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A novel patch-fluorimetry technique for investigating structural changes during gating of mechanosensitive ion channnels

A novel patch-fluorimetry technique for investigating structural changes during gating of mechanosensitive ion channnels
一种新型贴片荧光测定技术,用于研究机械敏感离子通道门控过程中的结构变化
批准号:
nhmrc : 635525
负责人:
A/Pr Ben Corry
金额:
$25.81万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
Membrane proteins, especially membrane channels play an important role in regulating the flow of substances across the cell. Dysfunction in these channels can lead to a variety of diseases. Thus approximately 60% of drug development is targeted against such proteins. In our research, we are looking at membrane channels found in bacteria. Understanding the function of these channels will help us develop novel anti-bacterial agents. It will also aid to understand a role of ion channels in disease.
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Investigation of lipid-protein interactions of mechanosensitive ion channels
Optimising efficacy of a peptide derived against the alpha-interacting domain of the L-type calcium channel in reduction of ischemia-reperfusion injury
  • 批准号:
    nhmrc : 1043978
  • 项目类别:
    Project Grants
  • 资助金额:
    $27.01万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Ben Corry
  • 依托单位:
Identifying the site/s of modification on the human L-type Ca2+ channel protein isoforms during oxidative stress with reference to development of a therapeutic target
  • 批准号:
    nhmrc : 1010726
  • 项目类别:
    Project Grants
  • 资助金额:
    $24.03万
  • 财政年份:
    2011
  • 负责人:
    A/Pr Ben Corry
  • 依托单位:
The role of glutathionylation in redox modification of L-type Ca2+ channel function during oxidative stress in the heart
  • 批准号:
    nhmrc : 513726
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $26.87万
  • 财政年份:
    2008
  • 负责人:
    A/Pr Ben Corry
  • 依托单位:
国内基金
海外基金
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  • 批准号:
    82372148
  • 项目类别:
    面上项目
  • 资助金额:
    60.00万元
  • 批准年份:
    2023
  • 负责人:
    黄琳
  • 依托单位:
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  • 批准号:
    82201231
  • 项目类别:
    青年科学基金项目(C类)
  • 资助金额:
    20.0万元
  • 批准年份:
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  • 负责人:
    韦佳如
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SUGP2基因及其突变在遗传性血色病中的致病作用及其机制研究
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    2019
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基于Patch-seq从单细胞水平分析中脑-边缘多巴胺亚群神经元的分子特性及其与MA成瘾的关系
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    81871044
  • 项目类别:
    面上项目
  • 资助金额:
    56.0万元
  • 批准年份:
    2018
  • 负责人:
    孙晋浩
  • 依托单位: