NEW FACULTY RECRUITMENT IMAGE-GUIDED CANCER THERAPEUTICS

新教师招聘 影像引导癌症治疗

• 批准号: 7856254
• 负责人: JEFFREY L. DUERK
• 金额: $ 36.58万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7856254
• 关键词: Antineoplastic Agents; Atherosclerosis; Basic Science; Biological Markers; Biomedical Engineering; Characteristics; Clinical; Comprehensive Cancer Center; Computer Simulation; Development; Diagnosis; Disease; Drug Delivery Systems; Engineering; Evaluation; Faculty; Goals; Healthcare; Image; Imaging Device; Imaging technology; In Vitro; Industry; Ischemia; Knowledge; Lead; Malignant Neoplasms; Medical; Medical Imaging; Methods; Mission; Monitor; Nanotechnology; Occupations; Ohio; Oncologist; Outcome; Patients; Permeability; Recruitment Activity; Research; Technology; Therapeutic; Translational Research; Translations; Treatment Protocols; Universities; Vascular Permeabilities; Vision; angiogenesis; base; cancer imaging; cancer therapy; clinically relevant; density; design; dosage; economic impact; image guided therapy; imaging probe; improved; in vivo; medical schools; member; molecular imaging; nanoparticle; nanoscale; novel; novel strategies; professor; prognostic; programs; public health relevance; tool; tumor; tumor growth

DESCRIPTION (provided by applicant): The Department of Biomedical Engineering (BME) at Case Western Reserve University (CWRU) views translational research, nanotechnology, and development of biomedical and radiologic imaging as part of its vision and mission. Via the recruitment of a tenure-track Assistant Professor, we seek to investigate "Image-Guided Cancer Therapeutics" by exploiting the nanoscale control in fabricating nanoparticles to design multifunctional agents that facilitate diagnosing, treating and monitoring of cancer therapies. Today's cancer therapeutics take a 'one-size-fits-all' approach to dosage and delivery of drugs, and new improved therapeutic strategies have to be explored that incorporate the technological pieces of a puzzle that can lead to customized, patient-specific therapeutic strategies. Specifically, we propose to recruit a tenure track faculty member to help unite the full spectrum of engineering, imaging and cancer expertise at CWRU. Such a program will exploit the existing strengths of the drug delivery, nanotechnology and imaging components of the BME Department, Case Center for Imaging Research, and the superb medical and basic research occurring at the School of Medicine, and the Case Comprehensive Cancer Center to develop an extremely collaborative program aimed at clinical translation and development of novel imaging tools as enablers of improved therapies in a patient-specific manner via non-invasive interrogation of tumor vasculature status. To achieve these goals, the program will utilize engineering approaches including in silico, in vitro and in vivo studies. Importantly, these tools can serve as platform technologies for other diseases where knowledge of vasculature status and integrity is of great importance (e.g. atherosclerosis, ischemia). The goal of the proposed program is to develop translational and clinically-relevant imaging technologies that non-invasively can detect and monitor (1) cancer status and (2) predict and monitor the effects of anticancer drugs in a patient-specific manner. This program will further contribute to the fast growing nanotech, cancer therapy and imaging, and medical industries of Ohio. Besides the significant impact on healthcare, this program can potentially facilitate job creation and long-term economic impacts for Ohio. PUBLIC HEALTH RELEVANCE (provided by applicant): Today's cancer therapeutics take a 'one-size-fits-all' approach, and new improved, customizable therapies have to be explored. Via the recruitment of an Assistant Professor, this program aims to integrate nanotechnology with clinically-relevant imaging to provide prognostic and monitoring tools of treatments in a patient-specific manner that enables oncologists to better differentially select therapeutic regimens.

描述（由申请人提供）：Case Western Reserve University（CWRU）的生物医学工程系（BME）认为转化研究，纳米技术以及生物医学和放射学成像的开发是其愿景和使命的一部分。通过招募终身训练助理教授，我们试图通过利用纳米级控制来制造纳米颗粒来设计多功能药物来研究“图像引导的癌症治疗剂”，以促进促进癌症治疗的诊断，治疗和监测。当今的癌症治疗药对药物的剂量和递送采用了“一定大小的全能”方法，必须探索新的改进的治疗策略，以结合一种可以导致定制的，特定于患者的治疗策略的拼图的技术。具体来说，我们建议招募一名终身轨道教师，以帮助CWRU团结整个工程，成像和癌症专业知识。这样的计划将利用BME部门的药物输送，纳米技术和成像组成部分的现有优势，案例中心的成像研究中心以及医学院发生的精湛的医学和基础研究以及案例综合癌症中心，以开发出极为协作的计划，旨在通过临床翻译和开发不合时宜的工具来启用不合时宜的工具，以实现临床的转换和开发，以实现不合时宜的工具。脉管状态。 为了实现这些目标，该计划将利用包括硅，体外和体内研究在内的工程方法。重要的是，这些工具可以用作其他疾病的平台技术，在这些疾病中，对脉管系统的知识和完整性知识非常重要（例如，动脉粥样硬化，缺血）。该计划的目标是开发不可侵袭性可以检测和监测（1）癌症状态的转化和临床成像技术，以及（2）以患者特异性方式预测和监测抗癌药物的影响。该计划将进一步促进俄亥俄州快速增长的纳米技术，癌症疗法和成像以及医疗行业。除了对医疗保健的重大影响外，该计划还可以促进创造就业机会和对俄亥俄州的长期经济影响。 公共卫生相关性（由申请人提供）：当今的癌症治疗学采用“一定程度的全部”方法，并且必须探索新的改进，可定制的疗法。通过招聘助理教授，该计划旨在将纳米技术与临床上相关的成像整合起来，以特定于患者的方式提供预后和监测治疗工具，使肿瘤学家能够更好地选择差异化治疗方案。