Parallel Excitation Methods for High Field MRI
Parallel Excitation Methods for High Field MRI
批准号:
7858408
负责人:
Lawrence L Wald
金额:
$38.09万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-09-15 至 2011-09-14
关键词:
3-DimensionalAccelerationAddressAdolescentAnatomyBiologicalBiomedical EngineeringBrainBrain imagingClinicalComplexComputer softwareDataDependenceDetectionDevelopmentDiagnosticDimensionsDiseaseElectromagneticsElementsEngineeringEnsureEquationEvolutionFamily suidaeFiber OpticsGoalsHeadHealthHot SpotHumanImageImaging PhantomsIndividualLeadLengthLiteratureLobeLocationMagnetic Resonance ImagingMapsMeasurementMeasuresMethodologyMethodsModelingMonitorMorphologic artifactsPatternPhasePhysiologic pulsePositioning AttributeProceduresProcessProgram DevelopmentPropertyProtonsRelative (related person)ResolutionSafetySamplingScalp structureSchemeSepharoseSeriesSeveritiesShapesSimulateSliceSourceStructureSystemTechnologyTemperatureTestingThermometersTimeTissuesValidationVariantWeightWorkdensitydesignflyhuman subjectimprovedinfancymedical specialtiesresponsesimulationsystems researchtransmission process
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Higher field (7T) MRI offers many potential advantages to clinical and scientific studies, including increased sensitivity and in many cases improved contrast. Demonstration of this potential in specialized studies has resulted in the proliferation of 7T and even 9.4T human scanners. There are, however, outstanding methodological challenges to bringing these systems from the research to the clinical arena. One of the most limiting issues is the ability to achieve uniform image contrast over the body. The source of this confound is the shortened RF wavelength in biological tissues leading to spatial inhomogeneities of the transmit B1 field, which, in turn lead to contrast variations in many sequences. In a conventional T1 weighted volume acquisition, the image contrast can change over an order of magnitude over the head at 7T. RF excitation in the presence of time-varying gradients offers the potential of multi-dimensional selective excitation. In this scheme, the excitation is shaped to mitigate the B1 pattern measured in the head. The principal challenge is to encode the 3D excitation in a short enough time to be useful for a wide variety of sequences, including 2D slice selective sequences as well as 3D (non-selective) acquisitions. We propose a development program to test the ability the spatially shaped pulses to mitigate B1 inhomogeniety in the head at 7T. Our first aim is to develop the RF transmit arrays needed to decrease the length of time spent encoding these pulses using the transmit SENSE method. Our second aim is to improve the methods used for calculating the accelerated pulses and test the limits of the transmit SENSE approach in the head at 7T, including high flip angle excitations. Our third aim is to build the methodology that will be needed to safely and accurately monitor local SAR levels for transmit arrays and assess the SAR penalty associated with constructive interference from the E fields of the multiple transmit channels.
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Technology for MR brain monitoring
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批准号:10861524
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项目类别:
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资助金额:$60.2万
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财政年份:2023
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负责人:Lawrence L Wald
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依托单位:
Addressing biological barriers in in vivo human brain MRI acquisitions
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批准号:10224852
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项目类别:
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资助金额:$25.68万
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财政年份:2020
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负责人:Lawrence L Wald
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依托单位:
Addressing biological barriers in in vivo human brain MRI acquisitions
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批准号:10038181
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项目类别:
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资助金额:$26.21万
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财政年份:2020
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负责人:Lawrence L Wald
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依托单位:
A magnetic particle imager (MPI) for functional brain imaging in humans
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批准号:10377310
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项目类别:
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资助金额:$127.56万
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财政年份:2017
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负责人:Lawrence L Wald
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依托单位:
A magnetic particle imager (MPI) for functional brain imaging in humans
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批准号:9991850
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项目类别:
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资助金额:$128.58万
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财政年份:2017
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负责人:Lawrence L Wald
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依托单位:
A magnetic particle imager (MPI) for functional brain imaging in humans
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批准号:9418281
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项目类别:
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资助金额:$101.01万
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财政年份:2017
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负责人:Lawrence L Wald
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依托单位:
A magnetic particle imager (MPI) for functional brain imaging in humans
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批准号:9756374
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项目类别:
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资助金额:$140.92万
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财政年份:2017
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负责人:Lawrence L Wald
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依托单位:
System Upgrade for Siemens 7T Human MRI System
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批准号:9274680
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项目类别:
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资助金额:$200.0万
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财政年份:2017
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负责人:Lawrence L Wald
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依托单位:
Technology for Portable MRI
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批准号:8767453
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项目类别:
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资助金额:$59.89万
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财政年份:2014
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负责人:Lawrence L Wald
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依托单位:
Technology for Portable MRI
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批准号:9132788
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项目类别:
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资助金额:$59.23万
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财政年份:2014
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负责人:Lawrence L Wald
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依托单位:
Technology for Portable MRI
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批准号:9346073
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项目类别:
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资助金额:$60.82万
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财政年份:2014
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负责人:Lawrence L Wald
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依托单位:
Combined shim-RF for improved high field MRI
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批准号:8569251
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项目类别:
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资助金额:$26.1万
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财政年份:2013
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负责人:Lawrence L Wald
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依托单位:
Combined shim-RF for improved high field MRI
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批准号:8703103
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项目类别:
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资助金额:$21.1万
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财政年份:2013
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负责人:Lawrence L Wald
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依托单位:
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:8362810
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项目类别:
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资助金额:$37.98万
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财政年份:2011
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负责人:Lawrence L Wald
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依托单位:
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:8171482
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项目类别:
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资助金额:$30.26万
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财政年份:2010
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负责人:Lawrence L Wald
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依托单位:
7 TESLA TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:7957658
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项目类别:
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资助金额:$6.54万
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财政年份:2009
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负责人:Lawrence L Wald
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依托单位:
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:7957662
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项目类别:
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资助金额:$34.35万
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财政年份:2009
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负责人:Lawrence L Wald
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依托单位:
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:7723785
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项目类别:
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资助金额:$24.79万
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财政年份:2008
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负责人:Lawrence L Wald
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依托单位:
7 TESLA TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:7723781
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项目类别:
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资助金额:$4.72万
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财政年份:2008
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负责人:Lawrence L Wald
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依托单位:
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGING
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批准号:7602564
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项目类别:
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资助金额:$24.71万
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财政年份:2007
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负责人:Lawrence L Wald
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依托单位:
海外基金