MEIOTIC RECOMBINATION IN THE YEAST S CEREVISIAE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 以下摘要摘自Keeney Lab We页面： 减数分裂重组是由类似拓扑异构酶的Spo11蛋白产生的DNA双链断裂(DSB)启动的。我们正在研究酿酒酵母中依赖Spo11的DSB形成的机制和调节，以及研究决定Spo11在哪里切割DNA和控制重组过程结果的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The following summary is taken from the Keeney Lab we page: "Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process."