MEIOTIC RECOMBINATION IN THE YEAST S CEREVISIAE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 以下摘要摘自Keeney Lab我们页面： 减数分裂重组是由拓扑异构酶样Spo 11蛋白产生的DNA双链断裂（DSB）启动的。本论文研究了Spo 11依赖性DSB在酵母S.酿酒酵母，以及检查的因素，决定Spo 11切割的DNA和控制重组过程的结果。"

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The following summary is taken from the Keeney Lab we page: "Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process."