2008 Meiosis Gordon Research Conference

描述(由申请人提供)：2008年6月8日至13日，将在新伦敦的科尔比-索耶学院举行的戈登研究会议的一部分，请求部分支持一个关于减数分裂的国际会议。减数分裂是产生精子和卵子等生殖细胞的特殊细胞分裂。会议的长期目标是了解正常和疾病条件下减数分裂染色体分离和细胞分裂的基本机制。重点是染色体动力学，但实质上涵盖了细胞骨架和核结构、基因调控、配子发生和进化方面。会议的具体目的是为这一跨学科领域的科学互动提供一个论坛，介绍该领域的最新成果，向该领域介绍年轻的研究人员并促进他们与现有研究人员的互动，并促进跨学科讨论，以促进新的方法、概念和想法。会议将召集大约175名与会者，其中包括50名发言者，讨论尖端的、主要是未发表的研究。该计划包括9个全体会议，广泛讨论当前同源重组；减数分裂进程的调节；细胞周期检查点；组蛋白修饰和减数分裂基因表达的控制；转座元件的抑制；染色体配对和突触；姐妹染色单体凝聚；减数分裂花束和核膜；染色体分离；减数分裂和有性生殖的进化。四人会议将提供一个额外的论坛，对所有参与者开放。这项应用与健康相关的是，减数分裂中的错误至少导致了临床上公认的流产的一半，以及人类一系列染色体出生缺陷。这次会议提供了一个讨论论坛，将增进我们对生殖健康这一基本方面的理解，并将提出推动未来研究所需的实验问题。项目简介：卵子或精子中的染色体数目异常会导致发育障碍或自然流产。这些异常通常是由于减数分裂过程中染色体分离不当造成的，减数分裂是产生生殖细胞的细胞分裂。这次会议将提供一个讨论论坛，以增进对生殖健康的了解，并确定未来旨在了解正常减数分裂以及减数分裂细胞所犯错误的实验问题。

DESCRIPTION (provided by applicant): Partial support is requested for an international meeting on Meiosis as part of the Gordon Research Conferences, to be held at Colby-Sawyer College in New London, NH June 8-13, 2008. Meiosis is the specialized cell division that gives rise to reproductive cells such as sperm and eggs. The long-term goal of the conference is to understand the fundamental mechanisms of meiotic chromosome segregation and cell division in both normal and disease conditions. The emphasis is on chromosome dynamics, but with substantial coverage of cytoskeletal and nuclear structure, gene regulation, gametogenesis, and evolutionary aspects. The specific aims of the meeting are to provide a forum for scientific interaction in this interdisciplinary field, to present the newest results in the field, to introduce young researchers to the field and foster their interactions with established investigators, and to promote interdisciplinary discussion that will foster new approaches, concepts, and ideas. The meeting will convene approximately 175 participants, including 50 speakers, to discuss cutting-edge, mostly unpublished research. The program comprises 9 plenary sessions that broadly address current issues in homologous recombination; regulation of meiotic progression; cell cycle checkpoints; histone modifications and control of meiotic gene expression; suppression of transposable elements; chromosome pairing and synapsis; sister chromatid cohesion; the meiotic bouquet and the nuclear envelope; chromosome segregation; and the evolution of meiosis and sexual reproduction. Four poster sessions will provide an additional forum open to all participants. The health relatedness of this application is that errors in meiosis are responsible for at least half of clinically recognized miscarriages, as well as a spectrum of chromosomal birth defects in humans. This meeting provides a forum for discussions that will advance our understanding of this fundamental aspect of reproductive health and that will frame the experimental questions necessary to drive future research. Project Narrative: Abnormal chromosome numbers in eggs or sperm cause developmental disabilities or spontaneous abortion. These abnormalities often arise because of improper separation of chromosomes during meiosis, the cell division that generates the reproductive cells. This meeting will provide a forum for discussions that advance knowledge of reproductive health, and that define the future experimental questions aimed at understanding normal meiosis as well as the errors made by meiotic cells.