4th Meeting of the International Consortium of Bladder Cancer (ICBC)

国际膀胱癌联盟（ICBC）第四次会议

• 批准号: 8006232
• 负责人: Xifeng Wu
• 金额: $ 1万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006232
• 关键词: Area; Basic Science; Biological; Cancer Center; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communities; Data; Data Collection; Development; Epidemiology; Evaluation Studies; Face; Genes; Genetic; Genetic Models; Genetic Predisposition to Disease; International; Malignant neoplasm of urinary bladder; Maps; Meta-Analysis; Methods; Mind; Modeling; Outcome; Outcome Study; Participant; Population; Preventive screening; Process; Public Health; Publishing; Questionnaires; Reporting; Request for Applications; Research; Research Personnel; Resources; Risk; Sample Size; Sampling; Scanning; Science; Therapeutic Intervention; Translating; Translations; University of Texas M D Anderson Cancer Center; Validation; anticancer research; cancer diagnosis; case control; cost; data sharing; functional genomics; gene environment interaction; genetic epidemiology; genetic risk factor; genome wide association study; improved; meetings; men; programs; public health relevance; response

DESCRIPTION (provided by applicant): This application requests support to offset the costs associated with a consortium meeting entitled, "The Fourth Meeting of the International Consortium of Bladder Cancer", sponsored partially by the University of Texas M. D. Anderson Cancer Center, Nov 29th-30th, 2010, at the M. D. Anderson Cancer Center. The International Consortium of Bladder Cancer consists of 22 independent studies world-wide with over 9,800 cases and similar number of controls led by the top investigators in bladder cancer research encompassing the fields of clinical research, epidemiology, genetics, and basic science. With the rapid progress on genome-wide association study (GWAS), we have great challenges and opportunities lying ahead, for example, in the area of functional genomics, gene-gene and gene-environment interaction, comprehensive risk prediction model incorporating environmental and genetic risk factors, genetic predictors of clinical outcomes. The proposed meeting will be important and timely to the bladder cancer research community that will prompt leading bladder cancer researchers to face these challenges of post-GWAS era collectively. There are increasing needs for large sample sizes, standardized methods of sample processing, questionnaire development, data collection and analysis, mechanisms to rapidly replicate previously reported associations and pooling of comparable data on environmental and genetic risk factors across different studies, and comparable clinical data and endpoints for outcome study. With these challenges and basic needs in mind, we propose the following objectives for the meeting: 1) to promote collaborations to accelerate transdisciplinary research to move the findings from GWAS through pooled analyses of scan data, replication studies, evaluation of gene-environment interactions and pathway analyses, and biological validation through fine mapping and functional studies. This research should result in improvements of risk models and public health translation into preventive and screening programs; 2) to promote collaborations to accelerate transdisciplinary research on GWAS for clinical outcomes and response to therapy, and translate these findings into improved therapeutic interventions; 3) to coordinate the recruitment and collection of well-characterized populations of cases and controls using standardized methods of collection, storage, processing, and data collection, which will include detailed information on epidemiologic profiles, exposure and clinical outcome; 4) to facilitate the pooling of data and sharing of biospecimen and data resources from independent studies; 5) to provide a forum for the interchange of ideas and expertise to initiate new collaborative studies; 6) to publish the proceedings as a resource for participants and other bladder cancer investigators. PUBLIC HEALTH RELEVANCE: Bladder cancer is the fourth most frequent cancer diagnosed in men and recent genome-wide association study (GWAS) has convincingly identified at least 3 genetic susceptibility loci for bladder cancer. Great challenges and opportunities lie ahead in the area of functional genomics, gene-gene and gene-environment interaction, comprehensive risk prediction model, and genetic predictors of clinical outcomes. The International Consortium of Bladder Cancer provides a unique platform to facilitate collaboration and advance science, and the proposed 4th meeting will be important and timely to the bladder cancer research community that will prompt leading bladder cancer researchers to face the challenges of post-GWAS era collectively.

描述(由申请人提供)：本申请请求资助，以抵消与2010年11月29日至30日在安德森癌症中心举行的名为“国际膀胱癌联合会第四次会议”的财团会议相关的费用，该会议由德克萨斯大学安德森癌症中心赞助。国际膀胱癌联合会由全球22项独立研究组成，超过9800例病例和类似数量的对照研究由膀胱癌研究领域的顶级研究人员领导，涵盖临床研究、流行病学、遗传学和基础科学等领域。随着全基因组关联研究的快速发展，在功能基因组学、基因-基因和基因-环境相互作用、结合环境和遗传危险因素的综合风险预测模型、临床预后的遗传预测因子等方面，我们面临着巨大的挑战和机遇。拟议中的会议对膀胱癌研究界来说将是重要的和及时的，它将促使主要的膀胱癌研究人员共同面对后GWA时代的这些挑战。越来越需要大样本量、标准化的样本处理方法、问卷开发、数据收集和分析、快速复制以前报告的相关性的机制和汇集不同研究中关于环境和遗传风险因素的可比数据，以及用于结果研究的可比临床数据和终点。考虑到这些挑战和基本需求，我们为这次会议提出了以下目标：1)促进合作，以加快跨学科研究，通过扫描数据的汇集分析、重复研究、基因-环境相互作用和途径分析的评估，以及通过精细绘图和功能研究的生物学验证，将研究结果从GWAS中转移出来。这项研究应改进风险模型，并将公共卫生转化为预防和筛查计划；2)促进合作，以加快对临床结果和治疗反应的跨学科研究，并将这些发现转化为改进的治疗干预措施；3)利用标准化的收集、存储、处理和数据收集方法，协调招募和收集具有良好特征的病例和对照人群，其中将包括流行病学概况、暴露和临床结果的详细信息；4)促进数据汇集和共享来自独立研究的生物光谱和数据资源；5)为交流想法和专业知识提供一个论坛，以启动新的合作研究；6)出版会议记录，作为参与者和其他膀胱癌研究人员的资源。 公共卫生相关性：膀胱癌是男性中第四常见的癌症，最近的全基因组关联研究(GWAS)令人信服地确定了至少3个膀胱癌的遗传易感基因。在功能基因组学、基因-基因和基因-环境相互作用、全面的风险预测模型和临床结果的遗传预测因子等领域，面临着巨大的挑战和机遇。国际膀胱癌联合会为促进合作和推动科学进步提供了一个独特的平台，拟议中的第四次会议对膀胱癌研究界来说将是重要和及时的，它将促使领先的膀胱癌研究人员集体面对后GWAS时代的挑战。