The role of glutathionylation in redox modification of L-type Ca2+ channel function during oxidative stress in the heart

心脏氧化应激过程中谷胱甘肽化在 L 型 Ca2 通道功能氧化还原修饰中的作用

• 批准号: nhmrc : 513726
• 负责人: A/Pr Ben Corry
• 金额: $ 26.87万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-glutathionylation-redox-stress-heart/77369
• 关键词: role; glutathionylation; redox; modification; type

The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for regulating the entry of calcium into cells and maintaining normal heart rhythm and contraction. We have shown that reactive oxygen species can regulate the function of the calcium channel. We are now interested in determining whether a direct modification of the channel protein known as glutathionylation is responsible for altered channel function during oxidative stress such as after a heart attack.

l型钙通道是心肌细胞膜上的一种蛋白质，负责调节钙进入细胞并维持正常的心律和收缩。我们已经证明活性氧可以调节钙通道的功能。我们现在感兴趣的是确定在氧化应激（如心脏病发作后）过程中，通道蛋白被称为谷胱甘肽化的直接修饰是否导致了通道功能的改变。