Pittsburgh Center for Pain Research Recruitment of a New Faculty Member

描述(申请人提供)：疼痛是求医的主要原因。AIM并不局限于单一的疾病或医学学科。相反，痛苦是分布在整个生命周期中的，所有人都会经历，无论其地位如何(经济、教育等)。或性别，并产生于身体的所有组织。虽然急性发作的疼痛通常会消失，但许多组织侮辱会导致慢性疼痛状态，而且一些疼痛综合征与明显的病理学无关。导致组织过敏和慢性疼痛的机制，对生活质量、工作场所生产力、人际关系等造成巨大损失的负面影响，目前还知之甚少。对这些机制的研究是匹兹堡疼痛研究中心(Center)的主要研究重点。该中心的核心教师包括那些专注于支配浅表和深层组织(如肌肉和内脏)的伤害性感受器的转导和信号传递，延髓和脊髓背角伤害性输入的回路和调制，疼痛特征个体差异的遗传机制，以及成人神经系统感觉神经元发育、分化和功能的机制。作为这项申请的基础的项目计划的目的是通过RFA招聘一名新的初级教员进入中心，从而扩大中心研究专业知识和研究项目的广度和深度。核心教员已经确定了对该中心的发展至关重要的两个广泛的研究领域：翻译研究，特别是流行病学、临床心理学、脑成像或显微神经学。免疫学或分子生物学我们已经确定了招聘领域，这些领域将使中心拥有更好的研究和培训环境，并且由于我们致力于卓越的研究和合作，也将促进招募人员的研究计划和职业发展。

DESCRIPTION (provided by applicant): Pain is the principal reason for seeking medical attention. Aim is not restricted to a single disease or medical discipline. Pain is, instead, distributed across the span of life, is experienced by all persons irrespective of status (economic, educational, etc.) or gender and arises from all tissues of the body. While acute episodes of pain typically resolve, many tissue insults lead to chronic pain states, and some pain syndromes are not associated with demonstrable pathology. The mechanisms that lead to tissue hypersensitivity and chronic pain, which negatively impacts quality of life, workplace productivity, interpersonal relationships, etc. at enormous cost, are poorly understood. Study of these mechanisms is the principal focus of research in the Pittsburgh Center for Pain Research (Center). Core faculty in the Center include those with a focus on transduction and signaling in nociceptors innervating superficial as well as deep tissues (e.g., muscle and viscera), circuitry and modulation of nociceptive input in the medullary and spinal dorsal horn, genetic mechanisms of individual variability in pain traits, and mechanisms that underlie sensory neuron development, differentiation and function in the adult nervous system. The Aim of the PROGRAM PLAN that is the basis of this application is to expand the breadth and depth of research expertise and research programs in the Center by recruitment through this RFA of a new junior faculty member into the Center. Core faculty has identified two broad areas of research important for growth of the Center: Translational Research, specifically epidemiology, clinical psychology, brain imaging or microneurography. Immunology or Molecular Biology We have identified areas for recruitment that will make the Center a better research and training environment and, because of our commitment to research excellence and collegiality; will enhance the research program and career development of the recruit as well.