Investigation of lipid-protein interactions of mechanosensitive ion channels

机械敏感离子通道的脂质-蛋白质相互作用的研究

• 批准号: nhmrc : 1047980
• 负责人: A/Pr Ben Corry
• 金额: $ 27.32万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-lipid-protein-ion-channels/111988
• 关键词: Investigation; lipid; protein; interactions; mechanosensitive

Living organisms are imminently exposed to mechanical stimuli such as gravity, touch or sound. Sensing mechanical stimuli is therefore crucial for survival. One biological tool for sensing mechanical stress are the mechanosensitive ion channels that open in response to tension in cell membranes. We will study the interactions and coupling between membrane lipids and mechanosensitive ion channels. These interactions are essential for the function of these fascinating sensory biological molecules.

活的有机体立即暴露于机械刺激，如重力，触摸或声音。因此，感知机械刺激对生存至关重要。用于感测机械应力的一种生物工具是响应于细胞膜中的张力而打开的机械敏感离子通道。我们将研究膜脂和机械敏感离子通道之间的相互作用和耦合。这些相互作用对于这些迷人的感官生物分子的功能至关重要。