MOLECULAR BIOLOGY AND TISSUE ENGINEERING CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 分子生物学和组织工程(MBTE)核心设施 MBTE的核心设施包括两个部分，分子生物学(MB)和组织工程(TE)。核心设施是在药学与健康科学学院(COPHS)创建的，以支持生物医学研究活动。MBTE核心设施的目的是维护和加强现有的分子生物学和二维(2D)细胞培养组件(MB)；并开发和建立支持三维(3D)组织等效细胞培养技术的新的组织工程部分(TE)组件，为台大生物医学研究人员提供最先进的分子生物学和细胞培养研究基础设施。MBTE核心设施的具体目标是： 1.继续为台湾省调查人员提供分子生物学和二维细胞培养方面的技术和实践支持服务，以及必要的仪器设备。 2.增设组织工程(TE)科，建立复杂的三维组织等效体外模型系统，为有意将该技术应用于生物医学研究的台大教职员工和研究生提供技术支持服务。 3.透过研究发展活动、研讨会、期刊社会议、研究报告等，为台大科研人员营造激励与支持的科学氛围。 4.开展合作研究工作，与台大和其他研究密集型大学的研究人员交流技术能力；并参加技术讲习班。 在过去的一年里，MBTE核心设施通过技术和实际操作的研究支持服务，以及为TSU的研究调查人员提供的仪器，所开展的活动取得了重大成果。该机制共为26个项目提供了支助，其结果是：12份摘要报告；7份出版物；5份提案，其中1份待决，2份未获资助，2份正在准备重新提交。此外，MBTE设施为四名药学硕士/博士生提供了培训和研究资源支持。此外，MBTE核心主任和助理主任已经在TSU内外建立了十个合作伙伴(Rambis Chu、Mohammad Newaz、Kasturi Ranganna和Zivar Yousefiour博士)和TSU外(来自加州大学戴维斯分校的Frank M.Yatsu、加州大学戴维斯分校的Bruce Hammock和Christopher Morisseau博士，以及来自加州奥兰治县儿童医院的Philip Schwartz博士、加州大学欧文分校、匈牙利Basalingappa匈牙利分校、哥伦比亚大学，纽约和Betsy Southerland布鲁克海文国家实验室的Betsy Southerland博士)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Molecular Biology and Tissue Engineering (MBTE) Core Facility The MBTE core facility consists of two components, Molecular Biology (MB) and Tissue Engineering (TE). The core facility was created at the College of Pharmacy and Health Sciences (COPHS) to support biomedical research activities. The purpose of the MBTE core facility is to maintain and enhance the existing molecular biology and 2-dimensional (2-D) cell culture component (MB); and to develop and establish a new tissue engineering section (TE) component that supports 3-dimensional (3-D) tissue-equivalent cell culture technology to provide biomedical researchers at TSU with state-of-the-art molecular biology and cell culture research infrastructure. The specific aims of the MBTE core facility are to: 1. Continue to provide the technical and hands-on support services in molecular biology and 2- dimensional cell culture, and requisite instrumentation to TSU investigators. 2. Add a new tissue engineering (TE) section to establish a complex 3-D tissue-equivalent in vitro model system and provide technical support services to TSU faculty and graduate students interested in utilizing this technology in their biomedical research. 3. Create a stimulating and supportive scientific atmosphere for the researchers at TSU through research development activities, seminar programs, journal club meetings, and research presentations. 4. Establish collaborative research efforts, and pursue exchange of technical capabilities with investigators at TSU and other research-intensive universities; and by attending technology workshops. In the previous year, the activities of MBTE core facility, through the technical and hands-on research support services, and instrumentation to the research investigators at TSU have resulted in significant outcomes. The facility provided support for a total of 26 projects, which resulted in: 12 abstract presentations; 7 publications; and 5 proposals, of which one is pending, two are not funded and two are in preparation for resubmission. Additionally, the MBTE facility facilitated training and povided research resource support to four pharmaceutical sciencesis MS/PhD students. Furthermore, the MBTE core director and assistant director have established a total of ten collaborations within TSU (Drs. Rambis Chu, Mohammad Newaz, Kasturi Ranganna and Zivar Yousefipour) and outside TSU (Drs. Frank M. Yatsu, UT Health Science Center, Houston, Bruce Hammock, and Christopher Morisseau from University of California, Davis, CA, and Philip Schwartz, Children's Hospital of Orange County, University of California, Irvine, CA, Basalingappa Hungund, Columbia University, NY and Betsy Southerland, Brookhaven National Laboratory, Upton, NY.