Evolution and Development of the Lateral Plate Mesoderm

描述(申请人提供)：脊椎动物进化的特征是主要的运动适应，这取决于侧板中胚层(LPM)的躯体成分的发育潜力。成对的附属物可能是这些形态上的新奇事物中最引人注目的，但涉及LPM的创新还包括胸骨、胃、海龟平台、耻骨上、哺乳动物的横隔膜，以及脊椎动物身体侧壁和腹壁的许多其他肌肉特化。LPM衍生结构对脊椎动物运动和生理策略的多样性具有明显的意义，表明该胚胎细胞群在产生适应性变异中发挥了重要作用。然而，这种胚胎细胞群体很少成为进化形态学家或发育生物学家特别关注的焦点。鉴于新的EvoDevo模型、来自非模式物种的不断增长的数据以及组织特异性基因表达的发现，现在是整合关于侧板中胚层的数据和问题的绝佳时机。主办方正在寻求资金，以补偿参加题为“侧板中胚层的演化和发展”的研讨会的受邀演讲者的注册和住宿费用。本次研讨会将是将于2010年7月26-31日在乌拉圭埃斯特角举行的第九届国际脊椎动物形态学大会(ICVM9)的一部分。研讨会将汇集古生物学家、发育生物学家和进化生物学家，使用形态和分子方法讨论发生在侧板中胚层的主要形态创新。 项目简介：侧头中胚层为椎骨肌肉骨骼系统中的主要结构提供基本的细胞群体和图案信息。这些结构是脊椎动物谱系中重大适应性创新的场所，也是人类毁灭性出生缺陷的场所。人类肌肉骨骼系统中的大多数出生缺陷是由于胚胎细胞群体的错配造成的。我们对这些过程所拥有的非凡知识直接来自于对非人类脊椎动物的研究。对特定发育系统的清楚了解对于成功地将新技术应用于治疗和最终预防出生缺陷至关重要。

DESCRIPTION (Provided by Applicant): Vertebrate Evolution is characterized by major locomotor adaptations that depend on the developmental potential of the somatic component of the lateral plate mesoderm (LPM). The paired appendages are perhaps the most dramatic of these morphological novelties, but innovations involving the LPM also include the sternum, gastralia, the turtle plastron, epi-pubis, the mammalian diaphragm, and many other muscular specialization of the lateral and ventral body wall of vertebrates. The obvious significance of LPM derived structures to the diversity of vertebrate locomotor and physiological strategies indicates that this embryonic cell population has played a major role in generating adaptive variation. This embryonic cell population, however, has rarely been the specific focus of evolutionary morphologists or developmental biologists. Given new EvoDevo models, growing data from non-model species, and discovery of tissue specific gene expression, it is an excellent time to consolidate data and questions regarding the lateral plate mesoderm. The organizers are seeking funding to offset the costs of registration and accommodations for the invited speakers participating in a symposium entitled "Evolution and Development in the Lateral Plate Mesoderm". This symposium will be part of the program of the Ninth International Congress of Vertebrate Morphology (ICVM 9) that will take place July 26-31 2010 in Punta del Esta, Uruguay. The symposium will bring together paleontologists, developmental, and evolutionary biologists, using both morphological and molecular approaches to discuss major morphological innovations occurring in the lateral plate mesoderm. PROJECT NARRATIVE: The lateral pate mesoderm provides essential cell populations and patterning information for major structures in the vertebrae musculoskeletal system. These structures are the site of major adaptive innovations in vertebrate lineages, as well as devastating birth defects in humans. Most birth defects in the human musculoskeletal system result from miss patterning of embryonic cell populations. The remarkable knowledge we have concerning these processes derives directly from study of nonhuman vertebrates. A clear knowledge of specific developmental systems is essential to successfully applying new technologies to the treatment and eventual prevention of birth defects.