11th International Conference on Developmental Nephrology

描述（由申请人提供）：项目概述国际发育肾病学研讨会于1980年启动，作为研究人员交流思想和批判性评价最近工作的小型会议论坛，重点是肾胚胎发生、出生后功能发育和肾代谢。该研讨会取得了巨大的成功，并促使组织了随后的三年一次的会议，这些会议已被广泛认为是最重要的小型肾脏病学会议之一。第11届国际发育肾脏学研讨会题为“遗传程序设计和肾脏：健康和疾病中的祖细胞、信号传导和形态发生”代表了儿科肾病学家、发育生物学家、发育生理学家、细胞生物学家和遗传学家的第11次国际聚会，讨论新的科学进展，并参与有关生物学、病理生理学、以及发育中的肾脏和泌尿道的遗传学。目前的R13申请寻求资金，以支持高级博士后和研究员以及年轻研究人员的旅行奖励。虽然来自基金会，企业赞助商和国际儿科肾病协会（IPNA）的资金将支付基本的会议费用，但所要求的R13资金将作为我们的唯一资金来源，为高级学员和初级研究人员提供多达10笔差旅赠款。我们相信，第11届国际发育肾病研讨会的会议形式和杰出的发言者名单将为合格的初级教师和高级博士后提供独特的教育机会。他们不仅将接触到尖端科学，而且研讨会的场地非常有利于小组讨论和互动，这将激发参与者之间新的协作互动。会议将于2010年8月24日至27日在纽约新帕尔茨举行，紧接着将在纽约市举行的第14届IPNA大会。 公共卫生相关性：在过去的50年里，发育肾生理学已经发展成为一个研究领域，同时儿科肾病学也发展成为一个临床学科。到1980年，这一领域的研究人员数量达到了临界质量，促使在纽约组织了第一届国际肾脏发育生理学研讨会。这一首次研讨会的成功导致了随后每隔3年组织一次研讨会，每次研讨会都与国际儿科肾病协会（IPNA）三年一次的大会相结合。这些研讨会最初旨在提供一个全面的计划，突出发展肾脏学的最新进展。然而，最近细胞和分子生物学的爆炸，以及肾脏疾病的分子遗传学，吸引了来自许多学科的研究人员将注意力集中在发育中的肾脏上。第11届国际发育肾脏学研讨会题为“遗传编程和肾脏：健康和疾病中的祖细胞，信号传导和形态发生”，已组织接受来自广泛学科的研究人员，包括儿科肾脏学，肾脏医学，生理学，细胞生物学，发育生物学，病理学，分子生物学和遗传学。在为期两天半的会议中，三个最先进的演讲将集中在以下主题：1）祖细胞群的调节，2）发育器官中的活细胞成像，3）影响细胞分化的小分子筛选。六个专题讨论会的主题包括：1）干细胞，祖细胞和再生; 2）后肾领域的分子机制和模式; 3）肾集合系统的形态发生; 4）肾单位形成的信号和控制; 5）下尿路的模式和形态发生;和6）分子信号和上皮分化。每次会议将包括更多的知名调查员和年轻的调查员。此外，将鼓励与会者提交摘要，供在两次海报讨论会上介绍。我们相信，第11届国际发育肾病研讨会的会议形式和杰出的发言者名单将为合格的初级教师和高级博士后提供特别重要的教育机会。他们不仅将接触到尖端科学，而且研讨会的场地非常有利于小组讨论和互动，这将激发参与者之间新的协作互动。这个R13应用程序的目标是为最多10名年轻科学家参加这个充满活力的会议提供部分旅行和住宿支持。

DESCRIPTION (provided by applicant): PROJECT SUMMARY The International Developmental Nephrology Workshop was initiated in 1980 as a small meeting forum for investigators to exchange ideas and critically evaluate recent work focused on renal embryogenesis, postnatal functional development, and renal metabolism. The Workshop was an unqualified success and spurred the organization of subsequent triennual meetings that have become widely recognized as one of the premier small nephrology meetings. The 11th International Developmental Nephrology Workshop entitled "Genetic Programming and the Kidney: Progenitors, Signaling and Morphogenesis in Health and Disease" represents the 11th international gathering of pediatric nephrologists, developmental biologists, developmental physiologists, cell biologists, and geneticists to discuss new scientific advances and engage in dynamic exchanges of ideas and concepts relating to the biology, pathophysiology, and genetics of the developing kidney and urinary tract. The current R13 application seeks funding to support travel awards for senior post-docs and fellows, as well as young investigators. While funding from foundations, corporate sponsors, and the International Pediatric Nephrology Association (IPNA) will cover the basic meeting expenses, the requested R13 funds will serve as our sole funding source for awarding up to 10 travel grants for senior trainees and junior investigators. We believe that the meeting format and the outstanding slate of speakers assembled for the 11th International Developmental Nephrology Workshop will provide a unique educational opportunity for qualified junior faculty and senior post-docs. Not only will they be exposed to cutting edge science, but the Workshop venue is highly conducive to small group discussions and interactions that should spark new collaborative interactions among the participants. The meeting will be held in New Paltz, New York from August 24-27, 2010, immediately preceding the 14th IPNA Congress to be held in New York City. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Over the past 50 years, developmental renal physiology has evolved as an investigative field concurrent with the development of pediatric nephrology as a clinical discipline. By 1980, the number of investigators in this field had reached a critical mass, prompting the 1st International Workshop on Developmental Renal Physiology to be organized in New York. The success of this initial Workshop led to the organization of subsequent Workshops at 3-year intervals, each in conjunction with the triennial Congress of the International Pediatric Nephrology Association (IPNA). These Workshops initially aimed to provide a comprehensive program that highlighted recent advances in developmental nephrology. However, the recent explosion in cellular and molecular biology, as well as the molecular genetics of renal disease, has enticed investigators from many disciplines to focus their attention on the developing kidney. The 11th International Developmental Nephrology Workshop entitled "Genetic Programming and the Kidney: Progenitors, Signaling and Morphogenesis in Health and Disease" has been organized to embrace investigators from a broad range of disciplines, including pediatric nephrology, renal medicine, physiology, cell biology, developmental biology, pathology, molecular biology and genetics. In this two and a half day meeting, three State-of-the-Art presentations will focus on topics ranging from 1) The regulation of progenitor populations, to 2) live cell imaging in developing organs, to 3) screening for small molecules that affect cell differentiation. Six symposia will be presented with topics that include: 1) Stem Cells, Progenitors, and Regeneration; 2) Molecular mechanisms and patterning of the metanephric field; 3) Morphogenesis of the Renal Collecting System; 4) Signaling and Control of Nephron Formation; 5) Patterning and Morphogenesis of the Lower Urinary Tract; and 6) Molecular Signaling and Epithelial Differentiation. Each session will include more well-established investigators and younger investigators. In addition, participants will be encouraged to submit abstracts for presentation in two poster discussion sessions. We believe that the meeting format and the outstanding slate of speakers assembled for the 11th International Developmental Nephrology Workshop will provide a particularly important educational opportunity for qualified junior faculty and senior post-docs. Not only will they be exposed to cutting edge science, but the Workshop venue is highly conducive to small group discussions and interactions that should spark new collaborative interactions among the participants. The goal of this R13 application is to provide partial travel and lodging support for up to 10 young scientists to participate in this dynamic meeting.