can decrease heart injury. We will optimise efficacy and delivery of the peptide to prevent heart failure.

心脏病发作与心肌细胞中自由基和钙的增加有关。L型钙通道是一种负责钙进入细胞的蛋白质，其功能被自由基改变，这有助于心脏病的发展。我们现在有相当多的证据表明，一种针对L型钙通道的肽可以减少心脏损伤。我们将优化肽的功效和递送，以预防心力衰竭。