A novel patch-fluorimetry technique for investigating structural changes during gating of mechanosensitive ion channnels

一种新型贴片荧光测定技术，用于研究机械敏感离子通道门控过程中的结构变化

• 批准号: nhmrc : 635525
• 负责人: A/Pr Ben Corry
• 金额: $ 25.81万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-patch-fluorimetry-ion-channnels/98331
• 关键词: novel; patch; fluorimetry; technique; investigating

Membrane proteins, especially membrane channels play an important role in regulating the flow of substances across the cell. Dysfunction in these channels can lead to a variety of diseases. Thus approximately 60% of drug development is targeted against such proteins. In our research, we are looking at membrane channels found in bacteria. Understanding the function of these channels will help us develop novel anti-bacterial agents. It will also aid to understand a role of ion channels in disease.

膜蛋白，特别是膜通道在调节物质在细胞中的流动中起着重要作用。这些通道的功能障碍可能导致各种疾病。因此，大约60%的药物开发是针对这些蛋白质的。在我们的研究中，我们正在研究细菌中发现的膜通道。了解这些通道的功能将有助于我们开发新的抗菌剂。它也将有助于了解离子通道在疾病中的作用。