Identifying the site/s of modification on the human L-type Ca2+ channel protein isoforms during oxidative stress with reference to development of a therapeutic target

参考治疗靶点的开发，确定氧化应激过程中人 L 型 Ca2 通道蛋白异构体的修饰位点

• 批准号: nhmrc : 1010726
• 负责人: A/Pr Ben Corry
• 金额: $ 24.03万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-sites-modification-therapeutic-target/109520
• 关键词: Identifying; site; modification; human; type

A rise in calcium and free radicals in the heart are associated with the development of heart disease. We have good evidence that a protein in the heart muscle known as the L-type calcium channel mediates changes in calcium in response to free radicals. This proposal will identify how the channel function is altered by free radicals so that a therapeutic target can be designed to prevent altered channel function and development of heart disease during increases in free radicals.

心脏中钙和自由基的增加与心脏病的发展有关。我们有充分的证据表明，心肌中一种被称为L型钙通道的蛋白质介导了钙对自由基的反应。该提案将确定通道功能如何被自由基改变，以便可以设计治疗靶点以防止在自由基增加期间改变通道功能和心脏病的发展。