Evolution and Development of the Lateral Plate Mesoderm

侧板中胚层的进化和发育

• 批准号: 8007219
• 负责人: Ann Campbell Burke
• 金额: $ 0.57万
• 依托单位: WESLEYAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-10 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007219
• 关键词: Cells; Congenital Abnormality; Congresses; Data; Development; Evolution; Funding; Human; International; Knowledge; Lateral; Locomotor adaptation; Mesoderm; Modeling; Molecular; Morphology; Muscle; Musculoskeletal System; Pattern; Physiological; Play; Population; Prevention; Process; Respiratory Diaphragm; Role; Site; Sternum; Structure; System; Time; Tissue-Specific Gene Expression; Turtles; Uruguay; Variant; Vertebrates; appendage; blastomere structure; cost; innovation; new technology; programs; spine bone structure; symposium

DESCRIPTION (Provided by Applicant): Vertebrate Evolution is characterized by major locomotor adaptations that depend on the developmental potential of the somatic component of the lateral plate mesoderm (LPM). The paired appendages are perhaps the most dramatic of these morphological novelties, but innovations involving the LPM also include the sternum, gastralia, the turtle plastron, epi-pubis, the mammalian diaphragm, and many other muscular specialization of the lateral and ventral body wall of vertebrates. The obvious significance of LPM derived structures to the diversity of vertebrate locomotor and physiological strategies indicates that this embryonic cell population has played a major role in generating adaptive variation. This embryonic cell population, however, has rarely been the specific focus of evolutionary morphologists or developmental biologists. Given new EvoDevo models, growing data from non-model species, and discovery of tissue specific gene expression, it is an excellent time to consolidate data and questions regarding the lateral plate mesoderm. The organizers are seeking funding to offset the costs of registration and accommodations for the invited speakers participating in a symposium entitled "Evolution and Development in the Lateral Plate Mesoderm". This symposium will be part of the program of the Ninth International Congress of Vertebrate Morphology (ICVM 9) that will take place July 26-31 2010 in Punta del Esta, Uruguay. The symposium will bring together paleontologists, developmental, and evolutionary biologists, using both morphological and molecular approaches to discuss major morphological innovations occurring in the lateral plate mesoderm. PROJECT NARRATIVE: The lateral pate mesoderm provides essential cell populations and patterning information for major structures in the vertebrae musculoskeletal system. These structures are the site of major adaptive innovations in vertebrate lineages, as well as devastating birth defects in humans. Most birth defects in the human musculoskeletal system result from miss patterning of embryonic cell populations. The remarkable knowledge we have concerning these processes derives directly from study of nonhuman vertebrates. A clear knowledge of specific developmental systems is essential to successfully applying new technologies to the treatment and eventual prevention of birth defects.

描述（由申请人提供）：脊椎动物进化的特征在于主要的运动适应，其取决于侧板中胚层（LPM）的体细胞组分的发育潜力。 成对的附肢也许是这些形态学上的新奇事物中最引人注目的，但涉及LPM的创新还包括胸骨、腹甲、海龟腹甲、耻骨上、哺乳动物横膈膜以及脊椎动物侧腹体壁的许多其他肌肉特化。 LPM衍生结构对脊椎动物运动和生理策略多样性的明显意义表明，这种胚胎细胞群体在产生适应性变异中发挥了重要作用。 然而，这种胚胎细胞群很少成为进化形态学家或发育生物学家的具体焦点。 鉴于新的EvoDevo模型，非模型物种的数据不断增长，以及组织特异性基因表达的发现，这是一个很好的时间来巩固关于侧板中胚层的数据和问题。 组织者正在寻求资金，以抵消受邀发言者参加题为“侧板中胚层的演变和发展”专题讨论会的登记和住宿费用。 本次研讨会将是第九届国际脊椎动物形态学大会（ICVM 9）的一部分，将于2010年7月26日至31日在乌拉圭的蓬塔德尔埃斯塔举行。 研讨会将汇集古生物学家，发育和进化生物学家，使用形态和分子方法来讨论侧板中胚层发生的主要形态创新。 项目叙述：侧颈部中胚层为椎骨肌肉骨骼系统的主要结构提供了必要的细胞群和图案信息。 这些结构是脊椎动物谱系中主要适应性创新的场所，也是人类毁灭性出生缺陷的场所。 人类肌肉骨骼系统中的大多数出生缺陷都是由于胚胎细胞群体的错误模式造成的。 我们关于这些过程的非凡知识直接来自对非人类脊椎动物的研究。 对特定发育系统的清晰了解对于成功应用新技术治疗和最终预防出生缺陷至关重要。