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中文摘要
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描述(由申请人提供):通过将婴儿保持在由保温箱/加温器提供的受控温度环境中,新生儿存活率大大提高。为了准确地控制体温,必须对婴儿进行一致和可靠的体温测量。目前,这是使用温度传感器(热敏电阻)来实现的,该温度传感器通过粘合剂固定到身体上。这种方法的缺点是单点测量,并且粘合剂会损害婴儿的娇嫩皮肤。此外,传感器易于移位,导致反馈温度控制的问题。出于这些原因,我们建议开发和测试一种非接触式的温度传感方案的基础上的凝胶,具有温度敏感的分子在it. The建议的分子是荧光和它们的发光作为温度的函数而变化。通过这种方法,凝胶可以使用LED远端激发,并通过廉价的数码相机成像。先进传感器技术中心和通用电气医疗保健公司提出了一个R21项目,该项目将开发和测试用于非接触式温度传感的传感凝胶和仪器。该系统将在用猪皮包裹的充水玩偶上进行测试,以模仿新生儿。我们预计该系统将在两年项目结束时准备好进行动物和人体试验。 公共卫生相关性:非接触式温度传感器建议用于婴儿保育箱/婴儿保温箱中的婴儿。该传感器将允许监测新生儿的体温,而不存在附接到新生儿的娇嫩皮肤的基于粘合剂的有线传感器的当前问题。
英文摘要
DESCRIPTION (provided by applicant): Summary Neonatal survival is greatly improved by keeping the baby in a controlled temperature environment provided by an incubator/warmer. In order to control body temperature accurately, consistent and reliable temperature measurement of the baby is necessary. This is currently accomplished using a temperature sensor (thermistor) that is affixed to the body by means of an adhesive. This approach has the disadvantage of being a single point measurement and the adhesive can distress the delicate skin of the infant. Furthermore, the sensor is prone to dislodgement, leading to problems with feedback temperature control. For these reasons, we propose to develop and test a non-contact temperature sensing scheme based on a gel that has a temperature sensitive molecule in it. The proposed molecules are fluorescent and their luminescence varies as a function of temperature. With this approach, the gel can be distally excited using an LED and imaged via an inexpensive digital camera. The Center for Advanced Sensor Technology and General Electric Healthcare propose an R21 project that will develop and test the sensing gel and instrumentation for non- contact temperature sensing. The system will be tested on water filled dolls wrapped in pigskin to mimic a neonate. We expect the system to be ready for animal and human trials at the end of the two year project. PUBLIC HEALTH RELEVANCE: A non-contact temperature sensor is proposed for use with infants in incubators/ baby warmers. This sensor will allow for monitoring body temperature of neonates without the current problems of adhesive-based wired sensors that are attached to the delicate skin of the newborn.
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Non-contact Optical Temperature Sensor for Neonatal Monitoring.
FLUORESCENCE SENSING USING GFP AND SPCE
RATIOMETRIC FLUORESCENCE SENSING OF O2
RATIOMETRIC FLUORESCENCE SENSING OF O2
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