DNA BREAK REPAIR PROTEIN PHOSPHORYLATION

DNA 断裂修复蛋白磷酸化

• 批准号: 8361568
• 负责人: Scott Keeney
• 金额: $ 0.26万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361568
• 关键词: Coupled; DNA; DNA Repair Pathway; Funding; Grant; National Center for Research Resources; Phosphorylation; Phosphorylation Site; Post Translational Modification Analysis; Principal Investigator; Research; Research Infrastructure; Resources; Saccharomycetales; Source; United States National Institutes of Health; base; cost; macromolecule; repaired; yeast protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In budding yeast, the protein Rec104 is involved in the DNA repair pathway. Using immuno-isolation of endogenous rec104 coupled with MS-based analysis of post-translational modification we aim to determine what the sites of phosphorylation are on Rec104

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 在芽殖酵母中，蛋白质Rec 104参与DNA修复途径。 使用内源性rec 104的免疫分离结合基于MS的翻译后修饰分析，我们旨在确定Rec 104上的磷酸化位点